A5037157365- Regulation of Appetite and Obesity
- Pancreatic function and diabetes
- Biochemical Analysis and Sensing Techniques
- Sleep and Wakefulness Research
- Erythrocyte Function and Pathophysiology
- Amino Acid Enzymes and Metabolism
- Metabolism, Diabetes, and Cancer
- Cannabis and Cannabinoid Research
- Light effects on plants
- Circadian rhythm and melatonin
- Monetary Policy and Economic Impact
- Colorectal Cancer Treatments and Studies
- Economic Theory and Policy
- Colorectal Cancer Screening and Detection
- Birth, Development, and Health
- Tryptophan and brain disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Economic Growth and Productivity
- Neuroendocrine regulation and behavior
- Polyamine Metabolism and Applications
- Ion Transport and Channel Regulation
- Fibroblast Growth Factor Research
- Diet, Metabolism, and Disease
- Genetic factors in colorectal cancer
- Neuroscience of respiration and sleep
San Sebastián University
2023-2025
University of Concepción
2014-2023
Universidad del Desarrollo del Estado de Puebla
2023
Hypothalamic glucosensing, which involves the detection of glucose concentration changes by brain cells and subsequent release orexigenic or anorexigenic neuropeptides, is a crucial process that regulates feeding behavior. Arcuate nucleus (AN) neurons are classically thought to be responsible for hypothalamic glucosensing through direct sensing mechanism; however, recent data has shown metabolic interaction between tanycytes AN lactate may also contributing this process. Monocarboxylate...
Abstract Glucose is a key modulator of feeding behavior. By acting in peripheral tissues and the central nervous system, it directly controls secretion hormones neuropeptides modulates activity autonomic system. GLUT2 required for several glucoregulatory responses brain, including behavior, localized hypothalamus brainstem, which are main centers that control this In hypothalamus, has been detected glial cells, known as tanycytes, line basal walls third ventricle (3V). This study aimed to...
Previous studies indicate that the activity of hypothalamic POMC neurons can be regulated by glucose via intracellular mechanisms, but its regulation lactate is poorly understood. In addition to energetic role, acts as a signaling molecule. this study, we evaluated function and location receptor, hydroxycarboxylic acid receptor 1 (HCAR1). We used conditional genetic approach label their sensitivity using patch-clamp recordings. L-Lactate 3-chloro-5-hydroxybenzoic (3Cl-HBA), HCAR1 specific...
Abstract Glucokinase (GK), the hexokinase involved in glucosensing pancreatic β-cells, is also expressed arcuate nucleus (AN) neurons and hypothalamic tanycytes, cells that surround basal third ventricle (3V). Several lines of evidence suggest tanycytes may be regulation energy homeostasis. Tanycytes have extended cell processes contact feeding-regulating AN, particularly, agouti-related protein (AgRP), neuropeptide Y (NPY), cocaine- amphetamine-regulated transcript (CART)...
Glucokinase (GK), the hexokinase involved in glucose sensing pancreatic β cells, is also expressed hypothalamic tanycytes, which cover ventricular walls of basal hypothalamus and are implicated an indirect control neuronal activity by glucose. Previously, we demonstrated that GK was preferentially localized tanycyte nuclei euglycemic rats, has been reported hepatocytes suggestive presence regulatory protein, GKRP. In present study, intracellular localization hepatic tissues same rats under...
In the arcuate nucleus of hypothalamus, tanycyte-neuron interactions regulate glucose homeostasis and feeding behavior. Previously, we reported that monocarboxylate transporters (MCT) 1 4 are localized in tanycytes, whereas MCT2 is present neurons, including orexigenic anorexigenic neurons (POMC). MCT1 MCT4 inhibition impacts behavior, suggesting transfer between tanycytes influences food intake. Electrophysiological studies have shown POMC respond to lactate through transport indirect...
In the adult hypothalamus, neuronal precursor role is attributed to radial glia-like cells that line third-ventricle (3V) wall called tanycytes. Under nutritional cues, including hypercaloric diets, tanycytes proliferate and differentiate into mature neurons moderate body weight, suggesting hypothalamic neurogenesis an adaptive mechanism in response metabolic changes. Previous studies have shown tanycyte glucosensing depends on connexin-43 hemichannels (Cx43 HCs), purine release, increased...
Feeding behavior regulation is a complex process, which depends on the central integration of different signals, such as glucose, leptin, and ghrelin. Recent studies have shown that glial cells known tanycytes border basal third ventricle (3V) detect glucose then use glucose-derived signaling to inform energy status arcuate nucleus (ARC) neurons regulate feeding behavior. Monocarboxylate transporters (MCT) 1 MCT4 are localized in cellular processes tanycytes, could facilitate monocarboxylate...
Background Major depression disorder (MDD) and anxiety are common mental disorders that significantly affect the quality of life those who suffer from them, altering person’s normal functioning. From biological perspective, most classical hypothesis explaining their occurrence relies on neurotransmission hippocampal excitability alterations. However, around 30% MDD patients do not respond to medication targeting these processes. Over last decade, involvement inflammatory responses in...
The endocannabinoid system (ECS) is composed of a group Gi-coupled protein receptors and enzymes, producing degrading the endocannabinoids, 2-arachidonoylglycerol (2-AG) N-arachidonoyl-ethanolamine (AEA). Endocannabinoid-mediated signaling modulates brain functions, such as pain, mood, memory feeding behavior. activation ECS associated with overeating obesity; however, expression components this has been only partially studied in hypothalamus, critical region implicated Within region,...
Glucose homeostasis is performed by specialized cells types that detect and respond to changes in systemic glucose concentration. Hepatocytes, β-cells hypothalamic tanycytes are part of the glucosensor cell types, which express several proteins involved sensing mechanism such as GLUT2, Glucokinase (GK) regulatory protein (GKRP). GK catalyzes phosphorylation glucose-6-phosphate (G-6P), its activity subcellular localization regulated GKRP. In liver, when concentration low, GKRP binds holding...
This article examines the deceleration of trend growth in Chile last decade. It is observed that, while between 1990 and 1999, average GDP was around 6.7%, years 2000 2009, this figure dropped to 4.4%. Subsequently, 2010 2019, it fell once again, reaching an 2.9%. Furthermore, projections for 2023-2032 indicate even lower rate 2.1%, marking a cumulative decline over 4.5% two decades. The major drivers slowdown are reduced capital contribution negative Total Factor Productivity (TFP). To...