A5026572427- Epilepsy research and treatment
- Pharmacological Effects and Toxicity Studies
- Mosquito-borne diseases and control
- SARS-CoV-2 and COVID-19 Research
- Viral Infections and Outbreaks Research
- Vaccine Coverage and Hesitancy
- Hemoglobinopathies and Related Disorders
- HIV Research and Treatment
- Tuberculosis Research and Epidemiology
- Viral Infections and Vectors
- Virology and Viral Diseases
- Viral gastroenteritis research and epidemiology
- Vibrio bacteria research studies
- Healthcare Systems and Reforms
- vaccines and immunoinformatics approaches
- Global Maternal and Child Health
- Mental Health Treatment and Access
- Healthcare Policy and Management
- Immune responses and vaccinations
- Infectious Encephalopathies and Encephalitis
- Venomous Animal Envenomation and Studies
- Streptococcal Infections and Treatments
- Chronic Disease Management Strategies
- Immunodeficiency and Autoimmune Disorders
- Bacterial Infections and Vaccines
Ghent University Hospital
2020-2024
Ghent University
2022-2024
UCB Pharma (Belgium)
2012-2023
KU Leuven
1981-2022
Rega Institute for Medical Research
2001-2022
UCB Pharma (Netherlands)
2020
Sanofi (France)
2008-2009
The University of Texas Medical Branch at Galveston
2009
Emweb (Belgium)
2008
Sanofi (Mexico)
2006
The live yellow fever vaccine (YF-17D) offers a unique opportunity to study memory CD8(+) T cell differentiation in humans following an acute viral infection. We have performed comprehensive analysis of the virus-specific response using overlapping peptides spanning entire genome. Our results showed that YF-17D induces broad targeting several epitopes within each protein. identified dominant HLA-A2-restricted epitope NS4B protein and used tetramers specific for this track over 2 year period....
The expanding pandemic of coronavirus disease 2019 (COVID-19) requires the development safe, efficacious and fast-acting vaccines. Several vaccine platforms are being leveraged for a rapid emergency response1. Here we describe candidate (YF-S0) severe acute respiratory syndrome 2 (SARS-CoV-2) that uses live-attenuated yellow fever 17D (YF17D) as vector to express noncleavable prefusion form SARS-CoV-2 spike antigen. We assess safety, immunogenicity efficacy in several animal models. YF-S0...
The live attenuated yellow fever vaccine 17D (YF-17D) is one of the most effective vaccines. Despite its excellent safety record, some cases viscerotropic adverse events develop, which are sometimes fatal. mechanisms underlying such remain a mystery. Here, we present an analysis immunologic and genetic factors driving disease in 64-year-old male who developed symptoms.We obtained clinical, serologic, virologic, data on this case patient.Viral RNA was detected blood 33 days after vaccination,...
In 1999-2000, reports of fatalities after vaccination with 17D-derived yellow fever vaccine (YEL) focused mainly on cases YEL-associated adverse events (YEL-AEs) and viscerotropic disease (YEL-AVD). Here, we investigated 6 recent European to provide insight regarding immune response involvement identify potential risk factors.Clinical, microbiological, molecular biological, immunological assays were performed serum from patients YEL-AEs, including 5 YEL-AVD 1 neurotropic (YEL-AND).The levels...
ABSTRACT Yellow fever (YF) vaccines (17D-204 and 17DD) are well tolerated cause very low rates of severe adverse events (YEL-SAE), such as serious allergic reactions, neurotropic diseases (YEL-AND), viscerotropic (YEL-AVD). Viral host factors have been postulated to explain the basis YEL-SAE. However, mechanisms underlying occurrence YEL-SAE remain unknown. The present report provides a detailed immunological analysis 23-year-old female patient. patient developed suspected case YEL-AVD with...
With very little direct biological data of HIV-1 from before the 1980s, far-reaching evolutionary and epidemiological inferences regarding long prediscovery phase this pandemic are based on extrapolations by phylodynamic models genomic sequences gathered mostly over recent decades. Here, using a sensitive multiplex RT-PCR assay, we screened 1,645 formalin-fixed paraffin-embedded tissue specimens collected for pathology diagnostics in Central Africa between 1958 1966. We report near-complete...
Abstract Background and purpose In Rwanda, epilepsy prevalence ranges between 29‰ 49‰. Many women living with (WwE) are of childbearing age. Epilepsy characteristics management, contraception, pregnancy, puerperium stigma in WwE presenting at the neurology clinic Ndera, were investigated. Methods This prospective cross‐sectional study investigated demographics, characteristics, treatment, folic acid use, aged ≥18 years. Subgroups analysed by status any pregnancy time diagnosis relative to...
This study, supported by the Rwandan Ministry of Health and World Organization, was conducted in 2005 to determine prevalence epilepsy its sociocultural perception Rwanda, as well epilepsy-related knowledge practices health-care professionals (HCPs). A cross-sectional, nationally representative survey throughout Rwanda trained investigators. Participants were recruited random cluster sampling based on organization administrative units country. Overall, 1137 individuals (62% from rural areas)...
Patient satisfaction is an important outcome measure of health service and one the main reasons for gradual deterioration doctor-patient relationships in China. This study used standardized patient (SP) method to explore its provider-related determinants among primary facilities rural China.The dataset comprised 1138 clinic cases 728 31 counties, spread across four provinces. Information regarding consultation interaction between unannounced SPs physicians was recorded. gathered from...
BackgroundRecommended treatment for severe rabies exposure in unvaccinated individuals includes wound cleaning, administration of immunoglobulins (RIG), and vaccination. We conducted a survey outcomes the Philippines.MethodsThis was case series involving 7,660 patients (4 months to 98 years age) given purified equine RIG (pERIG) at Research Institute Tropical Medicine (Muntinlupa, Philippines) from July 2003 August 2004 following Category II or III exposures. Data on local systemic adverse...
Epilepsy remains the most frequent diagnosis in Psychiatric and Mental Health Services Mozambique. Because it is a major concern, 2013 Program for "Reducing Treatment gap" was launched 16 districts of five provinces covering population over 1.9 million. Using WHO Gap (mhGAP), pilot developed to provide effective quality care treatment people with epilepsy at primary health level. Implementation against background shortage human resources trained address difficulties availability...
We evaluated whether coadministration of the yellow fever (YF) virus vaccine with human immunoglobulin (Ig) that contained YF virus-neutralizing antibodies would reduce post-vaccination viremia without compromising immunogenicity and thus, potentially mitigate vaccine-associated adverse events. randomized 80 participants to receive either Ig or saline placebo. Participants were followed for 91 days safety assessments immunogenicity. There no differences found between two groups in proportion...
Patients with epilepsy (PwE) have an increased risk of active and lifetime depression. Two in 10 patients experience Lack trained psychiatric staff low- middle-income countries (LMIC) creates a need for screening tools that enable detection depression PwE. We describe the translation, validity reliability assessment Patient Health Questionnaire-9 (PHQ-9) as tool among PwE Rwanda.PHQ-9 was translated to Kinyarwanda using translation-back translation validated by discussion group. For...
Abstract The explosively expanding COVID-19 pandemic urges the development of safe, efficacious and fast-acting vaccines to quench unrestrained spread SARS-CoV-2. Several promising vaccine platforms, developed in recent years, are leveraged for a rapid emergency response 1 . We employed live-attenuated yellow fever 17D (YF17D) as vector express prefusion form SARS-CoV-2 Spike antigen. In mice, candidate, tentatively named YF-S0, induces high levels neutralizing antibodies favorable Th1...
The antibody responses and reactogenicity of a measles, mumps rubella vaccine in 9-month-old 15-month-old black children South Africa were compared. response to the measles component was marginally better older group, but no differences observed components. Reactogenicity similar two age groups. Therefore it is possible that trivalent vacine can safely effectively replace routine immunization at 9 months this population. Whether policy should incorporate such depends on extent acceptance...
Abstract Objectives Up to 85% of people living with epilepsy (PwE) reside in low‐and middle‐income countries. In sub‐Saharan Africa, the lifetime prevalence is 16 per 1000 persons. Northern rural Rwanda, a 47.7 has been reported. As variations across geographical areas have observed, we studied Southern Rwanda using same robust methodology as applied North. Methods We conducted three‐stage, cross‐sectional, door‐to‐door survey two villages from June 2022 April 2023. First, trained...