Zulema Rodriguez-Hernandez

ORCID: 0000-0003-0720-384X
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About
Contact & Profiles
Research Areas
  • Heavy Metal Exposure and Toxicity
  • Trace Elements in Health
  • Genetic Associations and Epidemiology
  • Selenium in Biological Systems
  • Bone health and osteoporosis research
  • Metabolomics and Mass Spectrometry Studies
  • Gene expression and cancer classification
  • Bioinformatics and Genomic Networks
  • Cancer-related molecular mechanisms research
  • MicroRNA in disease regulation
  • Epigenetics and DNA Methylation
  • Arsenic contamination and mitigation
  • Acute Lymphoblastic Leukemia research
  • RNA Research and Splicing
  • Diet and metabolism studies
  • Heavy metals in environment
  • Health, Environment, Cognitive Aging
  • RNA modifications and cancer
  • Birth, Development, and Health

Instituto de Salud Carlos III
2021-2025

Universitat Politècnica de València
2022-2025

University of Freiburg
2024-2025

University Medical Center Freiburg
2024

Centro Nacional de Epidemiología
2022

To assess whether the role of selenium on pre-diabetes is differential by age, given comorbidities and decreased β-cell function in older adults. We evaluated cross-sectional association blood with homeostatic model assessment for insulin resistance (HOMA-IR) (HOMA-β) middle-aged (Aragon Workers Health Study [AWHS], N = 1186), (Seniors ENRICA [Study Nutrition Cardiovascular Risk Spain]-2 [SEN-2], 915) diabetes-free A subsample participants from AWHS (N 571) SEN-2 603) had glucose repeated...

10.1038/s41387-025-00361-2 article EN cc-by-nc-nd Nutrition and Diabetes 2025-02-13

Limited studies have evaluated the joint influence of redox-related metals and genetic variation on metabolic pathways. We analyzed association 11 with patterns, interacting role candidate variants, in 1145 participants from Hortega Study, a population-based sample Spain.Urine antimony (Sb), arsenic, barium (Ba), cadmium (Cd), chromium (Cr), cobalt (Co), molybdenum (Mo) vanadium (V), plasma copper (Cu), selenium (Se) zinc (Zn) were measured by ICP-MS AAS, respectively. summarized 54...

10.1016/j.redox.2022.102314 article EN cc-by-nc-nd Redox Biology 2022-04-14

Abstract The statistical analysis of omics data poses a great computational challenge given their ultra–high-dimensional nature and frequent between-features correlation. In this work, we extended the iterative sure independence screening (ISIS) algorithm by pairing ISIS with elastic-net (Enet) 2 versions adaptive (adaptive (AEnet) multistep (MSAEnet)) to efficiently improve feature selection effect estimation in research. We subsequently used genome-wide human blood DNA methylation from...

10.1093/aje/kwae006 article EN American Journal of Epidemiology 2024-02-20

Abstract Summary This article introduces the metaGWASmanager, which streamlines genome-wide association studies within large-scale meta-analysis consortia. It is a toolbox for both central consortium analysis group and participating to generate homogeneous phenotypes, minimize unwanted variability from inconsistent methodologies, ensure high-quality results, implement time-efficient quality control workflows. The features plug-in-based approach customization of testing. Results...

10.1093/bioinformatics/btae294 article EN cc-by Bioinformatics 2024-04-30

Abstract Summary This paper introduces the metaGWASmanager, which streamlines genome-wide association studies within large-scale meta-analysis consortia. It is a toolbox for both central consortium analysis group and participating to generate homogeneous phenotypes, minimize variance from inconsistent methodologies, ensure high-quality results, implement time-efficient quality control workflows. The features plug-in-based approach customization. Results metaGWASmanager has been successfully...

10.1101/2024.03.12.584556 preprint EN bioRxiv (Cold Spring Harbor Laboratory) 2024-03-14

Background: Identifying potencial determinants of serum selenoproteins and selenometabolites can help understanding selenium-related metabolism health consequences. We evaluated the cross-sectional association between environmental factors total concentration composition in Aragon Workers Health Study (AWHS), a participating cohort SelenOmics project. Materials methods. Serum (glutathione peroxidase [GPx], selenoprotein P [SeP], selenoalbumin [SeAlb]), (Se-metabolites) selenium urine metals...

10.1289/isee.2022.p-0880 article EN ISEE Conference Abstracts 2022-09-18

Background and aim: The bone remodeling process may be influenced by metabolic factors. We evaluated the cross-sectional association of patterns with reduced mineral density (BMD) prospective incident osteoporosis-related fractures. Since copper, selenium, zinc, arsenic, antimony, cadmium cobalt have been related to oxidative stress biomarkers in our study population, redox balance play a key role metabolism, we also assessed potential differential associations subgroups defined metals above...

10.1289/isee.2022.p-0062 article EN ISEE Conference Abstracts 2022-09-18
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