A5051375042- Mitochondrial Function and Pathology
- Chemotherapy-induced cardiotoxicity and mitigation
- ATP Synthase and ATPases Research
- Calcium signaling and nucleotide metabolism
- Angiogenesis and VEGF in Cancer
- Cardiac Arrhythmias and Treatments
- Peripheral Artery Disease Management
- Cerebrovascular and Carotid Artery Diseases
- Parkinson's Disease Mechanisms and Treatments
- Adipose Tissue and Metabolism
- Atrial Fibrillation Management and Outcomes
- Inflammatory Biomarkers in Disease Prognosis
- Venous Thromboembolism Diagnosis and Management
- Lipid metabolism and biosynthesis
- Cardiac, Anesthesia and Surgical Outcomes
- Cell Adhesion Molecules Research
- Heart Failure Treatment and Management
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Cardiovascular Function and Risk Factors
- Autophagy in Disease and Therapy
- Protease and Inhibitor Mechanisms
- Ubiquitin and proteasome pathways
- Coenzyme Q10 studies and effects
- Alcohol Consumption and Health Effects
- Acute Myocardial Infarction Research
Guangdong Provincial People's Hospital
2022-2025
Guangdong Academy of Medical Sciences
2022-2025
Southern Medical University
2023-2025
Second Hospital of Hebei Medical University
2024
Hebei Medical University
2024
South China University of Technology
2022
Autophagy dysregulation is known to be a mechanism of doxorubicin (DOX)-induced cardiotoxicity (DIC). Mitochondrial-Endoplasmic Reticulum Contacts (MERCs) are where autophagy initiates and autophagosomes form. However, the role MERCs in DIC remains elusive. FUNDC1 tethering protein MERCs. We aim investigate effect DOX on cardiomyocytes explore whether it involved dysregulated DIC.
Aim: In patients with ST-segment elevation myocardial infarction (STEMI) undergoing percutaneous coronary intervention (PCI), a low serum albumin-to-creatinine ratio (sACR) is associated elevated risk of poor short- and long-term outcomes. However, the relationship between sACR pulmonary infection during hospitalization in STEMI PCI remains unclear.
Background Atrial fibrillation (AF) is the most common cardiac arrhythmia, significantly increasing risk of death and stroke. The left atrial appendage (LAA) plays a crucial role in development AF. Reduced emptying velocity (LAAEV) an important indicator nonvalvular AF, associated with thrombosis recurrence after catheter ablation. This study aims to identify factors influencing LAAEV construct predictive model for AF patients. Methods retrospective cohort included 1,048 patients...
It is unclear whether admission-blood-glucose-to-albumin ratio (AAR) predicts adverse clinical outcomes in patients with ST-segment elevation myocardial infarction (STEMI) who are treated percutaneous coronary intervention (PCI). Here, we performed a observational study to explore the predictive value of AAR on outcomes.Patients diagnosed STEMI underwent PCI between January 2010 and February 2020 were enrolled study. The classified into three groups according tertile. primary outcome was...
Peripheral arterial disease (PAD) leads to tissue ischemia in the extremities. Enhanced vascular permeability plays a critical role targeted delivery of drugs for effective therapeutic angiogenesis and resultant blood perfusion recovery. However, optimal tracers evaluating this process PAD patients are lacking. At time, we employed novel vivo albumin-labeling tracer dual function, termed as 18F-NEB, assess well by positron emission tomography (PET).After successful establishment mouse...
Background: Peripheral arterial disease (PAD) can severely compromise limb vitality and function. Angiogenesis plays an important role in healing of ischemic lesions. Radiolabeled RGD (Arg-Gly-Asp) peptides specifically targeting αvβ3 integrin are promising tracers for imaging angiogenesis. In this study, we investigated the application a one-step labeled evaluation angiogenesis therapy response mouse model hindlimb ischemia (HI) by positron emission tomography (PET). Methods: HI was induced...