A5005903784- Sarcoma Diagnosis and Treatment
- Bone Tumor Diagnosis and Treatments
- Management of metastatic bone disease
- Orthopaedic implants and arthroplasty
- Reconstructive Surgery and Microvascular Techniques
- Cellular Mechanics and Interactions
- Surgical site infection prevention
- Total Knee Arthroplasty Outcomes
- CAR-T cell therapy research
- Diamond and Carbon-based Materials Research
- Metal and Thin Film Mechanics
- Orthopedic Infections and Treatments
- Cancer-related gene regulation
- Foot and Ankle Surgery
- Knee injuries and reconstruction techniques
- Silk-based biomaterials and applications
- Shoulder and Clavicle Injuries
- Sports injuries and prevention
- Musculoskeletal synovial abnormalities and treatments
- Orthopedic Surgery and Rehabilitation
- Tendon Structure and Treatment
- Virus-based gene therapy research
- Vascular Tumors and Angiosarcomas
- Shoulder Injury and Treatment
- Ion-surface interactions and analysis
Moffitt Cancer Center
2022-2025
Duke Medical Center
2016-2024
Duke University
2014-2024
Mount Sinai Hospital
2023-2024
University of Toronto
2017-2024
Duke University Hospital
2016-2023
Sinai Health System
2022-2023
Cleveland Clinic
2023
Kokilaben Dhirubhai Ambani Hospital
2023
Meyer (China)
2021
A first-in-human phase 1 clinical trial of the PEGylated protease-activated fluorescent probe, LUM015, enables tumor imaging at a safe and tolerable dose in humans.
Abstract Background Historically, amputation was the primary surgical treatment for osteosarcoma of extremities; however, with advancements in techniques and chemotherapies limb salvage has replaced as dominant paradigm. This study assessed type resection chosen patients twenty-first century. Methods Utilizing largest registry osteosarcoma, National Cancer Database (NCDB), we retrospectively analyzed high grade extremities from 2004 through 2015. Differences between undergoing are described....
For many cancer types, survival is improved when patients receive management at treatment centers that encounter high numbers of annually. This correlation may be more important with less common malignancies such as sarcoma. Existing evidence, however, limited and inconclusive to whether facility volume associated in soft tissue sarcoma.The purpose this study was examine the association between overall sarcoma extremities. In investigating aim, we sought (1) differences characteristics high-...
In the United States, race and socioeconomic status are well known predictors of adverse outcomes in several different cancers. Existing evidence suggests that may impact survival soft tissue sarcoma (STS). We investigated National Cancer Database (NCDB), which contains medical variables largest patient registry to date. Our goal was determine race, ethnicity on patients with extremities (STS-E).We retrospectively analyzed 14,067 STS-E NCDB from 1998 through 2012. Patients were stratified...
CDH1 (also known as E-cadherin), an epithelial-specific cell-cell adhesion molecule, plays multiple roles in maintaining adherens junctions, regulating migration and invasion, mediating intracellular signaling. Downregulation of E-cadherin is a hallmark epithelial-to-mesenchymal transition (EMT) correlates with poor prognosis carcinomas. Conversely, upregulation prognostic for improved survival sarcomas. Yet, despite the benefit expression sarcoma, mechanistic significance sarcomas remains...
Retrospective review.To determine if adjuvant radiation therapy (RT) improves overall survival (OS) following surgical resection of chordomas.The role RT for the treatment chordomas remains incompletely described. Previous studies have not found to improve OS, but these did group patients based on margin status or dose modality. We used National Cancer Database investigate in resection.Patients were stratified (positive vs. negative). Utilizing Kaplan-Meier method, OS was compared between...
Use of molecular sequencing methods in periprosthetic joint infection (PJI) diagnosis and organism identification have gained popularity. Next-generation (NGS) is a potentially powerful tool that now commercially available. The purpose this study was to compare the diagnostic accuracy NGS, polymerase chain reaction (PCR), conventional culture, Musculoskeletal Infection Society (MSIS) criteria, recently proposed criteria by Parvizi et al PJI.In retrospective study, aspirates or tissue samples...
ATRX is one of the most frequently altered genes in solid tumors, and mutation especially frequent soft tissue sarcomas. However, role tumor development response to cancer therapies remains poorly understood. Here, we developed a primary mouse model sarcoma showed that Atrx-deleted tumors were more sensitive radiation therapy oncolytic herpesvirus. In absence Atrx, irradiated sarcomas had increased persistent DNA damage, telomere dysfunction, mitotic catastrophe. Our work also Atrx deletion...
We present our results with an INBONE I (Wright Medical, Memphis, TN) prosthesis that have a minimum of 4 to 10 years follow-up and include preoperative deformity analysis on outcomes.A consecutive series 149 patients, from 2007 2011, at single institution were enrolled. Pain patient-reported function assessed preoperatively yearly follow-ups. analyzed the data for complications, reoperations, failures (defined as undergoing revision exchange or removal one both metallic components any...
BACKGROUND: Burnout and professional satisfaction is an often overlooked component for healthcare outcomes; the COVID-19 pandemic represents unprecedented stressor that could contribute to higher levels of burnout. OBJECTIVES: Our primary objective was evaluate association a battery fulfillment, job change, concerns, coping measures. secondary determine whether fulfillment measures differed by gender experience among physician specialties. METHODS: The study purposive sample convenience....
Background . Although chondrosarcomas (CS) are mostly considered radioresistant, advancements in radiotherapy have brought attention to its use these patients. Using the largest registry of primary bone tumors, National Cancer Database (NCDB), we sought better characterize current CS patients and identify any potential survival benefit with higher radiation doses advanced therapies. Methods We retrospectively analyzed NCDB from 2004 2015 who underwent radiotherapy. The Kaplan–Meier method...
Multiple Myeloma represents a plasma cell disorder that can result in hallmark bony destructive change addition to other signs of myelomatous disease. Imaging often helps establishing the diagnosis and staging patient. There are several different imaging modalities provide levels insight into disease extent. We report unique case multiple myeloma where progressive nature patient's highlights strengths limitations approaches. Whole-body MRI noncontrast technique directly images bone marrow...
Background: Soft-tissue sarcomas (STSs) represent a heterogeneous group of malignancies with widely varying treatment responses and biological behaviors. While spontaneous necrosis (present at diagnosis) is recognized in established sarcoma grading systems, the prognostic significance therapy-induced remains uncertain. Inconsistent definitions, methodological variability, clinical confounders further complicate interpretation as an independent marker. Methods: This communication synthesizes...
The treatment of soft tissue sarcoma (STS) generally involves tumor excision with a wide margin. Although advances in fluorescence imaging make real-time detection cancer possible, removal is limited by the precision human eye and hand. Here, we describe novel pulsed Nd:YAG laser ablation system that, when used conjunction previously described molecular system, can identify ablate vivo. Mice primary STS were injected protease-activatable probe LUM015 to label tumors. Resected tissues from...
Objective To assess the ability of a novel imaging system designed for intraoperative detection residual cancer in tumor beds to distinguish neoplastic from normal tissue dogs undergoing resection soft sarcoma (STS) and mast cell (MCT). Study Design Non‐randomized prospective clinical trial. Animals 12 with STS 7 MCT. Methods A fluorescent agent that is activated by proteases vivo was administered 4–6 or 24–26 hours before resection. During surgery, handheld device used measure fluorescence...
The preoperative grading of chondrosarcomas bone that accurately predicts surgical management is difficult for surgeons, radiologists, and pathologists. There are often discrepancies in grade between the initial biopsy final histology. Recent advances use imaging methods have shown promise ability to predict grade. most important clinical distinction 1 chondrosarcomas, which amenable curettage, resection-grade (grade 2 3) require en bloc resection. aim this study was evaluate a Radiological...