A5071663910- Functional Brain Connectivity Studies
- Transcranial Magnetic Stimulation Studies
- Neural and Behavioral Psychology Studies
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- EEG and Brain-Computer Interfaces
- Neural dynamics and brain function
- Attention Deficit Hyperactivity Disorder
- Muscle activation and electromyography studies
- Neurological disorders and treatments
- Behavioral Health and Interventions
- Spaceflight effects on biology
- Toxin Mechanisms and Immunotoxins
- Photoreceptor and optogenetics research
- Cellular transport and secretion
- Electromagnetic Fields and Biological Effects
- Venomous Animal Envenomation and Studies
- Memory and Neural Mechanisms
- Action Observation and Synchronization
- Pain Management and Treatment
Medical University of South Carolina
2018-2025
University of Iowa
2023-2024
University of Illinois Urbana-Champaign
2021
VA Palo Alto Health Care System
2020
Stanford University
2020
Neurosciences Institute
2020
Background: Published results of our Phase I safety and feasibility trial accelerated intermittent theta burst stimulation (a-iTBS) in mild cognitive impairment (MCI) due to Alzheimer's disease showed a large effect-size improvement cognition.Objective: Further demonstrate target engagement by identifying whether changes local network-level functional connectivity relate the observed improvement.Methods: Eighteen patients with MCI received 3-day a-iTBS (8 sessions/day) left dorsolateral...
Published results of our Phase I safety and feasibility trial accelerated intermittent theta burst stimulation (a-iTBS) in mild cognitive impairment (MCI) due to Alzheimer's disease showed a large effect-size improvement cognition. Further demonstrate target engagement by identifying whether changes local network-level functional connectivity relate the observed improvement. Eighteen patients with MCI received 3-day a-iTBS (8 sessions/day) left dorsolateral prefrontal cortex at Beam F3...
Abstract We are just beginning to understand how spaceflight may impact brain function. As NASA proceeds with plans send astronauts the Moon and commercial space travel interest increases, it is critical human peripheral nervous system respond zero gravity. Here, we developed refined head-worn transcranial magnetic stimulation (TMS) systems capable of reliably quickly determining amount electromagnetism each individual needs detect electromyographic (EMG) threshold levels in thumb (called...
Abstract The approach–avoidance task (AAT) is designed to measure implicit motivated action biases instantiated by emotional stimuli and alterations in such that drive psychiatric disorder. While some research has measured AAT event‐related potential (ERP) correlates establish bias sensitivity even at a neural level, lack of work with unpleasant, pleasant, neutral together common focus on disorder‐matched (rather than generally emotional) content limits conclusions can be drawn. Thus,...
The cellular specificity, potency, and modular nature of bacterial protein toxins enable their application for targeted cytosolic delivery therapeutic cargo. Efficient endosomal escape is a critical step in the design toxin-inspired drug (BTIDD) vehicles to avoid lysosomal degradation promote optimal cargo delivery. cytotoxic necrotizing factor (CNF) family represents useful model investigating cargo-delivery mechanisms due availability many homologs with high sequence identity, flexibility...
Abstract Background The perturbational complexity index (PCI) is a useful measure of consciousness that combines transcranial magnetic stimulation (TMS) with electroencephalography (EEG). However, the PCI has not been assessed for reliability between sessions nor there clear best target to acquire PCI. Objective/Hypothesis We within-subject PCIs 3 over same premotor, motor, and parietal targets visits, hypothesizing we could determine most reliable TMS-EEG in healthy, conscious adults....
Abstract Background Repetitive transcranial magnetic stimulation enhances cognition in people with mild cognitive impairment (MCI). Whereas conventional treatment requires daily sessions for 4‐6 weeks, accelerated intermittent theta burst (iTBS) shortens the course to just 3 days, substantially improving feasibility of use MCI. We conducted a Phase I safety and trial iTBS MCI, finding preliminary evidence improvement. Here, we explore neural mechanism this effect by evaluating iTBS‐related...
The Approach-Avoidance Task (AAT) is designed to 1) measure the implicit motivated action biases that are instantiated by emotional stimuli, and 2) assess changes in such drive psychiatric disorder. To establish AAT sensitivity bias at a neural level, some work has measured event-related potential (ERP) correlates — however, lack of research with unpleasant, pleasant, neutral stimuli together also common focus on disorder-matched (rather than generally evocative) content limits foundational...
Objective: Repetitive transcranial magnetic stimulation (rTMS), a non-invasive neuromodulation therapy most widely used in depression, has shown evidence of secondary benefits for cognition both neurologic and neuropsychiatric conditions. The recent development more efficient protocols, such as accelerated high-dose intermittent theta burst (iTBS)-rTMS, substantially reduced treatment burden by shortening the course >50%. This study aimed to establish safety, feasibility, acceptability,...