Background Emergency medical service (EMS) personnel have high COVID-19 risk during resuscitation. The resuscitation protocol for patients with out-of-hospital cardiac arrest (OHCA) was modified in response to the pandemic. However, how adjustments EMS system affected OHCA remains unclear. Methods We analysed data from Taichung registry system. compared outcomes and rescue records 622 cases outbreak period (1 February 30 April 2020) those recorded 570 same 2019. Results two periods did not...

Lung cancer screening using low-dose computed tomography (CT) has been reported to reduce lung cancer-specific mortality for smokers at high risk. However, despite different characteristics of in Asia, there are few data concerning this specific population screening. We aim analyze the performance with CT concurrent chest radiography Taiwan, reference international experience.During 1-year period from January 2012 December 2012, we conducted a retrospective, single-center population-based...

Patients with advanced lung adenocarcinoma harboring epidermal growth factor receptor (EGFR)-activating mutations have good response rate and longer progression-free survival (PFS) when treated the tyrosine kinase inhibitors (TKI) compared platinum-based chemotherapy. However, studies comparing effectiveness of these drugs as first-line therapy in such patients are limited.We analyzed 422 EGFR-mutated receiving gefitinib (n = 195, 46.2%), erlotinib 123, 29.1%), or afatinib 104, 24.6%). The...

Background/Aim: Accumulated evidence has supported the hypothesis that functional polymorphisms of matrix metalloproteinases (MMP) were associated with risk various types cancer. However, few reports have studied contribution MMP-8 genotypes to either diagnostic or prognostic potential in lung In this study, we focused on a polymorphism promoter region (C-799T) and two non-synonymous (Val436Ala Lys460Thr) cancer risk. Patients Methods: Genomic DNA was isolated from peripheral blood 358...

The role of advanced bronchoscopic diagnostic techniques in the detection and staging lung cancer has increased sharply recent years. development endobronchial ultrasound (EBUS) improved minimally invasive mediastinal diagnosis peripheral lesions (PLLs). We investigated impact using EBUS as a method for tissue acquisition patients.In single center observational retrospective study, 3712 subjects were diagnosed with from 2003 to 2013 (EBUS was introduced 2008). Thus, we divided data into two...

Several kinds of inotropes have been used in critically ill patients to improve hemodynamics and renal dysfunction after cardiac surgery; however, the treatment strategies for reducing mortality increasing protection who underwent surgery remain controversial. Therefore, we performed a comprehensive network meta-analysis overcome lack head-to-head comparisons. A systematic database was searched up 31 December 2020, randomized controlled trials that compared different on outcomes protective...

Background: Long-acting muscarinic antagonist (LAMA) tiotropium improved lung function and reduced risks of exacerbation when added on to inhaled corticosteroids (ICS) with or without long-acting B2 agonists (LABAs) in patients uncontrolled asthma. However, studies predicting the effectiveness based patients’ clinical characteristics were limited. Methods: We conducted this retrospective study at a single medical center from July 2016 2017, used asthma control test (ACT) evaluate add-on...

Atrial fibrillation (AF), the most common sustained arrhythmia requiring treatment worldwide, is one of major causes ischemic stroke. Although amiodarone commonly used for rhythm control in AF, its relationship with stroke has rarely been addressed. We evaluated 16,091 patients who were diagnosed AF (Classification Diseases, 9th Revision, Clinical Modification [ICD-9-CM] 427.31 and 427.32) between 1998 2011; date diagnosis was set as index date. Patients a history (ICD-9-CM 430–438) received...

Object . To compare the provision and effectiveness of dispatcher-assisted cardiopulmonary resuscitation (DACPR) in rural urban areas. Methods Patients with out-of-hospital cardiac arrest (OHCA) were prospectively registered Taichung. The 29 districts Taichung city divided into areas based on whether population density is more than 1,000 people per square kilometer. Prehospital data collected according to Utstein-style template, telephone auditory records by a dispatch center. Results 2,716...

Prevention of cardiorenal syndrome through treatment with inotropic agents remains challenging. This network meta-analysis evaluated the safety and renoprotective effects inotropes on patients advanced heart failure (HF) using a frequentist random-effects model. A systematic database search was performed until 31 January 2021, total 37 trials were included. Inconsistency, publication bias, subgroup analyses conducted. The levosimendan group exhibited significantly decreased mortality...

1Department of Orthopaedic Surgery, National Taiwan University and Hospital, No. 7, Chung-Shan South Road, Taipei 10043, Taiwan, Republic China. E-mail address for R.-S. Yang: [email protected]

According to several phase III studies, tiotropium [a long-acting muscarinic antagonist (LAMA)] is a well-tolerated add-on therapy inhaled corticosteroids (ICS) for asthmatics with or without the addition of beta2-agonists (LABAs). However, real-world studies based on clinical phenotypes predict long-term need as an are limited.This retrospective study conducted at single medical center in Taiwan from July 2016 2018. An asthma control test (ACT) applied uncontrolled evaluate effectiveness...

Patients with advanced esophageal cancer and airway involvement have a poor prognosis. Self-expandable metallic stent (SEMS) implantation via bronchoscopy can immediately relieve stenosis improve survival. The purpose of this study was to determine the factors that predict survival in patients due after SEMS implantation.We conducted retrospective from February 2007 October 2013 at university hospital. Forty-two were included. underwent flexible electrosurgery under bronchoscopic...

The eighth edition of the American Joint Committee on Cancer (AJCC) staging system for lung cancer was introduced in 2017 and included major revisions, especially stage III. For subgroup IIIA-N2 non-small-cell (NSCLC), surgical resection remains controversial due to heterogeneous disease entity. aim this study evaluate clinicopathologic features prognostic factors patients with completely resected NSCLC. We retrospectively evaluated 77 consecutive pathologic NSCLC (AJCC edition) who...

Purpose: Triple therapy versus dual for chronic pulmonary obstructive disease (COPD) can reduce symptoms, limit the risk of acute exacerbations (AEs) as well improve lung function. Currently, studies that feature clinically important deterioration (CID) a composite endpoint to assess need treatment intensification patients maintained on remained be scarce. Patients and Methods: This study is retrospective analysis (January 2014 January 2018) COPD presented with moderate severe AEs during...

Abstract Background Although lung protective strategy and adjunctive intervention are associated with improved survival in patients acute respiratory distress syndrome (ARDS), the implementation of effective therapies remains low. This study aimed to evaluate whether use business intelligence (BI) for real-time data visualization is an improvement therapy. Methods A retrospective observational cohort was conducted on ARDS admitted between September 2020 June 2021 at two intensive care units...

<b>Background:</b> Endobronchial cryoprobe biopsy (CB) allows safe sampling of airway lesions, with bigger specimens, excellent tissue preservation and high diagnostic accuracy. However, the utility CB in diagnosis exudative pleural effusion (EPE) during semi-rigid pleuroscope has not been widely discussed. The aim this study was thus to evaluate feasibility safety taking specimens by from parietal pleura pleuroscope. <b>Methods:</b> In a single-center, observational, prospective study,...

This real-world study evaluated the efficacy of once-daily long-acting β2-agonist (LABA)/long-acting muscarinic antagonist (LAMA) fixed-dose combinations (FDCs) for improving lung function in patients with chronic obstructive pulmonary disease (COPD). Patients COPD who were treated LABA/LAMA FDCs 12 months included. We their improvement after treatment different FDCs. A total 198 analyzed. 114 umeclidinium/vilanterol (UMEC/VIL); 34 indacaterol/glycopyrronium (IND/GLY); and 50...

<b>Background:</b> We hypothesized that specific sonographic features on endobronchial ultrasonography (EBUS) may differentiate sarcoidosis from other lymph nodes. In current study, the of sarcoidosis, lymphoma and tuberculosis nodes were compared. <b>Methods:</b> conducted a retrospective observational study to analyze patients with intrathoracic lymphadenopathy who underwent EBUS-guided transbronchial needle aspiration (TBNA). Sonographic such as nodal size, margin, echogenicity, presence...