A5083553782- Cardiac Valve Diseases and Treatments
- Electrospun Nanofibers in Biomedical Applications
- Tissue Engineering and Regenerative Medicine
- Cardiac and Coronary Surgery Techniques
- Infective Endocarditis Diagnosis and Management
- Mechanical Circulatory Support Devices
- Infectious Aortic and Vascular Conditions
- Blood transfusion and management
- Aortic Disease and Treatment Approaches
- 3D Printing in Biomedical Research
- Cardiac Arrhythmias and Treatments
- Thin-Film Transistor Technologies
- Intensive Care Unit Cognitive Disorders
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cardiac Arrest and Resuscitation
- Cardiac Structural Anomalies and Repair
- Healthcare professionals’ stress and burnout
- Laser Material Processing Techniques
- Surface Roughness and Optical Measurements
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- COVID-19 Clinical Research Studies
- Platelet Disorders and Treatments
- Orthopedic Surgery and Rehabilitation
- Medical Malpractice and Liability Issues
- Cardiac, Anesthesia and Surgical Outcomes
University Hospital Magdeburg
2018-2025
Klinikum Magdeburg
2018-2025
Otto-von-Guericke University Magdeburg
2019-2024
University Hospital Leipzig
2023
University Hospital Cologne
2014-2017
University of Cologne
2015-2017
Polymet Jena
2016
Friedrich-Alexander-Universität Erlangen-Nürnberg
2014
Battelle-Institut ev
1991-1992
Battelle
1991
Cardiopulmonary bypass (CPB) provokes inflammation culminating in organ dysfunction and increased mortality. Recently, neutrophil extracellular traps (NETs) have been found to be involved a variety of cardiovascular diseases promoting tissue injury. Here, we aimed elaborate the proinflammatory potential circulating cell-free (cf)DNA patients undergoing cardiac surgery with CPB. Plasma was collected pre- postoperatively as well at d1, d3, d5 d8 after surgery. At cfDNA levels significantly...
In this study, we contrast the impacts of surface coating bacterial nanocellulose small-diameter vascular grafts (BNC-SDVGs) with human albumin, fibronectin, or heparin–chitosan upon endothelialization saphenous vein endothelial cells (VEC) progenitor (EPC) in vitro. one scenario, coated were cut into 2D circular patches for static colonization a defined inner area; another they mounted on customized bioreactor and subsequently perfused cell seeding. We evaluated by emerging metabolic...
Zusammenfassung Digitale Lehrinhalte sind nicht zuletzt vor dem Hintergrund der für 2025 geplanten Reform humanmedizinischen Approbationsordnung gefordert und im Trend. Im Rahmen eines Pilotprojektes haben wir ein Logbuch Studierende „Praktischen Jahr“ (PJ) digitalisiert evaluiert. Ziel vorliegenden Arbeit ist es, das digitale PJ-Logbuch zu evaluieren. Basierend auf einem gedruckten wurde digitales als Web-App entwickelt. Die Umsetzung erfolgte mit kommerziellen...
Aims. Cardiac surgery leads to major post-operative changes in metabolism, but their exact nature and the underlying risk factors remains obscure. We aimed characterize plasma metabolites after coronary artery bypass grafting (CABG) identify intra- for global specific alterations post-operatively. Methods. performed a targeted metabolomic screen on samples from patients undergoing on-pump CABG disease (CAD) (n=24), collected 1 day before post-op days 1, 3, 7. assessed correlations with...
Although there is poor scientific evidence that working with occlusive gloves as damaging wet work, prolonged glove occlusion considered to be a risk factor for developing hand eczema similar work. To assess the effects of wearing during whole day, without exposure any additional hazardous substances, on skin condition and barrier function. We investigated 323 employees semiconductor production company in Germany: 177 clean‐room workers shift (exposed group) 146 administration (control...
There is an increasing need for small diameter vascular grafts with superior host hemo- and cytocompatibilities, such as low activation of platelets leukocytes. Therefore, we aimed to investigate whether the preparation bacterial nanocellulose different inner surfaces has impact on in vitro cytocompatibility.We have synthesized five a bioreactor, namely open interface surface (OIS), inverted (INV), partially air dried (PAD), formed contact (SAC) standard (STD) that were characterized by...
Closure of the left atrial appendage is a common procedure for patients with fibrillation undergoing cardiac surgery. The technique occlusion (LAAO) by an extracardiac clip (AtriClip) established as reliable method. Acute coronary obstruction circumflex artery has already been described after minimally invasive LAAO. Here, we report case delayed open-heart A patient who had mitral and tricuspid valve surgery in combination AtriClip implantation suffered from myocardial infarction 24 h...
The aim of this Pilot study was to investigate the cardiac surgical residents' workload during different teaching interventions and compare their stress levels with other working time spent in intensive care unit or normal ward.
Revascularization via coronary artery bypass grafting (CABG) to treat cardiovascular disease is established as one of the most important lifesaving surgical techniques worldwide. But shortage in functionally self-adaptive autologous arteries leads circumstances where clinical reality must deal with fighting pathologies coming from mismatching biophysical functionality more available venous grafts. Synthetic biomaterial-based CABG grafts did not make it market yet, what mostly due technical...
Multivessel coronary artery disease (CAD) is characterized by underlying chronic vascular inflammation and occlusion in the arteries, where these patients undergo bypass grafting (CABG). Since post-cardiotomy a well known phenomenon after CABG, attenuation of this required to reduce perioperative morbidity mortality. In study, we aimed phenotype circulating frequencies intensities monocyte subsets migration markers, respectively, investigate plasma level inflammatory cytokines chemokines...
Scientific attempts to create the "ideal" small diameter vascular graft have been compared with "search of holy grail." Prosthetic material as expanded polytetrafluoroethylene or Dacron shows acceptable patency rates large caliber vessels, while (< 6 mm) prosthetic conduits present unacceptably poor rates. Vascular tissue engineering represents a promising option address this problem. Thirty-two female Texel-sheep aged months 2 years underwent surgical common carotid artery (CCA)...
In this study, the hemocompatibility of tubes with an inner diameter 5 mm made polyvinyl chloride (PVC) and coated different bioactive conjugates was compared to uncoated PVC tubes, latex a stent for intravascular application that placed inside tubes. Evaluation done using in vitro hemodynamic loop model is recommended by ISO standard 10993-4. The were cut into segments identical length closed form loops avoiding any gap at splice, then filled human blood rotated water bath 37 °C 3 hours....
In this study, the hemocompatibility of tubes with an inner diameter 5 mm made polyvinyl chloride (PVC) and coated different bioactive conjugates was compared to uncoated PVC tubes, latex a stent for intravascular application that placed inside tubes. Evaluation done using in vitro hemodynamic loop model is recommended by ISO standard 10993-4. The were cut into segments identical length closed form loops avoiding any gap at splice, then filled human blood rotated water bath 37 °C 3 hours....
Background Though laser guided extractions of cardiac implantable electronic devices leads have become a routine procedure, the severe complications are associated with high mortality. Here, we report our single center experience using uniportal video-assisted thoracoscopy for lead extraction and compare it to stand-alone extraction. Methods The intraoperative data postoperative clinical outcomes patients undergoing concomitant ( N = 28) or without 43) in institution were analyzed...
Introduction: Small diameter artificial or tissue engineered blood vessels (TEBV) remain one of the most challenging tasks in cardiovascular surgery to overcome problem that many patients do not have suitable autologous due previous harvest chronical vascular diseases.
Background: Cardiopulmonary bypass (CPB) exposes patients to nonphysiological conditions, leading significant alterations in organ function and health status of with coronary artery disease (CAD). Specifically, CPB activates various pro-inflammatory pathways imbalances redox homeostasis, causing drastic changes circulating metabolite profiles. Recent studies have underscored the potential metabolomics not only understand pathophysiological processes but also improve risk stratification...