A5043150287- Ovarian cancer diagnosis and treatment
- PARP inhibition in cancer therapy
- BRCA gene mutations in cancer
- SARS-CoV-2 and COVID-19 Research
- PI3K/AKT/mTOR signaling in cancer
- COVID-19 epidemiological studies
- COVID-19 Clinical Research Studies
- Congenital Heart Disease Studies
- COVID-19 Pandemic Impacts
- Air Quality and Health Impacts
- SARS-CoV-2 detection and testing
- Dermatological and COVID-19 studies
- Viral gastroenteritis research and epidemiology
- Advanced Breast Cancer Therapies
- Chronic Lymphocytic Leukemia Research
- Tracheal and airway disorders
- Viral Infections and Outbreaks Research
- Biosimilars and Bioanalytical Methods
- CAR-T cell therapy research
- COVID-19 impact on air quality
- Vascular Procedures and Complications
- Atmospheric chemistry and aerosols
- Heart Rate Variability and Autonomic Control
- Cardiac Arrhythmias and Treatments
- Renal cell carcinoma treatment
All India Institute of Medical Sciences
2018-2025
Lovely Professional University
2021-2024
CARE Hospitals
2024
Ocera Therapeutics (United States)
2024
Sardar Vallabhbhai Patel University of Agriculture & Technology
2024
Sher-e-Kashmir University of Agricultural Sciences and Technology of Kashmir
2024
University of Petroleum and Energy Studies
2024
AstraZeneca (United Kingdom)
2018-2023
Hemwati Nandan Bahuguna Garhwal University
2021-2023
Cedars-Sinai Medical Center
2023
The rapid emergence of coronavirus disease 2019 (COVID-19) as a global pandemic affecting millions individuals globally has necessitated sensitive and high-throughput approaches for the diagnosis, surveillance, determining genetic epidemiology SARS-CoV-2. In present study, we used COVIDSeq protocol, which involves multiplex-PCR, barcoding, sequencing samples detection deciphering We approach on 752 clinical in duplicates, amounting to total 1536 could be sequenced single S4 flow cell NovaSeq...
Preliminary data from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia patients indicate that a cytokine storm may increase morbidity and mortality. Tocilizumab (anti-IL-6R) is approved by the Food Drug Administration for treatment of associated with chimeric antigen receptor T-cell therapy. Here we examined compassionate use tocilizumab in SARS-CoV-2 pneumonia.
Abstract Purpose: The efficacy, safety, and tolerability of cediranib plus olaparib (cedi/ola) were investigated in patients with nongermline–BRCA-mutated (non-gBRCAm) platinum-resistant recurrent ovarian cancer. Patients Methods: PARP inhibitor–naïve women aged ≥18 years non-gBRCAm cancer, ECOG performance status 0–2, ≥3 prior lines therapy received 30 mg once daily 200 twice this single-arm, multicenter, phase IIb trial. primary endpoint was objective response rate (ORR) by independent...
ABSTRACT Background The detection of SARS-CoV-2 by real-time polymerase chain reaction (PCR) in respiratory samples collected from persons recovered COVID-19 does not necessarily indicate shedding infective virions. By contrast, the isolation using cell-based culture likely indicates infectivity, but there are limited data on correlation between and PCR. Here we review our experience to determine infectivity safe de-isolation patients. Methods 195 patients with diverse severity were tested...
Abstract Adavosertib selectively inhibits Wee1, which regulates intra-S and G2/M cell-cycle checkpoints. This study investigated dosing schedules for adavosertib monotherapy, determining the maximum tolerated dose (MTD) recommended Phase II (RP2D) in patients with advanced solid tumors. Patients received oral qd or bid on a 5/9 schedule (5 days treatment, 9 off) 14-day cycles, one of two 5/2 (weekly, 2 3 weeks) 21-day cycles. Safety, efficacy, pharmacokinetic analyses were performed....
2562 Background: Adavosertib (AZD1775; A) is a highly selective inhibitor of WEE1. This Phase I study (NCT02617277) investigated range doses and schedules for oral A plus IV durvalumab (DV), human monoclonal antibody targeting PD-L1, to determine the maximum tolerated dose (MTD) recommended II (RP2D) in patients (pts) with advanced solid tumors. Methods: Four 28-day (Sch) were evaluated pts receiving DV 1500 mg on day (d) 1 each schedule (Table). Patients continued treatment if they showed...
Abstract The rapid emergence of coronavirus disease 2019 (COVID-19) as a global pandemic affecting millions individuals globally has necessitated sensitive and high-throughput approaches for the diagnosis, surveillance determining genetic epidemiology SARS-CoV-2. In present study, we used COVIDSeq protocol, which involves multiplex-PCR, barcoding sequencing samples detection deciphering We approach on 752 clinical in duplicates, amounting to total 1536 could be sequenced single S4 flow cell...
Abstract Background: Preclinical data suggest that adavosertib (AZD1775), a highly selective Wee1 inhibitor, enhances the antitumor effect of PARP inhibitors such as olaparib. The dose-escalation part this Phase Ib study (NCT02511795) investigated safety and tolerability plus olaparib in patients (pts) with refractory solid tumors to determine maximum tolerated dose (MTD) recommended II (RP2D). Methods: Pts received (QD or BID) for 3 consecutive days 4 off treatment (3/4), 5 2 (5/2), (BID)...
5513 Background: Adavosertib (AZD1775; A), a highly selective WEE1 inhibitor, demonstrated activity and tolerability in combination with carboplatin (C) primary PROC. This study (NCT02272790) assessed the objective response rate (ORR) safety of A Methods: Pts recurrent RECIST v1.1 measurable PROC received C, gemcitabine (G), weekly paclitaxel (P), or pegylated liposomal doxorubicin (PLD) 3- 4-week (G, P, PLD) cycles (Table). Tumor assessments were performed every 2 until disease progression....
6056 Background: A Phase I trial (NCT01116648) of cediranib (cedi) in combination with olaparib (ola) (cedi + ola) demonstrated an overall response rate 44% patients (pts) recurrent ovarian cancer (OC), including pts without a deleterious or suspected gBRCAm (non-gBRCAm; Liu et al. Eur J Cancer 2013). The subsequent II showed significant improvement progression-free survival (PFS) cedi ola versus monotherapy platinum-sensitive OC pts, notably non-gBRCAm (Liu Lancet Oncol 2014). We report...
In the field of modern weather prediction, accurate classification is essential, impacting critical sectors such as agriculture, aviation, and water resource management. This research presents a forecasting model employing two influential classifiers random forest technique based on gradient boosting, both implemented using Scikit-learn library. Evaluation key metrics including F1 score, accuracy, recall, precision, with Gradient Boosting emerging superior choice for precipitation...
The WEE1 inhibitor adavosertib (AZD1775) has been investigated in Western patients. This open-label Phase Ib study (NCT02341456) the safety, pharmacokinetics, and clinical activity of combination with carboplatin alone or paclitaxel plus Asian patients advanced solid tumors defined recommended II dose. Nineteen received 175 mg twice daily (bid) for 2.5 days (five doses) (AUC 5) (175 mg/m2) carboplatin, 225 bid 21-day cycles. Preliminary safety dose-limiting toxicity analyses were performed...
Abstract Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), initially originated in China year 2019 and spread rapidly across the globe within 5 months, causing over 96 million cases of infection deaths. Huge efforts were undertaken to bring COVID-19 vaccines clinical development, so that it can be made available at earliest, if found efficacious trials. We developed a candidate vaccine ZyCoV-D comprising DNA plasmid vector carrying gene encoding spike protein (S) SARS-CoV-2...
<b>Background:</b> Anemia is a common complication of human immunodeficiency virus (HIV) infection. The role iron, Vitamin B12, and folate deficiencies, which are otherwise most causes anemia, not well-established in HIV patients. Several studies India have shown that severe associated with higher grade but correlation CD4 cell counts severity anemia well-documented. <b>Aims:</b> aims the present study were: To estimate point prevalence patients, to analyze causative deficiencies anemic...
Pulmonary congestion is a central feature of heart failure (HF) seen in acute decompensated state as well chronic stable disease. The present study sought to determine whether simplified cardiac magnetic resonance imaging (CMR)-derived lung water density (LWD) measurement has prognostic relevance predicting adverse cardiovascular outcomes patients with HF and left ventricular ejection fraction (LVEF)<50%.
Covid-19 pandemic is a novel disease with gradual emergence of its signs and symptoms. Oral healthcare providers had setback in their dental practices due to the high rate infectivity risk contracting through patients carrying virus. Once practice resumed normalcy surgeons came across variety oral manifestations history Covid post recovery. An attempt made recognise plausible explanation mechanism development such signs.
By using 16 simple sequence repeat (SSR) markers, the genetic relatedness of 21 exceptional walnut genotypes was assessed. A significant degree diversity observed within a given population, as indicated by number alleles per locus ranging from 2 to 4. WGA-1, WGA-4, and WGA-79 contained greatest (4), followed WGA-118, WGA-202, WGA-42. Conversely, WGA-27, WGA-69, WGA-32 fewest alleles. The range PIC value 0.11 0.38. Using model-based cluster analysis, all were categorized into two primary...