A5019207894- Autoimmune Neurological Disorders and Treatments
- Peripheral Neuropathies and Disorders
- Multiple Sclerosis Research Studies
- Cytomegalovirus and herpesvirus research
- Genetics and Neurodevelopmental Disorders
- Nerve injury and regeneration
- Myasthenia Gravis and Thymoma
- RNA regulation and disease
- Acute Ischemic Stroke Management
- Cancer-related molecular mechanisms research
- Intracerebral and Subarachnoid Hemorrhage Research
- Alzheimer's disease research and treatments
- Infectious Encephalopathies and Encephalitis
- Herpesvirus Infections and Treatments
- interferon and immune responses
- MicroRNA in disease regulation
- Viral Infections and Vectors
- Hereditary Neurological Disorders
- Genetic Neurodegenerative Diseases
- Neurosurgical Procedures and Complications
- Cancer Research and Treatments
- Protein Tyrosine Phosphatases
- Neuroinflammation and Neurodegeneration Mechanisms
- Glioma Diagnosis and Treatment
- Cancer Cells and Metastasis
Shandong Provincial Hospital
2016-2025
Shandong First Medical University
2020-2025
Shandong University
2015-2024
Shougang (China)
2017
Fujian Provincial Hospital
2010
Huazhong University of Science and Technology
2004-2007
Purpose To explore the clinical features, diagnosis, treatment, and prognosis of anthrax meningoencephalitis. Methods The data two cases meningoencephalitis were summarized relevant literature was reviewed. Results Both patients, who farmers, had cutaneous lesions prior to onset manifestations included fever (2/2), headache stupor meningeal signs lymph node enlargement (2/2). CSF analysis showed erythrocytes, increased neutrophils, low glucose levels high protein levels. cytology revealed...
Background: Abnormalities within the insular cortex of salience and thalamus hyperarousal network have been increasingly reported in healthy participants with insomnia symptoms by recent resting-state functional magnetic resonance imaging (rsfMRI) studies. However, little is known about changes interaction between bilateral cerebral hemispheres symptoms. Methods: In a randomized trial, 27 age-, gender-, educational level-matched without underwent rsfMRI. Voxel-mirrored homotopic connectivity...
Objective This study aimed to determine the clinical characteristics and evaluate efficacy of immunotherapy long-term prognosis severe autoimmune encephalitis (AE) in China. Methods Clinical features, laboratory or radiological findings, treatment outcomes 60 patients with AE from January 1, 2014, December 31, 2020, were collected. Continuous variables compared using t -test nonparametric Mann–Whitney U test, as appropriate. Univariate multivariable logistic regression analyses performed...
The precise associations between stroke and carotid plaques dyslipidemia are unclear. This population-based study aimed to examine the relationship in a high-stroke-risk population.Ultrasonography of left right arteries was conducted 22,222 participants second screening survey individuals with high risk. Subjects were divided into two groups according presence or absence plaques. Blood TC (total cholesterol), TG triglycerides), LDL-C (low-density lipoprotein cholesterol) levels...
Ofatumumab presents a potentially promising alternative to current second-line immunotherapy for refractory anti-N-methyl-D-aspartate receptor autoimmune encephalitis (NMDAR-AE). We aimed evaluate the efficacy and safety of ofatumumab as novel NMDAR-AE. This prospective, multicenter, nested cohort study compared patients with NMDAR-AE from CHina Autoimmune encephalitiS outcomE registry (CHASE) recruited between October 2011 February 2024, treated without ofatumumab. The primary outcome was...
Background and Purpose Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis is the most common type of autoimmune encephalitis.This study aimed to explore possible factors affecting response first-line treatments in patients with anti-NMDAR encephalitis. MethodsWe enrolled 29 who were diagnosed as between January 1, 2015, June 30, 2018.They divided into remission nonremission groups according their treatments.The demographics, clinical manifestations, main ancillary examinations,...
Objective To compare the efficacy and safety of different-course corticosteroids plus mycophenolate mofetil (MMF) as maintenance therapy in autoimmune encephalitis (AE) with neuronal surface antibodies (NSAbs) without tumor explore optimal course corticosteroids. Methods Fifty-five patients definite AE were enrolled consecutively between June 2015 November 2020 retrospectively divided three groups according to treatment corticosteroid, i.e., a group 3-6 months (Group 3-6mo), 6-12 6-12mo),...
Oligodendrocyte precursor cells are present in the adult central nervous system, and their impaired ability to differentiate into myelinating oligodendrocytes can lead demyelination patients with multiple sclerosis, accompanied by neurological deficits cognitive impairment. Exosomes, small vesicles released cells, known facilitate intercellular communication carrying bioactive molecules. In this study, we utilized exosomes derived from human umbilical cord mesenchymal stem (HUMSCs-Exos). We...
Previously, we have reported a cohort of Japanese encephalitis (JE) patients with Guillain–Barré syndrome. However, the evidence linking virus (JEV) infection and peripheral nerve injury (PNI) remains limited, especially epidemiology, clinical presentation, diagnosis, treatment, outcome significantly differ from traditional JE. We performed retrospective multicenter study 1626 JE recorded in surveillance system Chinese Center for Disease Control Prevention, spanning years 2016 to 2020. Cases...
Multiple sclerosis (MS) was defined as a rare disease in China due to its low prevalence. For long time, interferon β the only approved disease-modifying therapy (DMT). Since first oral DMT 2018, approval accelerated, and seven DMTs were within 5 years. With an increasing number of being prescribed clinical practice, it is necessary discuss standardized MS treatment algorithms depending on activity availability. In this review paper, more than 20 Chinese experts have reviewed therapeutic...
Abstract Introduction Considering the program of screening for risk factors stroke in Eastern China, aim this study was to compare distribution differences among high‐risk population living urban and rural areas. Methods A total 231,289 residents were screened basic information collected. Risk compared between groups. Results 117,776 from areas 113,513 included analysis. The prevalence hypertension much higher (73.3%) than that (64.1%). Dyslipidemia (48.9% vs. 26.9%), sport lack (46.6%...
Objective This retrospective observational study primarily aimed to analyse the clinical characteristics of patients with neuronal surface antibody-mediated autoimmune encephalitis (AE) in China and report their prognosis after immunotherapy. Methods Clinical characteristics, laboratory or imaging examinations, treatment outcomes 103 diagnosed AE between 1 September 2014 31 December 2020 were collected. Univariate multivariate logistic regression analyses performed determine predictors poor...
To investigate the association between serum circulating 25-hydroxyvitamin D [25(OH) D] concentrations and exacerbation risk in Chinese patients with relapsing-remitting multiple sclerosis (RR-MS).