A5105348009- Neural dynamics and brain function
- Neuroscience and Neuropharmacology Research
- Neuroscience and Neural Engineering
- Advanced Memory and Neural Computing
- stochastic dynamics and bifurcation
- Neuroscience and Music Perception
- Photoreceptor and optogenetics research
- Memory and Neural Mechanisms
- Neural Networks and Applications
- Nonlinear Dynamics and Pattern Formation
- Hearing Loss and Rehabilitation
- Neurobiology and Insect Physiology Research
- Control and Dynamics of Mobile Robots
- EEG and Brain-Computer Interfaces
- Olfactory and Sensory Function Studies
- Topological and Geometric Data Analysis
- Adaptive Control of Nonlinear Systems
- Analog and Mixed-Signal Circuit Design
- Adipose Tissue and Metabolism
- Advanced Fiber Laser Technologies
- Biochemical effects in animals
- Mechanical Circulatory Support Devices
- Advanced Surface Polishing Techniques
- Advanced Differential Equations and Dynamical Systems
- Quantum Information and Cryptography
New York University
2011-2025
Center for Neuro-Oncology
2016-2017
Universitat Politècnica de Catalunya
2013-2014
Clínica Dávila
2010
Northwestern University
2002
Max Planck Institute for Medical Research
1999
Max Planck Society
1998
University of Washington
1993
University of Chicago
1985
Correlated spiking is often observed in cortical circuits, but its functional role controversial. It believed that correlations are a consequence of shared inputs between nearby neurons and could severely constrain information decoding. Here we show theoretically recurrent neural networks can generate an asynchronous state characterized by arbitrarily low mean despite substantial amounts input. In this state, spontaneous fluctuations the activity excitatory inhibitory populations accurately...
The role of local cortical activity in shaping neuronal responses is controversial. Among other questions, it unknown how the diverse response patterns reported vivo —lateral inhibition some cases, approximately balanced excitation and (co-tuning) others—compare to spread synaptic connectivity. Excitatory inhibitory might cancel each out, or, whether one outweighs other, receptive field properties be substantially affected. As a step toward addressing this question, we used multiple...
Amplitudes of EPSPs evoked by repetitive presynaptic action potentials can either decrease (synaptic depression) or increase facilitation). To determine whether facilitation and depression in the connections between neocortical pyramidal cells varied with identity pre- postsynaptic cell they changed during postnatal development, whole-cell voltage recordings were made simultaneously from two three layers 2/3 5 rat sensorimotor cortex. Unitary when neurons same different layers. In young...
Neuronal firing is determined largely by incoming barrages of excitatory postsynaptic potentials (EPSPs), each which produce a transient increase in probability. To measure the effects weak inputs on probability cortical neurons, we compute phase-response curves (PRCs). PRCs, whose shape can be related to dynamics spike generation, document changes timing spikes caused an EPSP repetitively neuron as function when it arrives interspike interval (ISI). The PRC exactly poststimulus time...
We investigated the development of L2/3 pyramidal cell (PC) circuitry in juvenile mice from postnatal day 10 (P10) to P29. Using whole recordings an vitro thalamocortical slice preparation, we examined connection architecture and intrinsic synaptic properties PCs. The excitatory connections between PCs were highly localized: probability declined with intersomatic distance 0.18 about 0.05 over 150 μm, but did not vary age. However, mean variance changed dramatically P10 input resistance,...
1. The effects of small, brief depolarizing pulses and excitatory postsynaptic potentials (EPSPs) on neuronal firing were examined in layer V neurons slices cat sensorimotor cortex. During intracellular recording, current (duration, 0.5-2.0 ms; amplitude, 0.1-4.0 nA) injected to produce pulse (PPs) with a near-linear rise peak (0.08-3.6 mV; time = duration) followed by an exponential decay. These PPs resembled EPSPs evoked electrical stimulation adjacent sites. When that induced discharge...
The interplay between inhibition and excitation is at the core of cortical network activity. In many cortices, including auditory cortex (ACx), interactions excitatory inhibitory neurons generate synchronous gamma oscillations (30–70 Hz). Here, we show that differences in connection patterns synaptic properties excitatory–inhibitory microcircuits permit spatial extent inputs to modulate magnitude oscillations. Simultaneous multiple whole-cell recordings from connected fast-spiking...
Correlations in the spiking activity of neurons have been found many regions cortex under multiple experimental conditions and are postulated to important consequences for neural population coding. While there is a large body extracellular data reporting correlations various strengths, subthreshold events underlying origin magnitude signal-independent (called noise or spike count correlations) unknown. Here we investigate, using intracellular recordings, how synaptic input from shared...
1. The effects of excitatory postsynaptic potentials (EPSPs) on interspike intervals (ISIs) neocortical neurons can be mimicked by pulse (PPs) produced current injection. present report documents the dependence ISI shortening amplitudes PPs and EPSPs firing rate affected neuron. 2. In rhythmically necortical neurons, shortenings caused arriving at specific times in described a shortening-delay (S-D) curve. S-D curve yields three measures PPs' ability to shorten ISI: 1) mean shortening, S; 2)...
The frequency-intensity receptive fields (RF) of neurons in primary auditory cortex (AI) are heterogeneous. Some have V-shaped RFs, whereas others enclosed ovoid RFs. Moreover, there is a wide range temporal response profiles ranging from phasic to tonic firing. mechanisms underlying this diversity field properties yet unknown. Here we study the characteristics thalamocortical (TC) and intracortical connectivity that give rise individual cell responses. Using mouse TC slice preparation,...
Abstract It is postulated that synchronous firing of cortical neurons plays an active role in cognitive functions the brain. An important issue whether pyramidal different layers exhibit similar tendencies to synchronise. To address this issue, we performed intracellular and whole‐cell recordings regular‐spiking slice preparations rat motor cortex (18–45 days old) analysed phase response curves these 2/3 5. The curve represents how external stimulus affects timing spikes immediately after...
The time course of inhibition plays an important role in cortical sensitivity, tuning, and temporal response properties. We investigated the development L2/3 inhibitory circuitry between fast-spiking (FS) interneurons pyramidal cells (PCs) auditory thalamocortical slices from mice postnatal day 10 (P10) P29. found that maturation intrinsic synaptic properties both FS their connected PCs influence timescales inhibition. cell firing rates increased with age owing to decreased membrane...
To simplify theoretical analyses of neural networks, individual neurons are often modeled as Poisson processes. An implicit assumption is that even if the spiking activity each neuron non-Poissonian, composite obtained by summing many spike trains limits to a process. Here, we show analytically and through simulations this invalid. Moreover, with Fokker-Planck equations behavior feedforward networks reproduced accurately only tendency fire periodically incorporated using colored noise whose...
We use a combination of in vitro whole cell recordings and computer simulations to characterize the cellular synaptic properties that contribute processing auditory stimuli. Using mouse thalamocortical slice preparation, we record intrinsic membrane layer 3/4 regular-spiking (RS) pyramidal neurons fast-spiking (FS) interneurons primary cortex (AI). find postsynaptic potentials (PSPs) evoked FS cells are significantly larger depress more than those RS after thalamic stimulation. these data...
Analyses of idealized feedforward networks suggest that several conditions have to be satisfied in order for activity propagate faithfully across layers. Verifying these concepts experimentally has been difficult owing the vast number variables must controlled. Here, we cultured cortical neurons a chamber with sequentially connected compartments, optogenetically stimulated individual first layer high spatiotemporal resolution, and then monitored subthreshold suprathreshold potentials...
The responses of neurons in sensory cortex depend on the summation excitatory and inhibitory synaptic inputs. How inputs scale with stimulus depends network architecture, which ranges from lateral configuration where are more narrowly tuned than inputs, to co-tuned both equally. underlying circuitry that gives rise inhibition co-tuning is yet unclear. Using large-scale simulations experimentally determined connectivity patterns rate models, we show spatial extent input configuration: there...
Abstract Pavlovian aversive conditioning requires learning of the association between a conditioned stimulus (CS) and an unconditioned, (US) but also involves encoding time interval two stimuli. The neurobiological bases this are unknown. Here, we show that in rats, dorsal striatum basal amygdala belong to common functional network underlying temporal expectancy CS–US interval. Importantly, changes coherence local field potentials (LFPs) were found couple these structures during estimation...