A5103123803- Spine and Intervertebral Disc Pathology
- Spinal Cord Injury Research
- Spinal Fractures and Fixation Techniques
- Nerve Injury and Rehabilitation
- Platelet Disorders and Treatments
- Cervical and Thoracic Myelopathy
- Peripheral Nerve Disorders
- Nerve injury and regeneration
- CAR-T cell therapy research
- Anesthesia and Pain Management
- Pelvic and Acetabular Injuries
- Blood groups and transfusion
- Cerebral Palsy and Movement Disorders
- Urinary Bladder and Prostate Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Endoplasmic Reticulum Stress and Disease
- Pregnancy-related medical research
- Cancer-related gene regulation
- Eosinophilic Disorders and Syndromes
- RNA modifications and cancer
- Spinal Hematomas and Complications
- Neurogenesis and neuroplasticity mechanisms
- Fungal Biology and Applications
- Antifungal resistance and susceptibility
- Hemophilia Treatment and Research
Shandong University
2025
Nanjing Medical University
2014-2024
Jiangsu Province Hospital
2014-2024
Indiana University – Purdue University Indianapolis
2022
Indiana University School of Medicine
2022
Neurological Surgery
2022
Tianjin First Center Hospital
2013-2022
Tianjin Medical University
2013-2022
National Natural Science Foundation of China
2018-2022
Nankai University
2021-2022
We previously demonstrated that FK506, a generally applied immunosuppressant in organ transplantation, could promote peripheral nerve regeneration through reducing scar formation. However, little is known about how FK506 reduces Herein we investigated the influence of on fibroblast proliferation and its correlation with formation after sciatic injury rats, further explored effect apoptosis vitro. Masson staining immunohistochemistry revealed area number anastomosis nerve-injured rats were...
Computer-navigated pedicle screw insertion is applied to the thoracic and lumbar spine attain high accuracy a low rate of screw-related complications. However, some in vivo vitro studies have shown that no advantages are gained with use navigation techniques compared conventional techniques. Additionally, inconsistent conclusions been drawn various due different population characteristics methods used assess placement. Moreover, it not clear whether decreases incidence Therefore, this study...
JOURNAL/nrgr/04.03/01300535-202411000-00030/figure1/v/2024-04-10T160327Z/r/image-tiff The inflammatory microenvironment and neurotoxicity can hinder neuronal regeneration functional recovery after spinal cord injury. Ruxolitinib, a JAK-STAT inhibitor, exhibits effectiveness in autoimmune diseases, arthritis, managing cytokine storms. Although studies have shown the neuroprotective potential of ruxolitinib neurological trauma, exact mechanism by which it enhances injury, particularly its...
Background/Aims: Epidural fibrosis, a common complication after laminectomy, has been demonstrated to be closely associated with poor surgical outcomes. Previous studies showed that taurine had remarkable anti-fibrotic effects on lung and liver fibrosis. We performed this study investigate the of in rat models epidural fibrosis laminectomy explore potential molecular mechanism. Methods: Laminectomy was each establish model. After treatment, Masson's trichrome immunohistochemistry staining...
Abstract The present research focused on identifying necroptosis‐related differentially expressed genes (NRDEGs) in spinal cord injury (SCI) to highlight potential therapeutic and prognostic target clinical SCI. Three SCI‐related datasets were downloaded, including GSE151371, GSE5296 GSE47681. MSigDB KEGG searched for (NRGs). Differentially (DEGs) NRGs intersected obtain NRDEGs. MCC algorithm was employed select the first 10 as hub genes. A protein–protein interaction (PPI) network related...
Resveratrol inhibits the initiation, promotion and progression of tumors, however, mechanism by which resveratrol proliferation human chronic myeloid leukemia K562 cell line remains unclear. The present study was conducted to investigate effect on activation phosphatidylinositide 3-kinase (PI3K)/protein kinase B (Akt)/mammalian target rapamycin (mTOR) signaling cascade in cells. showed significant cytotoxic effects induced apoptosis cells a dose- time-dependent manner. In addition,...
We present a novel method for quantifying femoral orientation angles using thigh-mounted inertial measurement unit (IMU). The IMU-derived reproduce gold-standard motion capture to within mean (standard deviation) differences of 0.1 (1.1) degrees on cadaveric specimens during clinical procedures used the diagnosis Femoroacetabular Impingement (FAI). method, which assumes stationary pelvis, is easy use, inexpensive, and provides femur trajectory data in addition range measures. These...
Antibiotic pollution, particularly via tetracycline (TC), poses significant environmental risks due to its recalcitrance and potential induce antibiotic resistance. This study employed density functional theory (DFT) transition state (TST) investigate TC degradation by hydroxyl radicals (·OH), focusing on hydrogen atom transfer (HAT) radical adduct formation (RAF) pathways. Geometry optimizations vibrational analysis validated stationary points, while intrinsic reaction coordinate (IRC)...
Pseudotumor is an uncommon but severe complication in patients with hemophilia. To our knowledge, although China has large population of persons hemophilia, there rare information on the incidence, clinical feature, image finding, and management pseudotumor among Chinese patients. This study aimed at improving knowledge diagnosis hemophiliac pseudotumor. In this retrospective study, medical records 1248 hemophilia diagnosed between January 1983 October 2004 hospital were reviewed. The...
Objective To study the main molecular mechanisms responsible for itraconazole resistance in clinical isolates of Candida krusei. Methods The 14α-demethylases encoded by ERG11 gene 16 C.krusei were amplified polymerase chain reaction (PCR), and their nucleotide sequences determined to detect point mutations. Meanwhile, efflux transporters (ABC1 ABC2) genes quantitative real-time reverse transcription (qRT-PCR) expression itraconazole-resistant (R), itraconazole-susceptible dose dependent...
Anterior cervical surgery is commonly used for vertebral body lesions. However, the structure of blood vessels and nerve tissues along route anterior complex. We aimed to measure data longus colli, sympathetic trunk (CST) ganglia in Chinese cadaver specimens. A total 32 adult cadavers were studied. delineated surgical anatomy CST. The superior inferior/cervicothoracic consistently appeared. middle ganglion was observed 28.1% specimens there 2 cases unilateral double ganglia. inferior 25.0%...
Neural Regeneration Research: December 2015 - Volume 10 Issue 12 p 1953-1975 doi: 10.4103/1673-5374.172314
Hemophilia A (HA) is a common X-linked recessive bleeding disease caused by mutations in FVIII gene. The identification of mutation HA subjects can lead to more accurate diagnosis and contribute the genetic counseling/prenatal diagnosis.Our objective identify defects 148 unrelated Chinese analyze potential consequence novel mutations.FVIII: C was assayed using one-stage method, inhibitor tested Bethesda method. Intron 22 1 inversions were identified PCR technique. Non-inversion gene direct...
The persistence or recurrence of minimal residual disease (MRD) after chemotherapy predicts relapse B-cell acute lymphoblastic leukemia (B-ALL). CD19-directed chimeric antigen receptor T (CD19 CAR-T) cells have shown promising responses in B-ALL. However, their role chemotherapy-refractory MRD-positive B-ALL remains unclear. Here we aimed to assess the effectiveness and safety CD19 CAR-T patients. From January 2018, a total 14 patients received one more infusions autogenous cells. Among...
A sciatic nerve transection and repair model was established in Sprague-Dawley rats by transecting the tendon of obturator internus muscle greater foramen suturing with nylon sutures. The models were treated tacrolimus gavage (4 mg/kg per day) for 0, 2, 4 6 weeks. Specimens harvested at weeks intragastric administration. Masson staining revealed that collagen fiber content scar area anastomosis injury significantly reduced after Hematoxylin-eosin showed increased myelinated density, average...
Osteoporotic vertebral compression fracture (OVCF) has become a major public health issue that becomes more pressing with increasing global aging. Percutaneous kyphoplasty (PKP) is an effective treatment for OVCF. Robot-assisted PKP been utilized in recent years to improve accuracy and reduce complications. However, the effectiveness of robot-assisted multi-segmental OVCF yet be proved. This study was designed compare efficacy conventional fluoroscopy-assisted PKP. A total 30 cases between...
Idiopathic thrombocytopenic purpura (ITP) is an acquired organ-specific autoimmune hemorrhagic disease with many immune dysfunctions. Cytotoxic T lymphocyte antigen 4 (CTLA-4) a T-lymphocyte surface molecule that can down modulate and terminate responses. Recently, several studies have confirmed some polymorphisms of this gene influence its expression level, therefore speculating they might be associated diseases. In order to investigate the role CTLA-4 in ITP, we investigated -318 CT60 186...
We investigated the relationship between expression of IFN-γ, IL-4, Foxp3 and perforin gene methylation status their promoters in immune thrombocytopenic purpura (ITP) patients. Gene DNA were determined by quantitative PCR bisulfite genomic sequencing, respectively. The IFN-γ was higher, while IL-4 notably lower ITP patients when compared with controls. Most importantly, Th1/Th2 (IFN-γ/IL-4) remarkably higher patients, showing that mainly Th1 polarization response. Although rate CpGs located...
Background/Aims: Hypertrophic scars (HS) formation results from reduced apoptosis and increased proliferation of fibroblasts. Therefore, fibroblasts is a key target for the development novel therapeutic strategies HS. Previous reports demonstrated that FK506 could attenuate scar in vivo also induce endoplasmic reticulum stress (ER stress). However, effects on ER stress-mediated remain unclear. Methods: Rat skin were used study. Cell viability was examined using cell counting Kit-8. Apoptosis...
An anatomic study of extradural spinal root in 9 embalmed cadavers.To ascertain the anatomical parameters and to demonstrate feasibility anastomoses without opening dura mater.Intradural anastomosis has made breakthrough progress treating neurogenic bladder cord injury. However, because complex surgical procedures extensive bony destruction, its clinical use is not widely promoted.Nine formalin-fixed cadavers were used. The distance between nerve outlet ganglion center, neighboring...