A5107410950- Advancements in Transdermal Drug Delivery
- Contact Dermatitis and Allergies
- Lipid Membrane Structure and Behavior
- Dermatology and Skin Diseases
- Surfactants and Colloidal Systems
Martin Luther University Halle-Wittenberg
2021-2025
Technical University of Darmstadt
2025
The main lipid compounds of the outermost layer human skin are ceramides (CERs), free fatty acids, and cholesterol. Although numerous studies performed in past could demonstrate importance these lipids for an intact barrier function, knowledge about impact each single component on lamellar films is still lacking. Especially, CERs a very heterogeneous group with high relevance proper barrier. It was found that reason stability lamellae related to structure type extent interactions between...
The stratum corneum (SC) is the largest physical barrier of human body. It protects against physical, chemical and biological damages, avoids evaporation water from deepest skin layers. For its correct functioning, homeostasis SC lipid matrix fundamental. An alteration composition in particular ceramide (CER) fraction can lead to development pathologies such as atopic dermatitis psoriasis. Different studies showed that direct replenishment lipids on damaged had positive effects recovery...
The stratum corneum represents the first skin barrier against chemical and physical damage. These unique properties are based on its peculiar lipid composition with ceramides (CERs) as main protagonists. In this study, structural of α-OH phytosphingosine [AP] CER class have been investigated. CERs present in their d-forms; however, most model systems diastereomer mixture synthetically produced l-form is used. d-form well-known to form a hydrogen bonding network that helps reduce permeability...