A5068276723- Pancreatic and Hepatic Oncology Research
- MRI in cancer diagnosis
- Radiomics and Machine Learning in Medical Imaging
- Advanced MRI Techniques and Applications
- Cancer Genomics and Diagnostics
- Medical Imaging Techniques and Applications
- Hepatocellular Carcinoma Treatment and Prognosis
- Colorectal Cancer Surgical Treatments
- Glioma Diagnosis and Treatment
- Electrospun Nanofibers in Biomedical Applications
- Cancer, Hypoxia, and Metabolism
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Liver Disease Diagnosis and Treatment
- Appendicitis Diagnosis and Management
- Colorectal Cancer Screening and Detection
- Diverticular Disease and Complications
- Lanthanide and Transition Metal Complexes
- Radiation Dose and Imaging
- Diagnosis and treatment of tuberculosis
- Hematological disorders and diagnostics
- Gastric Cancer Management and Outcomes
- Nanoparticle-Based Drug Delivery
- Pediatric Hepatobiliary Diseases and Treatments
- Cancer Research and Treatments
- Sarcoidosis and Beryllium Toxicity Research
Moffitt Cancer Center
2020-2025
University of Arizona
2012-2017
Banner - University Medical Center Tucson
2015-2016
University Medical Center
2013
Emory University
2002-2012
Georgia Institute of Technology
2002-2003
Fort Lewis College
2001
To evaluate relative detection of pulmonary embolism (PE) with standard bolus-triggered contrast-enhanced breath-hold magnetic resonance (MR) angiography, recirculation-phase low-flip angle three-dimensional (3D) gradient-echo (GRE), and nonenhanced free-induction cardiac- respiratory-triggered true fast imaging steady-state precession (FISP) MR sequences.The study was HIPAA compliant institutional review board approved. Twenty-two patients a computed tomographic (CT) angiography diagnosis...
To determine the accuracy of unenhanced magnetic resonance (MR) imaging in detection acute appendicitis patients younger than 50 years who present to emergency department with right lower quadrant (RLQ) pain.The institutional review board approved this retrospective study 403 from August 1, 2012, July 30, 2014, and waived informed consent requirement. A cross-department strategy was instituted use MR as primary diagnostic modality aged 3-49 presented RLQ pain. All examinations were performed...
Abstract Background Soft tissue sarcomas (STS), have significant inter- and intra-tumoral heterogeneity, with poor response to standard neoadjuvant radiotherapy (RT). Achieving a favorable pathologic (FPR ≥ 95%) from RT is associated improved patient outcome. Genomic adjusted radiation dose (GARD), radiation-specific metric that quantifies the expected treatment effect as function of tumor genomics, proposed STS significantly underdosed. radiomic where habitats can delineate regions hypoxia...
263 Background: The total neoadjuvant therapy (TNT) paradigm for locally advanced rectal cancer (LARC) is evolving with intensification and de-escalation therapies. Chemoradiation (CRT) followed by consolidation chemotherapy offers the highest rate of organ preservation. Circulating tumor DNA (ctDNA) response during TNT may serve as a biomarker that allows personalization to better select candidates preservation (Watch-and-Wait, WW). Methods: We enrolled patients mismatch repair proficient...
TPS514 Background: Human epidermal growth factor receptor 2 (HER2) is overexpressed in about 15-20% of GECs and tested using immunohistochemistry and/or in-situ hybridization. Per 3 rd interim analysis KN-811 study, addition P to C/T improved overall response rate (ORR) survival (OS) patients with HER2 positive tumors. heterogeneity activation other signaling pathways ultimately leading T resistance limits its potential have a durable response. Nera an anilinoqiunoline derivative...
Multiple Myeloma represents a plasma cell disorder that can result in hallmark bony destructive change addition to other signs of myelomatous disease. Imaging often helps establishing the diagnosis and staging patient. There are several different imaging modalities provide levels insight into disease extent. We report unique case multiple myeloma where progressive nature patient's highlights strengths limitations approaches. Whole-body MRI noncontrast technique directly images bone marrow...
Purpose To investigate ferumoxytol (FMX)-enhanced MRI as a pretreatment predictor of response to liposomal irinotecan (nal-IRI) for thoracoabdominal and brain metastases in women with metastatic breast cancer (mBC). Materials Methods In this phase 1 expansion trial (ClinicalTrials.gov identifier, NCT01770353; 27 participants), 49 (19 participants; mean age, 48 years ± 11 [SD]) 19 (seven 54 8) were analyzed on MR images acquired before, 1–4 hours after, 16–24 after FMX administration....
Diffusion weighted imaging (DWI) allows for the interrogation of tissue cellularity, which is a surrogate cellular proliferation. Previous attempts to incorporate DWI into workflow 0.35 T MR-linac (MRL) have lacked quantitative accuracy. In this study, accuracy, repeatability, and geometric precision apparent diffusion coefficient (ADC) maps produced using an echo planar (EPI)-based protocol on MRL system illustrated, in vivo potential longitudinal patient demonstrated.Accuracy repeatability...
BACKGROUND: While multiple cyst features are evaluated for stratifying pancreatic intraductal papillary mucinous neoplasms (IPMN), size is an important factor that can influence treatment strategies. When magnetic resonance imaging (MRI) used to evaluate IPMNs, no universally accepted sequence provides optimal measurements. T2-weighted coronal/axial have been suggested as primary measurement sequences; however, it remains unknown how well these and maximum all-sequence diameter measurements...
Malnutrition is a common and distressing condition among pancreatic cancer patients. Fewer than quarter of patients receive medical nutrition therapy (MNT), important for improving nutritional status, weight maintenance, quality life survival. System, provider, patient level barriers limit access to MNT. We propose examine the feasibility 12-week multi-level, digital health intervention designed expand MNT Individuals with advanced starting chemotherapy (N = 80) will be 1:1 randomized or...
External beam radiotherapy (XRT) is a widely used cancer treatment, yet responses vary dramatically among patients. These differences are not accounted for in clinical practice, partly due to lack of sensitive early response biomarkers. We hypothesize that quantitative magnetic resonance imaging (MRI) measures reflecting tumor heterogeneity can provide and robust biomarker XRT response. MRI T2 mapping was performed every 72 hours following 10 Gy dose two models pancreatic propagated the hind...
Radiologic images provide a way to monitor tumor development and its response therapies in longitudinal minimally invasive fashion. However, they operate on macroscopic scale (average value per voxel) are not able capture microscopic (cell-level) phenomena. Nevertheless, examine the causes of frequent fast fluctuations tissue oxygenation, models simulating individual cells’ behavior needed. Here, we link between average data values recorded for radiologic cellular vascular architecture...