A5103023744- Sarcoma Diagnosis and Treatment
- Bone Tumor Diagnosis and Treatments
- Bone health and treatments
- Bone fractures and treatments
- Oral and Maxillofacial Pathology
- Reconstructive Surgery and Microvascular Techniques
- Bone Metabolism and Diseases
- Management of metastatic bone disease
- Knee injuries and reconstruction techniques
- Total Knee Arthroplasty Outcomes
- Neurofibromatosis and Schwannoma Cases
- Orthopedic Infections and Treatments
- Musculoskeletal synovial abnormalities and treatments
- Cancer Diagnosis and Treatment
- Orthopaedic implants and arthroplasty
- Vascular Malformations and Hemangiomas
- Genetics, Bioinformatics, and Biomedical Research
- Bone and Joint Diseases
- Tendon Structure and Treatment
- Testicular diseases and treatments
- Surgical site infection prevention
- Vascular Tumors and Angiosarcomas
- Cancer-related molecular mechanisms research
- Organ and Tissue Transplantation Research
- Orthopedic Surgery and Rehabilitation
University of Arkansas for Medical Sciences
2013-2023
Winthrop Rockefeller Foundation
2011-2023
Arkansas Children's Hospital
2007-2021
University of Arkansas Medical Center
2017-2018
Musgrave Park Hospital
2018
Orthopedic One
2016
St Nicholas Hospital
2011
Wycombe General Hospital
2011
Medical Education Institute
2011
Musculoskeletal Transplant Foundation
2005
An increase in osteoblast and osteocyte apoptosis has been demonstrated mice humans receiving glucocorticoids may be involved the pathogenesis of associated osteonecrosis. To examine spatial relationship between glucocorticoid-induced osteonecrosis, we determined prevalence whole femoral heads obtained from patients who underwent prosthetic hip replacement because osteonecrosis due to chronic glucocorticoid treatment (n = 5), alcoholism 3), trauma 1) as well neck cores with sickle cell...
BACKGROUND Patients with Ewing sarcoma require local primary tumor control surgery, radiation, or both. The optimal choice of for overall and disease remains unclear. METHODS localized bone who were treated on 3 consecutive protocols standard‐dose, 5‐drug chemotherapy every weeks included (n=465). Propensity scores used to differences between groups by constructing multivariate models assess the impact type clinical endpoints (event‐free survival [EFS], survival, failure, distant failure)...
Prognosis is poor for Ewing sarcoma patients with metastasis at diagnosis. We intensified a five-drug therapy (ifosfamide, etoposide alternated vincristine, doxorubicin, and cyclophosphamide) using filgrastim but not stem-cell support. studied topotecan alone combined cyclophosphamide in therapeutic windows before the therapy. A randomly assigned proportion of received amifostine as cytoprotective agent.Eligible were < or = 30 years old had histologically proven primitive neuroectodermal...
We evaluated the biomechanical properties of patellar tendon allografts from donors aged 18 to 55 years. Bone-patellar tendon-bone complexes were harvested acceptable and processed. Fat soft tissue removed, tendons sectioned lengthwise leaving central third. Area measure ments taken, mechanical testing was per formed. Specimens pulled failure at a rate 10% initial length second. The force failure, tensile stress, modulus elasticity, percent elon gation determined for each specimen. There no...
Stagnant blood flow present in slow-flow vascular malformations can lead to localized intravascular coagulopathy (LIC), measured by elevated D-dimer levels, low fibrinogen, and/or thrombocytopenia. LIC thrombosis bleeding, resulting pain, swelling, and functional limitations. Patients with complex treated sirolimus show clinical improvement these symptoms. We hypothesized that the benefits of may correlate improvements coexisting LIC.A retrospective chart review was performed, including...
The finding of a cytogenetic-pathologic correlation between complex karyotypes and high grade cartilaginous tumors has been reported. However, few cytogenetic reports exist regarding benign or low lesions. A subset malignant is characterized by locally aggressive behavior but no metastatic potential. Because the histopathologic distinction benign, borderline, lesions can be difficult, additional tumor markers associated with clinical borderline could clinically significant.Four tumors,...
Osteosarcoma (OS) is the most common malignant bone tumor affecting children and adolescents. Many patients are treated with a combination of chemotherapy, resection, limb salvage protocols. Surgical reconstructions after resection include structural allografts, non-cemented endoprostheses, distraction osteogenesis (DO), which require direct formation. Although cisplatin (CDP) extensively used for OS effects on regeneration not well studied. The CDP formation in DO were compared using two...
Little Rock, Ark. From the Division of Plastic Surgery, Department and Orthopaedics, University Arkansas for Medical Sciences. Received publication February 8, 2000; revised April 18, 2000. James C. Yuen, M.D. 4301 W. Markham, Slot 720 72205-7199[email protected]
Intramedullary extendable Bailey-Dubow nails were used for treatment of lower extremity deformities resulting from osteogenesis imperfecta. Sixteen patients had 56 placed in 48 long bones, including 18 revisions. All braced postoperatively. The average duration follow-up was 4.8 years. Nine who nonambulatory preoperatively walked braces Despite a high rate complication, provide correction the angular imperfecta, decrease fracturing, and allow most previously children to walk.
Producing quality slides of paraffin embedded, decalcified bone depends on the interaction several independent mechanisms that all must work in concert. Grossing, fixation, decalcification, processing, embedding, sectioning, and staining each comprise a unique procedure when examining slide. A system integrates these concepts proven workable formula is essential for specimen management necessary greater reproducibility. thorough understanding component to tailor variety hard tissue types...
Does a link exist between obesity and soft-tissue sarcoma outcomes? We hypothesized that sarcomas in patients with may lead to larger tumors at detection, an increased risk for more complex surgical excision, wound healing-related complications, higher stage presentation, decreased survival.One hundred thirty-nine were retrospectively evaluated over 10 years. Patients divided into 2 cohorts based on the World Health Organization body mass index (BMI) grouping. A BMI ≥ 30 kg/m2 was classified...
We describe a primary aneurysmal bone cyst (ABC) of the soft tissue distal thigh in 10-year-old girl. Radiographs showed an oblong density that was consistent with hemorrhage or calcification; underlying unremarkable. Pathologic findings were myositis ossificans on gross examination, but numerous hemorrhagic cysts present lesion. Histopathologic features ABC. Cytogenetic analysis tumor revealed 46,XX,t(5;17)(q33;p13); 17p13 breakpoints have been reported intraosseous Thirteen months after...
To assess the potential of using distraction osteogenesis to reconstruct bone deficient limbs after limb salvage for musculoskeletal sarcomas, authors examined effect methotrexate on in a rabbit tibial lengthening model. Eighteen rabbits underwent corticotomy and application ring external fixator. Rabbits were assigned randomly one two groups which either (n = 12) or placebo 6) was administered during 21-day period. Serum levels complete blood cell counts monitored distraction, radiographs...
Abstract: Primary cutaneous sweat gland carcinomas (SGCs) are rare tumors that commonly involve axillae, have a high local recurrence rate, and rarely show sarcomatoid transformation. A 68-year-old man presented with rapid enlargement of previously stable, asymptomatic pea-sized nodule in the left axilla. Initial excision (with positive surgical margins) at another institution showed characteristic histologic features high-grade osteosarcoma molecular analysis using 92-gene real-time...
Osteolytic bone lesions are a hallmark of multiple myeloma (MM) disease. Bone destruction is associated with severely imbalanced remodeling, secondary to increased osteoclastogenesis and significant osteoblast suppression. Lytic the pelvis relatively common in MM patients known contribute morbidity because high risk fracture, which frequently demands extensive surgical intervention. After observing unexpected radiological improvement serial large pelvic CT assessment patient treated total...
Abstract Background/Objectives Slow‐flow vascular malformations are abnormal vessels that can lead to activation and consumption of coagulation factors thrombosis, known as localized intravascular coagulopathy (LIC). Most clinical research evidence malformation hemostasis relies on conventional studies, which may not provide a complete picture. Thromboelastograpy (TEG) is tool real‐time assessment patient's dynamics, allow for more individualized treatment approach. We hypothesized patients...