A5047269661- Advanced MRI Techniques and Applications
- Glioma Diagnosis and Treatment
- Medical Imaging Techniques and Applications
- MRI in cancer diagnosis
- Atomic and Subatomic Physics Research
- Radiomics and Machine Learning in Medical Imaging
- Brain Metastases and Treatment
- Functional Brain Connectivity Studies
- Cancer therapeutics and mechanisms
- Cardiovascular Health and Disease Prevention
- Cardiovascular Function and Risk Factors
- Nanoplatforms for cancer theranostics
- Migraine and Headache Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- CAR-T cell therapy research
- Drug Transport and Resistance Mechanisms
- Cerebral Venous Sinus Thrombosis
- Cerebrospinal fluid and hydrocephalus
- Optical Imaging and Spectroscopy Techniques
- Neurological Complications and Syndromes
- Advanced Radiotherapy Techniques
- Cancer Research and Treatments
- Advanced Neuroimaging Techniques and Applications
Moffitt Cancer Center
2019-2024
Cancer Research Center
2019
Johns Hopkins Medicine
2016-2017
Johns Hopkins University
2015-2017
Advanced Imaging Research (United States)
2015-2017
The University of Texas Southwestern Medical Center
2015-2017
Center for Neuroscience and Regenerative Medicine
2017
National Institutes of Health
2017
The University of Texas at Arlington
2015-2016
Alzheimer's disease (AD) is the leading cause of degenerative dementia in aging population. Patients with AD have alterations cerebral hemodynamic function including reduced blood flow (CBF) and metabolic rate. Therefore, improved cerebrovascular may be an attractive goal for pharmaceutical intervention AD.We wished to observe acute effects sildenafil on brain metabolism patients used several novel non-invasive MRI techniques investigate CBF, rate oxygen (CMRO2), reactivity (CVR) after a...
Hypercapnia challenge (e.g. inhalation of CO 2 ) has been used in calibrated fMRI as well the mapping vascular reactivity cerebrovascular diseases. An important assumption underlying these measurements is that a pure but does not alter neural activity. However, recent reports have suggested may suppress activity and brain metabolic rate. Therefore, goal this study to propose test gas truly “iso-metabolic,” by adding hypoxic component hypercapnic challenge, since hypoxia shown enhance...
Cerebrovascular reactivity (CVR) mapping using CO2-inhalation can provide important insight into vascular health. At present, blood-oxygenation-level-dependent (BOLD) MRI acquisition is the most commonly used CVR method due to its high sensitivity, spatial resolution, and relatively straightforward processing. However, large variations in across subjects different sessions of same subject are often observed, which cloud ability this promising measure detecting diseases or monitoring...
Abstract The vascular disrupting agent crolibulin binds to the colchicine binding site and produces anti-vascular apoptotic effects. In a multisite phase 1 clinical study of (NCT00423410), we measured treatment-induced changes in tumor perfusion water diffusivity ( ADC ) using dynamic contrast-enhanced MRI (DCE-MRI) diffusion-weighted (DW-MRI), computed correlates pharmacokinetics. 11 subjects with advanced solid tumors were imaged by at baseline 2–3 days post-crolibulin (13–24 mg/m 2 )....
Background To devise an improved blood‐oxygen‐level‐dependent (BOLD) imaging protocol for cerebrovascular reactivity (CVR) measurement that can remove a known artifact of negative values. Methods Theoretical and simulation studies were first performed to understand the biophysical mechanism CVR signals, through which BOLD sequence parameters proposed. This was achieved by equating signal intensities between cerebrospinal fluid blood, means shortening echo time (TE) sequence. Then, 10 healthy...
Purpose To investigate ferumoxytol (FMX)-enhanced MRI as a pretreatment predictor of response to liposomal irinotecan (nal-IRI) for thoracoabdominal and brain metastases in women with metastatic breast cancer (mBC). Materials Methods In this phase 1 expansion trial (ClinicalTrials.gov identifier, NCT01770353; 27 participants), 49 (19 participants; mean age, 48 years ± 11 [SD]) 19 (seven 54 8) were analyzed on MR images acquired before, 1–4 hours after, 16–24 after FMX administration....
Purpose To investigate the venous oxygenation and flow in brain, determine how they might change under challenged states. Materials Methods Eight healthy human subjects (24–37 years) were studied. T 2 ‐relaxation spin tagging (TRUST) magnetic resonance imaging (MRI) phase‐contrast MRI performed to measure blood flow, respectively, superior sagittal sinus (SSS), straight (SS), internal jugular veins (IJVs). Venous was assessed at room air (0.03%CO , 21%O ) hyperoxia (O%CO 95%O 5%N conditions....
Hemodynamic mapping using gas inhalation has received increasing interest in recent years. Cerebrovascular reactivity (CVR), which reflects the ability of brain vasculature to dilate response a vasoactive stimulus, can be measured by CO2 with continuous acquisition blood oxygen level-dependent (BOLD) magnetic resonance images. Cerebral volume (CBV) O2 inhalation. These hemodynamic methods are appealing because their absence gadolinium contrast agent, assess both baseline perfusion and...
Confounding appearance of radiographic changes in recurrent high grade glioma (HGG) patients treated with multimodality immunotherapy presents a challenge to the neuro-radiologist. A clinical need exists improve upon conventional criteria for assessment GBM on standard-of-care (SOC; T1w, T2w, FLAIR, and T1w-enhanced) MRI help distinguish treatment-related effects from true disease progression. We have investigated feasibility intensity-based segmentation tumor tissue types multiparametric...
Multispectral analysis of coregistered multiparametric magnetic resonance (MR) images provides a powerful method for tissue phenotyping and segmentation. Acquisition sufficiently varied set multicontrast MR parameter maps to objectively define multiple normal pathologic types can require long scan times. Accelerated MRI on clinical scanners with multichannel receivers exploits techniques such as parallel imaging, while accelerated preclinical scanning must rely alternate approaches. In this...
Phagocytosis of ferumoxytol (FMX) by tumor-associated macrophages (TAMs) results in intracellular compartmentation, which has opposing effects on longitudinal (R 1 ) and transverse 2 * relaxivity FMX. Pixelwise mismatch between apparent concentration (FMX c computed from post-FMX R maps can be exploited to identify pixels with high concentrations phagocytosed (compartmentalized) Here we show MRI, acquired 24 h post-FMX, measured terms compartmentation index (CI) greater than hypothesized...
R * 2 and the apparent concentration of FMX in tumor (FMX C ) are considered biomarkers liposomal irinotecan (nal-IRI) drug uptake into that lesion, which turn would determine response to nal-IRI. Historically, quantification had been implemented by using a calibration phantom acquiring patient scans both pre-FMX post-FMX. Here we have demonstrated pre-treatment FMX-enhanced MRI companion biomarker nal-IRI mBC patients can be computed from single16-24 h post-FMX scan without need for...
Abstract We report domain knowledge-based rules for assigning voxels in brain multiparametric MRI (mpMRI) to distinct tissuetypes based on their appearance Apparent Diffusion Coefficient of water (ADC) maps, T1-weighted unenhanced and contrast-enhanced, T2-weighted, Fluid-Attenuated Inversion Recovery images. The development dataset comprised mpMRI 18 participants with preoperative high-grade glioma (HGG), recurrent HGG (rHGG), metastases. External validation was performed 235 the BraTS 2020...
Abstract INTRODUCTION Immunotherapy with engineered CAR T cells is a promising new therapy for glioblastoma, which predictive and prognostic biomarkers are needed to inform effective intervention. Recently, our group analyzed standard-of-care (SOC) MRI images of long-term short-term glioblastoma survivors identified six intratumoral “habitats” “Habitat 6” was correlated survival at diagnosis in high-grade glioma. Based on the characteristics 6”, viz. high enhancement edema, we hypothesized...