A5101751422- Esophageal and GI Pathology
- Esophageal Cancer Research and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Gastric Cancer Management and Outcomes
- Gastrointestinal disorders and treatments
- Metastasis and carcinoma case studies
- Intracranial Aneurysms: Treatment and Complications
- Optical Imaging and Spectroscopy Techniques
- Cerebrovascular and Carotid Artery Diseases
- Renal Diseases and Glomerulopathies
- Gastrointestinal Tumor Research and Treatment
- Biliary and Gastrointestinal Fistulas
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Lung Cancer Diagnosis and Treatment
- Photoacoustic and Ultrasonic Imaging
- Pancreatic and Hepatic Oncology Research
- Neurological Disease Mechanisms and Treatments
- Nitric Oxide and Endothelin Effects
- Dysphagia Assessment and Management
- Congenital Diaphragmatic Hernia Studies
- Mesenchymal stem cell research
- Vasculitis and related conditions
- Cancer Diagnosis and Treatment
- Gastroesophageal reflux and treatments
- Sarcoma Diagnosis and Treatment
Kokura Memorial Hospital
2017-2025
Nakadōri General Hospital
1996-2023
Dai Nippon Printing (Japan)
2012-2022
Kishiwada City Hospital
2019-2021
Memorial Hospital of South Bend
2021
Nippon Medical School
2020
Kyoto University Hospital
2005-2019
Jichi Medical University
1998-2018
Jichi Medical University Saitama Medical Center
2012-2018
San Francisco VA Medical Center
2018
Periodontal ligament (PDL) contributes to maintaining homeostasis in periodontal tissues by supplying stem/progenitor cells. It has long been suggested that PDL stem cells/progenitors are located around blood vessels. Recently mesenchymal cells (MSCs) have isolated and cultured from vitro, although the location of is unclear. The purpose this study test characteristics human (PDLSCs) examine their similarity related vascular cell types, such as pericytes endothelial cells.PDLSCs were...
We characterized the genetic diversity of complete VP1 region coxsackievirus A16 (CA16) and enterovirus 71 (EV71) isolated from patients with hand, foot, mouth disease in Toyama 1981 to 2007 evaluate relationship between epidemics changes. The predominant genogroups CA16 changed B C 1995-1998, genogroup further subgenogroup C1 C2 around 2002, C3 2005-2007. subgenogroups EV71 isolates were classified into B1, B4, C1, 1983-1994, C4 1997-2006. However, changes amino acid sequences regions...
Periodontal disease is characterized by the destruction of tooth supporting tissues. Regeneration periodontal tissues using ex vivo expanded cells has been introduced and studied, although appropriate methodology not yet established. We developed a novel cell transplant method for regeneration ligament stem (PDLSC)-transferred amniotic membrane (PDLSC-amnion). The aim this study was to investigate regenerative potential PDLSC-amnion in rat defect model. Cultured PDLSCs were transferred onto...
Periodontal disease is chronic inflammation that leads to the destruction of tooth-supporting periodontal tissues. We devised a novel method ("cell transfer technology") cells onto scaffold surface and reported potential technique for regenerative medicine. The aim this study examine efficacy in regeneration fate transplanted cells. Human ligament stem (PDLSCs) were transferred decellularized amniotic membrane into defects rats. Regeneration tissues was examined by microcomputed tomography...
Adult neocortex contains dividing satellite glia population even though their characteristics and functions have still remained unknown. Nestin+/NG2+ cells as major fraction of glial express bicuculline-sensitive γ-aminobutyric acid A (GABAA) receptors receive GABAergic inputs. Due to high [Cl−]i, activation depolarized the then induced Ca2+ influx into them. To assess an effect this excitation, we looked for expression neurotrophic factors. Among them, detected brain-derived factor (BDNF)...
Abstract Aims There is currently no gold standard in evaluating frailty patients with heart failure (HF), and the prognostic value of according to Canadian Study Health Aging Clinical Frailty Scale (CFS) on mortality HF still unknown. Methods results Among consecutive 596 after their discharge from Kokura Memorial Hospital (Kitakyushu, Japan) during 2015, at was assessed CFS. Patients were classified into three groups: low ( N = 232, 38.9%), intermediate 230, 38.6%), high 134, 22.5%). The...
The pathogenic roles of glomerular deposition components the complement cascade in IgA nephropathy (IgAN) are not completely clarified. To investigate pathologic role pathways IgAN, two IgAN-prone mouse models were examined. Grouped ddY (gddY) mice showed significant high proteinuria, severe lesions, and extracellular matrix expansion compared with serum (HIGA) but similar intensity deposition. Glomerular activation classical, lectin, alternative was demonstrated by significantly stronger...
Abstract Aims Sodium‐glucose cotransporter 2 (SGLT2) inhibitors (SGLT2i) have demonstrated effectiveness in reducing cardiovascular death and heart failure hospitalization (HFH). However, the efficacy safety of SGLT2 elderly patients with poor general status, such as very low bodyweight or nutritional who are not included randomized controlled trials, has yet been examined. In a real‐world setting, introduction to is difficult decision make. We therefore examined these drugs setting. Methods...
Background and Objectives Multimodal treatment is commonly adopted for patients with a T4 esophageal cancer. This trial evaluated which therapy offered better survival: preoperative chemoradiotherapy (CRT) or postoperative CRT. Methods Forty-three cancer were enrolled in prospective study each patient decided themselves arm, CRT-followed-by-esophagectomy esophagectomy-followed-by-CRT. The Group received 36 Gy radiotherapy simultaneous chemotherapy using cisplatin (CDDP) 5-fluorouracil (5FU)...
<i>Background and Aims:</i> Patients with esophageal cancer often develop metastatic disease after resection generally receive cisplatin-based chemotherapy or chemoradiotherapy. The efficacy toxicity of the combination docetaxel, 5-fluorouracil (5-FU) cisplatin (DFC) as a second-line were evaluated in patients postoperative refractory to chemotherapy. <i>Patients Methods:</i> Twenty esophagectomy cispatin-based therapy included this study. DFC regimen consisted...
Background Accurate estimation of the glomerular filtration rate ( GFR ) is very important in clinical practice. Although renal inulin clearance C in) gold standard for measuring , procedure measurement complicated. Use ‐estimating equations has been increasing recently due to their simplicity. The objectives present study are analyze correlation between and other parameters investigate usefulness limitation. Methods Seventy‐two Japanese patients were enrolled this study. was measured by...
A 20-year-old man was admitted to hospital with episodes of passing painless bloody stools and syncope. When he arrived, in a state shock severe dehydration. Laboratory data showed hemoglobin (Hb) level 8.6 g/dL. Esophagogastroduodenoscopy colonoscopy did not show the cause bleeding.
Fcgamma receptors (FcgammaRs) may play an important role in positive and negative regulation of immune cell responses complex (IC) clearance. Mesangial IgG deposition circulating IgG/IgA-IC sera are observed patients with IgA nephropathy (IgAN). Therefore, the pathological roles IgG-IC IgAN have been discussed. On other hand, several studies identified FcgammaR polymorphisms (FcgammaRIIa, FcgammaRIIIa FcgammaRIIIb) that determine susceptibility to autoimmune diseases such as systemic lupus...
Since many nutrients, including the three major ones of glucose, dipeptides, and cholesterol, are mainly absorbed in small intestine, assessment their effects on intestinal tissue is important for study food absorption. However, cultured cell lines, such as Caco-2 cells, or animal models, which differ from normal human physiological conditions, generally used evaluation absorption digestion. Therefore, it necessary to develop an alternative vitro method more accurate analyses. In this study,...
Several reports have shown detection of recipient-type ABO histo-blood group antigens (r-ABOAg) in the liver allograft, which may represent either true intragraft chimerism or other events such as cell injury. Little is known about factors that affect timing and extent r-ABOAg expression graft. We examined 65 recipients who underwent nonidentical living donor transplantation (61 compatible, 4 incompatible). Ninety-seven postoperative specimens (71 episode biopsies, 16 protocol 10 explanted...