A5089533327- Diabetes Treatment and Management
- Endoplasmic Reticulum Stress and Disease
- Pancreatic function and diabetes
- Liver Disease Diagnosis and Treatment
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Bone health and osteoporosis research
- Diabetes Management and Research
- Metabolism, Diabetes, and Cancer
- Lymphatic Disorders and Treatments
- Adipokines, Inflammation, and Metabolic Diseases
- Adipose Tissue and Metabolism
- Gout, Hyperuricemia, Uric Acid
- Atherosclerosis and Cardiovascular Diseases
- Nutrition and Health in Aging
- Body Composition Measurement Techniques
- Genetic and Kidney Cyst Diseases
- Diet, Metabolism, and Disease
- Lymphatic System and Diseases
- Neuropeptides and Animal Physiology
- Vascular Malformations and Hemangiomas
- Neurological and metabolic disorders
- Inflammasome and immune disorders
- Autophagy in Disease and Therapy
- RNA Research and Splicing
- Hereditary Neurological Disorders
National Defense Medical Center
2015-2025
Tri-Service General Hospital
2015-2025
Type 2 diabetes mellitus (T2DM) is an independent risk factor of knee osteoarthritis (KOA). This study was mainly based on data from the Taiwan National Health Insurance Database. Using big analysis, we showed that glucagon-like peptide-1 receptor agonist (GLP-1RA) treatment helpful for patients with T2DM who have a lower KOA or total replacement (TKR). A 35,762 were included in this study. We divided these into 988 without and 372 received GLP-1RA those did not receive treatment. The...
Increasing evidence suggests that high glucose (HG) causes abnormalities in endothelial and vascular smooth muscle cell function (VSMC) contributes to atherosclerosis. Receptor for advanced glycation end-products (RAGE) has been linked the pathogenesis of both macrovascular microvascular complications diabetes. Cilostazol is used treat diabetic vasculopathy by ameliorating HG-induced dysfunction.In this study, we investigated whether cilostazol suppression VSMC dysfunction through RAGE...
Recent evidence has suggested that synovial inflammation and macrophage polarization were involved in the pathogenesis of osteoarthritis (OA). Additionally, high-molecular-weight hyaluronic acid (HMW-HA) was often used clinically to treat OA. GRP78, an endoplasmic reticulum (ER) stress chaperone, contribute hyperplasia cells However, it still unclear whether HMW-HA affected through GRP78. Therefore, we aimed identify effect primary investigate role GRP78 signaling. We IL-1β synoviocytes...
Patients with diabetes have a relatively high risk of fracture due to osteoporosis. However, the osteoporosis associated use oral hypoglycemic drugs and dipeptidyl peptidase-4 inhibitor (DPP-4i) by patients is unclear. This study aimed explore effect DPP-4i on in Taiwanese type 2 mellitus (T2DM).This enrolled 6339 (DPP-4i group) 25 356 without (non-DPP-4i group). They were matched 1:4 propensity score matching, using confounding variables including sex, age, comorbidities, medication, index...
Endoplasmic reticulum (ER) stress has emerged as a key player in insulin resistance (IR) progression skeletal muscle. Recent reports revealed that ER stress-induced the expression of protein disulfide isomerase family member 4 (PDIA4), which may be involved IR-related diseases. A previous study showed metformin modulated IR. However, it remained unclear whether alleviated IR by regulating PDIA4 muscle.Herein, we used palmitate-induced C2C12 cells and high-fat diet-induced mouse model to...
Abstract Aims/Introduction Studies suggest that salivary proteins can be used as potential non‐invasive markers for clinical diagnosis and screening diabetes. Previous reports showed plasma alpha 2‐macroglobulin (A2 MG ) levels were higher in diabetic patients, especially with complications. We investigated the relationship between A2 values characteristics patients type 2 Materials Methods A total of 91 adults recruited from our outpatient clinics. The study patients' collected general...
Abstract Increasing evidence supporting a causal link between obesity and endoplasmic reticulum (ER) stress in adipose tissue is being reported. Protein disulfide isomerase 4 (PDIA4) novel ER chaperone involved the pancreatic β‐cells pathogenesis diabetes. However, role of PDIA4 progression remains poorly understood. To assess relationship PDIA4, adiponectin, metformin, we used palmitate‐induced inflammation hypertrophic adipocytes high‐fat diet‐induced mouse model. Our results revealed that...
Morbid obesity is related to chronic inflammation and many metabolic complications. Interleukin (IL)-6 plays a pivotal pathophysiological role in obesity, IL-6 trans-signaling through the soluble receptor (sIL-6R) has major proinflammatory effect. The aim of this study was investigate association between sIL-6R, adipocyte size, insulin resistance morbidly obese individuals.We measured concentrations high-sensitivity C-reactive protein, lipid parameters estimated homeostasis model assessment...
Aims: Variants of the glucokinase regulator (GCKR) gene are associated with metabolic syndrome (MetS). The present study explored association between a common variant this and MetS its related traits in Taiwanese adolescents. Methods: frequency features were compared subjects (n = 962; 468 male, 494 female) different genotypes or alleles GCKR rs780094 single-nucleotide polymorphism. Logistic regression analysis was carried out to explore interdependence traits. Results: Low high-density...
Cardiovascular events such as myocarditis following mRNA COVID-19 vaccination are increasing. We present a 67-year-old postmenopausal woman with Takotsubo Syndrome and Graves' disease after vaccination. She developed chest pain shortness of breath one week An electrocardiogram revealed ST elevation in the precordial leads. Coronary angiography absence obstructive coronary artery disease, left ventriculography showed typical feature apical ballooning. Laboratory workup free T4 thyrotropin...
Chronic inflammation, a hallmark of gout, is implicated in the pathogenesis atherosclerosis. Thus, theory, gout can be expected to increase risk acute myocardial infarction (AMI). Yet, results from several epidemiological studies have been inconclusive. A retrospective cohort study was conducted using National Health Insurance Research Database Taiwan dated 2000 2013. The comprised 3581 patients with (the cohort) and 14,324 without non-gout cohort). primary outcome incidence AMI. To estimate...
Papillary thyroid cancer (PTC) is the most common endocrine malignancy with a fast-growing incidence in recent decades. HOTAIR as long non-coding RNA has been shown to be highly expressed papillary tissues only limited understanding of its functional roles and downstream regulatory mechanisms cells.We applied three cell lines (MDA-T32, MDA-T41 K1) investigate phenotypic influence after gain or loss HOTAIR. The Cancer Genome Atlas (TCGA) database were utilised select candidate genes possibly...
This study investigated the effect of a combination glucagon-like peptide-1 receptor agonist (GLP-1 RA) and basal insulin (BI) in poorly controlled type 2 diabetes mellitus previously treated with premixed insulin. The possible therapeutic benefit subject is mainly hoped to provide direction for optimizing treatment options reduce risk hypoglycemia weight gain. A single-arm, open-label was conducted. antidiabetic regimen switched GLP-1 RA plus BI replace previous subjects. After 3 months...
Diabetes with co-existing bone fragility or osteoporosis is common in elderly patients, whereas frequently underestimated. We conducted dual-energy x-ray absorptiometry (DXA) 7-site skinfold (SF) and dominant hand grip strength measurements among patients type 2 diabetes (T2DM) to assess their gender-specific associations. A total of 103 T2DM (60 females 43 males), aged between 50 80 years (median 68.0 years) were enrolled 45 non-DM also included compare females. Our results revealed was...
Dedifferentiated fat cells (DFATs) are highly homogeneous and multipotent compared with adipose-derived stromal (SCs). Infrapatellar pad (IFP)-SCs have advanced chondrogenic potency; however, whether IFP-DFATs could serve as better cell material remains unclear. Here, we aimed to examine the influence of age body mass index (BMI) on features IFPs IFP-derived (IFP-SCs IFP-DFATs) exploration clinical utilization IFP-DFATs.We collected isolation paired IFP-SCs from individuals aged 65 years...
Chronic kidney disease (CKD) is associated with increased cardiovascular mortality, and vascular smooth muscle cell (VSMC) dysfunction plays a pivotal role in uremic atherosclerosis. Axl signaling involved injury highly expressed VSMCs. Recent reports have shown that cilostazol, phosphodiesterase type 3 inhibitor (PDE3), can regulate various stages of the atherosclerotic process. However, cilostazol vasculopathy remains unclear. This study aimed to identify effect VSMCs experimental CKD...
<b>Objective:</b> Hematological parameters play a significant role in metabolic syndrome (MetS) and its development the elderly, but association different ability of each parameter to predict MetS have not been investigated very old populations. <b>Subjects Methods:</b> This cross-sectional longitudinal study included 18,907 participants aged over 65 years followed up until with mean duration 4 from entry date. was diagnosed according latest harmonized criteria modification for waist...
Abstract Background: Diabetic neuropathy (DN) is one of the common chronic complications, leading to limb disability and increased risks hospitalization mortality. Traditional Chinese medicine (TCM) has been commonly applied in Taiwan as an adjunctive treatment ameliorate diabetes-associated including neuropathy. Aim: We aimed investigate whether clinical DN combined with TCM can reduce associated mortality using National Health Insurance Research Database (NHIRD) Taiwan. Methods: selected...
Studies have confirmed that osteoporosis has been considered as one of the complications diabetes, and health hazards to patients are more obvious. This study is mainly based on Taiwan National Health Insurance Database (TNHID). Through analysis TNHID, it shown combined treatment traditional Chinese medicine (TCM) in diabetes with (T2DOP) lower related risks.
Cervical chyloma is a not uncommon complication after neck surgery, especially following diagnostic excision of supraclavicular lymph nodes. Conservative treatment remains the standard approach but inevitably distressful. We describe case 60-year-old Asian woman who was diagnosed as having adenocarcinoma lung with cervical and node involvement. She developed persistent chyle leak excisional biopsy nodes proved refractory to all management. Subsequent gefitinib therapy led rapid resolution...
Cervical chyloma is a not uncommon complication after neck surgery, especially following diagnostic excision of supraclavicular lymph nodes. Conservative treatment remains the standard approach but inevitably distressful. We describe case 60-year-old Asian woman who was diagnosed as having adenocarcinoma lung with cervical and node involvement. She developed persistent chyle leak excisional biopsy nodes proved refractory to all management. Subsequent gefitinib therapy led rapid resolution...
Sir, A 38-year-old woman without previous medical history initially presented menstrual abnormality for 2 months. Later on, elated mood increased goal-direct behavior, decreased need sleep, grandiose delusion, poor concentration, hypertalkativeness, and psychomotor agitation were followed, which required urgent hospitalization. In addition, physical examination showed hirsutism, buffalo hump, peripheral edema, acne. Laboratory tests revealed hypokalemia, metabolic alkalosis, elevated serum...