A5059409569- Retinopathy of Prematurity Studies
- Neonatal Respiratory Health Research
- Ophthalmology and Visual Impairment Studies
- Neonatal and fetal brain pathology
- Visual perception and processing mechanisms
- Neonatal Health and Biochemistry
- Intraocular Surgery and Lenses
- Preterm Birth and Chorioamnionitis
- Retinal Diseases and Treatments
- Glaucoma and retinal disorders
- Corneal surgery and disorders
- Ophthalmology and Visual Health Research
- Retinal Imaging and Analysis
- Dental Education, Practice, Research
- Photoreceptor and optogenetics research
- Infant Development and Preterm Care
- Tactile and Sensory Interactions
- Cardiovascular Conditions and Treatments
- Retinal Development and Disorders
- Optical Imaging and Spectroscopy Techniques
- Diversity and Career in Medicine
- Ocular Disorders and Treatments
- Ophthalmology and Eye Disorders
- Ergonomics and Musculoskeletal Disorders
- Non-Invasive Vital Sign Monitoring
City, University of London
2015-2024
University of California, San Francisco
2023
University of London
1978-2021
Imperial College London
1996-2016
Chelsea and Westminster Hospital NHS Foundation Trust
2011
Northampton Community College
2008-2009
St Mary's Hospital
2008
St. Mary's Hospital
2008
Hillingdon Hospital
2008
St Mary's Hospital
1997-2007
Retinopathy of prematurity (ROP) is a potentially avoidable cause blindness in children. The proportion as result ROP varies greatly among countries depending on their level development, being influenced by the availability neonatal care, outcomes, and whether effective screening treatment programs are place. objective this study was to compare characteristics premature infants who developed severe between 1996 2002 highly with less countries.This an observational study. A questionnaire...
purpose. Amblyopia is the commonest visual disorder of childhood. Yet contributions two principal treatments (spectacle wear and occlusion) to outcome are unknown. This study was undertaken investigate dose-response relationship amblyopia therapy. methods. The comprised three distinct phases: baseline, in which repeat measures function were confirm initial deficit; refractive adaptation: an 18-week period spectacle with six weekly measurements logarithm minimum angle resolution (logMAR)...
A prospective study of retinopathy prematurity (ROP) 505 infants who weighed <1701 g at birth was undertaken in the mid-1980s. This cohort traced 10 to 12 years age determine how low weight alone and ROP might influence their ophthalmic outcome.Outcome measures were 1) visual functions (visual acuity, contrast sensitivity, stereoacuity, perimetry, color vision), 2) presence strabismus, 3), measurements eye size dimensions its components including refractive state. total 169 11-year-olds born...
Hospital-nursery lighting has been suggested as a factor in causing retinopathy of prematurity. Despite ongoing debate, causal relation not established.We conducted prospective, randomized, multicenter study the effects light reduction on 409 premature infants with birth weights less than 1251 g and gestational ages 31 weeks. Two hundred five were exposed to reduced light, 204 typical nursery lighting. The amount reaching infants' eyes was within 24 hours after by placing goggles that...
To determine, with novel software, the feasibility of measuring tortuosity and width retinal veins arteries from digital images infants at risk retinopathy prematurity (ROP).The Computer-Aided Image Analysis Retina (CAIAR) program was developed to enable semiautomatic detection vasculature measurement vessel images. CAIAR tested for accuracy reproducibility measurements by using computer-generated vessel-like lines known frequency, amplitude, width. then clinical correlation readings...
<b>Objectives</b> To compare visual outcome in response to two prescribed rates of occlusion (six hours a day and 12 day). <b>Design</b> Unmasked randomised trial. <b>Setting</b> Research clinics London hospitals. <b>Participants</b> 97 children with confirmed diagnosis amblyopia associated strabismus, anisometropia, or both. <b>Interventions</b>: 18 week period wearing glasses (refractive adaptation) followed by (“patching”) for six day. <b>Main measures</b> Visual acuity measured logMAR...
<h2>Abstract</h2><h3>Background</h3> The use of chemotherapy to manage newly diagnosed low grade glioma (LGG) was first introduced in the 1980s. One randomised trial has studied two- versus four-drug regimens with a duration 12 months treatment after resection. <h3>Methods</h3> Within European comprehensive strategy for childhood LGG, International Society Paediatric Oncology–Low Grade Glioma (SIOP LGG) Committee launched involving 118 institutions and 11 countries investigate addition...
Explore compliance with occlusion treatment of amblyopia in the Monitored and Randomized Occlusion Treatment Amblyopia Studies (MOTAS ROTAS), using objective monitoring.Both studies had a three-phase protocol: initial assessment, refractive adaptation, occlusion. In phase, participants were instructed to dose for 6 hours/day (MOTAS) or randomized 12 hour/day (ROTAS). Dose was monitored continuously an monitor (ODM).One hundred fifty-two patients (71 male, 81 female; 122 Caucasian, 30...
To validate a vascular severity score as an appropriate output for artificial intelligence (AI) Software Medical Device (SaMD) retinopathy of prematurity (ROP) through comparison with ordinal disease labels stage and plus assigned by the International Classification Retinopathy Prematurity, Third Edition (ICROP3), committee.Validation study AI-based ROP score.A total 34 experts from ICROP3 committee.Two separate datasets 30 fundus photographs each (0-5) (plus, preplus, neither) were labeled...
To identify factors that influence the outcome of treatment for unilateral amblyopia, as a part Monitored Occlusion Treatment Amblyopia Study (MOTAS).This was an intervention study consisting three nonoverlapping phases: "Baseline", "refractive adaptation" (18 weeks full-time spectacle wear), and "occlusion" (6 hours patching per day, objectively monitored). Condition factors: type age participant, initial severity fixation, binocular vision status; refractive adaptation occlusion (total...
AIM/BACKGROUND--This study aimed to determine the feasibility of objective compliance monitoring amblyopia therapy in clinical research. Occlusion has been mainstay for over 250 years, yet it never subjected rigorous evaluation. Treatment regimens range arbitrarily from a few minutes most waking hours day. Compliance is problematic and as, hitherto, accurate impossible not known how much occlusion required effect an improvement vision. METHODS--An dose monitor (ODM) developed. The ODM...