A5069847554- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Pancreatic function and diabetes
- Banking stability, regulation, efficiency
- Supply Chain and Inventory Management
- Cancer Research and Treatments
- Metabolism, Diabetes, and Cancer
- Cancer, Hypoxia, and Metabolism
- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- Drug Transport and Resistance Mechanisms
- E-commerce and Technology Innovations
- Scheduling and Optimization Algorithms
- Renal Transplantation Outcomes and Treatments
- Gold and Silver Nanoparticles Synthesis and Applications
- Bone and Dental Protein Studies
- Cancer therapeutics and mechanisms
- Advanced Nanomaterials in Catalysis
- Nuclear Structure and Function
- Helicobacter pylori-related gastroenterology studies
- Diabetes and associated disorders
- ATP Synthase and ATPases Research
- Genetics, Aging, and Longevity in Model Organisms
- Statistical Methods in Clinical Trials
University of Science and Technology of China
2018-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2025
Sir Run Run Shaw Hospital
2024
Zhejiang University
2024
Chinese Academy of Sciences
2012-2024
Guiyang Medical University
2024
Second Xiangya Hospital of Central South University
2015-2022
Central South University
2015-2022
Institute for Molecular Medicine Finland
2016
University of Helsinki
2016
5-Fluorouracil (5-FU) chemotherapy is widely used in the treatment of advanced colon cancer. However, development resistance to 5-FU a significant obstacle successful treatment. MicroRNA-34a (miR-34a) has been reported be downregulated number tumor types and also shown act as suppressor. mechanisms underlying biological effects miR-34a chemoresistance remain unclear. The present study showed that expression 5-FU-resistant cancer cells. In addition, cells exhibited upregulation lactate...
Abstract The COVID-19 pandemic precipitated a surge in the non-performing assets held by financial institutions, elevating systemic risk networks. Therefore, developing strategies to alleviate this risk, with focus on assets, has become research area of interest. Supported policies related Chinese insurance market, study proposes establishment disposal fund backed capital. This will invest institutions aim mitigating risk. Using linear threshold model, we identify an asymptotically optimal...
To assess the consequence of different degrees missing primary endpoint data for randomized controlled trials and to find influence factors. PubMed, Cochrane Library, EMBASE ClinicalTrials.gov were searched up Nov 30, 2023. We included drug-coated balloon/drug-eluted stent with angiographic outcomes as endpoint. The tipping-point analysis was used deal inconsistency rate, standardized effect size (SES) ratio result robustness. A total 101 included, which had 109 trial comparisons. Among...
The dysregulation of miR‑126 has been reported to correlate with the progression several cancer types. present study demonstrated that was significantly downregulated in prostate (PCa) tissues compared normal tissues. In vitro and vivo studies indicated forced overexpression suppressed proliferation PCa cell lines. Additionally, a Transwell assay showed enhanced expression inhibited metastasis vitro. Furthermore, pik3r2 confirmed be direct target PCa. It also shown upregulated this inversely...
Alterations in microRNA (miRNA) expression have been observed cells subjected to exogenous stresses, implying that miRNAs play an important role cellular stress response; however, the underlying mechanism is still largely unknown. In present study, we found miR-3928 was implicated response ionizing radiation. After exposed X-rays, increased 1.5 h and then decreased, meanwhile Dicer, a key component miRNA processing machinery, gradually. An oscillation of both mature Dicer mRNA from 2 3.5...
Reduced β-cell mass and impaired function are primary causes of all types diabetes. However, the intrinsic molecular mechanism that regulates growth remains elusive. Here, we demonstrate small GTPase Rheb1 is a critical regulator glucose-stimulated insulin secretion (GSIS) in β-cells. was highly expressed mouse human islets. In addition, β-cell-specific knockout reduced size by suppressing proliferation increasing apoptosis. tamoxifen-induced deletion β-cells had no significant effect on but...
Pancreatic β cell failure is a hallmark of diabetes. However, the causes remain incomplete. Here, we report identification tetranectin (TN), an adipose tissue-enriched secretory molecule, as negative regulator insulin secretion in cells TN expression stimulated by high glucose adipocytes via p38 MAPK/TXNIP/thioredoxin/OCT4 signaling pathway, and elevated serum levels are associated with treatment greatly exacerbates hyperglycemia mice suppresses glucose-stimulated islets. Conversely,...
Decreased functional β-cell mass is the hallmark of diabetes, but cause this metabolic defect remains elusive. Here, we show that levels growth factor receptor-bound protein 10 (GRB10), a negative regulator insulin and mTORC1 signaling, are markedly induced in islets diabetic mice high glucose-treated insulinoma cell line INS-1 cells. β-cell-specific knockout Grb10 increased improved function. Grb10-deficient β-cells exhibit enhanced signaling reduced dedifferentiation, which could be...
Background Toxicity is a major concern related to the clinical use of polymyxin B, and available safety data for renal transplant patients are limited. Aims We investigated B toxicity risk factors in patients. Methods A prospective study was performed on group who received intravenous between January 2018 August 2021. Polymyxin treatment monitored evaluate factors. Results total 235 courses were administered 213 Of these, 121 (51.5%) developed skin hyperpigmentation (SH), 149 (63.4%)...
This paper studies a stochastic inventory management problem for cross-border products, where capital-constrained retailers may choose short-term financing to purchase products. By introducing bonded warehouse and entrusted loan schemes, we develop optimal strategies retailers. Our results show that helps increase their procurement. Specifically, when capital levels are low, opt mixed option of loan. Furthermore, the in limits could weaken reliance on financing. Interestingly, financings...
Credit guarantees play a crucial role in facilitating financing for small and medium-sized enterprises by reducing lenders' credit risk. However, when an extensive guarantee network emerges, the potential risk contagion increases. To better investigate such characteristics of networks that have to exacerbate contagion, we propose payment clearing model based on supply chain system consisting capital-constrained firms suppliers. The results show product stagnation events occur, our proposed...
Silver nanoparticles (AgNPs) have superior plasmonic properties surpassing other metals. However, a long‐standing difficulty in valence/density‐tunable DNA grafting of AgNPs disfavors their use DNA‐directed nanoplasmonics. Herein close‐to‐ideal surface protection pristine against various notorious stability issues Ag is achieved based on multidentate weak nucleobase bindings non‐programming FSDNA (fish sperm DNA). This further allows thiolated with tunable valence/density AgNPs. The end‐on...
Silver nanoparticles (AgNPs) have superior plasmonic properties surpassing other metals. However, a long‐standing difficulty in valence/density‐tunable DNA grafting of AgNPs disfavors their use DNA‐directed nanoplasmonics. Herein close‐to‐ideal surface protection pristine against various notorious stability issues Ag is achieved based on multidentate weak nucleobase bindings non‐programming FSDNA (fish sperm DNA). This further allows thiolated with tunable valence/density AgNPs. The end‐on...
Introduction In recent years, China has been carrying out the Diagnosis Related Groups (DRGs) payment reform, which an impact not only on methods and medical expenses, but also behaviors of staff. Some these are unexpected by policymakers, such as turning away critically ill patients, disaggregating hospitalization costs, setting up disease groups with higher points, so on. This phenomenon attracted attention some scholars, who put forward a few positive intervention measures, mainly...
Shortage of kidney allografts is a major barrier to end-stage renal disease patients receiving transplantation, and it necessary enlarge the donor pool find better ways using available allografts. The global incidence nephrolithiasis increasing, affects approximately 10% adults worldwide, also donors. However, there little information about use cadaveric with nephrolithiasis. This study aims evaluate safety outcome transplantation from deceased donors