A5005402511- Treatment of Major Depression
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Child and Adolescent Psychosocial and Emotional Development
- Mental Health Research Topics
- Attention Deficit Hyperactivity Disorder
- Cardiac Health and Mental Health
- Schizophrenia research and treatment
- Posttraumatic Stress Disorder Research
- Electroconvulsive Therapy Studies
- Obsessive-Compulsive Spectrum Disorders
- Mental Health Treatment and Access
- Bipolar Disorder and Treatment
- Stress Responses and Cortisol
- Maternal Mental Health During Pregnancy and Postpartum
- Perfectionism, Procrastination, Anxiety Studies
- Blood Pressure and Hypertension Studies
- Child and Adolescent Health
- Retinal Development and Disorders
- Eating Disorders and Behaviors
- Functional Brain Connectivity Studies
- Pulmonary Hypertension Research and Treatments
- Pain Management and Placebo Effect
- Anesthesia and Neurotoxicity Research
- Menstrual Health and Disorders
- Big Data and Business Intelligence
NewGen Therapeutics (United States)
2023
Solidus Biosciences (United States)
2021
University Medical Centre Mannheim
2019
Heidelberg University
2019
University Hospital Heidelberg
2019
Pfizer (United States)
1999-2005
Columbia University
2003
Duke University Hospital
2002
Duke Medical Center
2002
University of Connecticut
2001
OBJECTIVE: Previous reports demonstrating quality-of-life impairment in anxiety and affective disorders have relied upon epidemiological samples or relatively small clinical studies. Administration of the same scale, Quality Life Enjoyment Satisfaction Questionnaire, to subjects entering multiple large-scale trials for depression allowed us compare impact these on quality life. METHOD: Baseline demographic, data from 11 treatment trials, including studies major depressive disorder,...
Article AbstractBackground: The demand for effective behavior therapy obsessive-compulsive disorder (OCD) by exposure and ritual prevention exceeds its supply trained therapists. A computer-guided self-help system (BT STEPS) was created that patients access telephone from home via interactive voice response technology. This study compared the value of with clinician-guided systematic relaxation as a control treatment. Method: After screening clinician, 218 DSM-IV OCD at 8 North American...
OBJECTIVE: This study was designed to evaluate the comparative efficacy and safety of sertraline nortriptyline for treatment major depressive disorder in older adults. METHOD: A double-blind, parallel group design used compare 210 outpatients, 60 years age older, who met DSM-III-R criteria episode had a minimum Hamilton Depression Rating Scale score 18. The patients were randomly assigned 12 weeks with either (50–150 mg/day) or (25–100 mg/day). RESULTS: profiles two treatments similar except...
Article AbstractBackground: There has been a paucity ofwell-designed studies comparing selective serotonin reuptakeinhibitor (SSRI) medications in the treatment of depression inthe elderly. This multicenter study was designed to examine theefficacy and safety sertraline fluoxetine depressedelderly outpatients. A secondary objective theeffects SSRI on quality life cognitivefunction. Method: Two hundred thirty-six outpatients 60years age older who met DSM-III-R criteria for majordepressive...
There have been few placebo-controlled trials of selective serotonin reuptake inhibitors for depressed elderly patients. This study sertraline was designed to confirm the results non-placebo-controlled trials.The subjects were outpatients age 60 years or older who had a DSM-IV diagnosis major depressive disorder and total score on 17-item Hamilton Depression Rating Scale 18 higher. The patients randomly assigned 8 weeks double-blind treatment with placebo flexible daily dose 50 100 mg...
Sertraline's efficacy and tolerability in treating generalized anxiety disorder were evaluated.Adult outpatients with DSM-IV a total score of 18 or higher on the Hamilton Anxiety Rating Scale eligible. After 1-week single-blind placebo lead-in, patients randomly assigned to 12 weeks double-blind treatment (N=188, mean baseline score=25) flexible doses (50-150 mg/day) sertraline (N=182, score=25). The primary outcome measure was baseline-to-endpoint change scale score. A secondary Clinical...
Objective: This study determined the efficacy and safety of sertraline in treatment patients with panic disorder. Method: The was a randomized, double-blind, parallel-group, flexible-dose comparison placebo outpatients DSM-III-R diagnosis disorder or without agoraphobia. After 2-week single-blind lead-in, 168 entered 10-week double-blind phase which they were randomly assigned to either placebo.Results: Sertraline significantly more effective than decreasing number full limited-symptom...
Nefazodone is a phenylpiperazine antidepressant with 5-HT 2 antagonism and reuptake inhibition. Two hundred eighty-three out-patients diagnosis of DSM–III–R major depression at least one-month duration (65% ill for over 6 months), mean score 24 on the 17-item Hamilton Rating Scale Depression (HRSD), were randomised to treatment nefazodone, imipramine, or placebo. The double-blind period was 8 weeks in duration. Nefazodone's efficacy comparable imipramine's, both drug treatments significantly...
Results are presented of the first double-blind, placebo-controlled trial a novel antidepressant venlafaxine, which preclinically has demonstrated serotonin, norepinephrine, and dopamine reuptake inhibiting effects. Sixty outpatients meeting DSM-III-R criteria for major depression were randomized to receive 6 weeks treatment with one three fixed doses venlafaxine—25 mg times day, 75 or 125 day—or placebo. Significant improvement was observed in scores at all doses, high dose resulting...
<h3>Background</h3> Serotonin reuptake inhibitors (SRIs) have demonstrated consistent efficacy in the treatment of obsessive-compulsive disorder (OCD), while agents that are primarily norepinephrine not. Comparable has been for SRI and non-SRI antidepressants uncomplicated major depressive (MDD). This multicenter trial is first comparison an (sertraline) a antidepressant (desipramine) OCD with concurrent MDD. <h3>Methods</h3> One hundred sixty-six patients diagnosed using structured clinical...
Objectives. To analyze the effects of antidepressants on cognitive functioning in elderly depression. Methods. Data were pooled for participants with major depression from two double-blind 12-week studies (n = 444) comparing sertraline to fluoxetine and nortriptyline. A battery was performed pre-treatment post-treatment that included Shopping List Task (SLT), which quantifies short-term long-term memory storage retrieval, Digit Symbol Substitution Test (DSST), measures visual tracking, motor...
Article Abstract Objective: The goal of the current study was to characterize quality life (QOL) and functional impairment associated with posttraumatic stress disorder (PTSD) report QOL/functional response over course long-term treatment. Method: QOL psychosocial functioning were analyzed in 359 randomly assigned patients across a 3-phase sertraline treatment chronic DSM-III-R-defined PTSD: (1) 12 weeks double-blind, placebo-controlled acute flexible doses 50 200 mg/day, (2) 24 open-label...
Article AbstractBackground: Generalized social anxiety disorder is an early onset, highly chronic, frequently disabling with a lifetime prevalence of approximately 13%. The goal the current study was to evaluate efficacy and tolerability sertraline for treatment severe generalized in adults. Method: After 1-week single-blind placebo lead-in period, patients DSM-IV phobia were randomly assigned 12 weeks double-blind flexible doses (50-200 mg/day) or placebo. Primary outcomes mean change...
Objectives: To report on the efficacy, safety, and tolerability of sertraline in treatment elderly depres‐sed patients with without comorbid medical illness. Setting: Multicenter. Design: Randomized, double‐blind, placebo‐controlled study. Participants: A total 752 aged 60 older diagnosis major depressive disorder according to Diagnostic Statistical Manual Mental Disorders, Fourth Edition , diagnosis. Measurements: Outcome measures included 17‐item Hamilton Depression Scale (HAMD); Clinical...
ABSTRACT A placebo‐controlled, randomized, double‐blind study was carried out in outpatients suffering from major unipolar depressive disorder to assess the efficacy and tolerability of paroxetine treatment depression. The lasted for six weeks. After a placebo washout period 4 14 days patients took 20mg or matched as morning dose one week; thereafter could be titrated between 10 SOmg/day. Patients were evaluated at baseline, weekly during first four weeks study, end sixweeks; who entered...
Background. Sertraline has a proved efficacy in post-traumatic stress disorder (PTSD), but it is unknown which symptoms respond or what sequence this occurs. Such information might be useful clinically and heuristically. Method. The study examined the effects of sertraline on individual PTSD. It also whether early changes anger explained drug-induced change other over time. Mixed models analysis was applied to datasets from two 12-week placebo-controlled trials sertraline. A validated...
Background . Few randomized, double-blind studies that examine antidepressant treatment in patients 70 years and older are available. To provide additional data on the safety efficacy of antidepressants this rapidly growing population segment, a subgroup analysis larger sertraline vs. nortriptyline elderly depression study was performed. Methods Outpatients ( N = 76) who met DSM-III-R criteria for major with minimum Hamilton Depression Rating Scale (HAM-D) severity score 18 were randomized...
The authors used seven definitions of response in panic disorder to compare patient-rated improvements quality life between patients with who responded sertraline and those placebo.They combined examined data from two multicenter, randomized, double-blind, parallel-group, flexible-dose studies (N=302).Significant differences placebo were apparent across all the clinical response.Patients respond treatment may show symptom relief but not experience improvement life. Determinations should be...