A5015669709- Medical Imaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Traumatic Brain Injury and Neurovascular Disturbances
- Cerebrovascular and Carotid Artery Diseases
- Neuroscience and Neuropharmacology Research
- Glioma Diagnosis and Treatment
- Acute Ischemic Stroke Management
- Radiopharmaceutical Chemistry and Applications
- MRI in cancer diagnosis
- Intracranial Aneurysms: Treatment and Complications
- Lanthanide and Transition Metal Complexes
- Antimicrobial Resistance in Staphylococcus
- Diabetes Treatment and Management
- Neuroinflammation and Neurodegeneration Mechanisms
- Chronic Lymphocytic Leukemia Research
- Pancreatic function and diabetes
- Neurological Disease Mechanisms and Treatments
- Cancer therapeutics and mechanisms
- Optical Imaging and Spectroscopy Techniques
- Chronic Myeloid Leukemia Treatments
- Antibiotics Pharmacokinetics and Efficacy
- Metabolism, Diabetes, and Cancer
- Mitochondrial Function and Pathology
- Peptidase Inhibition and Analysis
- Colorectal Cancer Treatments and Studies
Sojo University
2017-2025
Hiroshima University
2023-2024
Kanazawa University
2022
St. Marianna University School of Medicine
2019-2020
Yokohama City Seibu Hospital
2019
National Defense Medical College
2017-2018
National Cancer Research Institute
2018
Montreal Neurological Institute and Hospital
1986-1997
McGill University
1986-1997
Yamamoto Hospital
1987
We describe here an autoradiographic method to measure the in vivo rate of serotonin synthesis rat brain. The is based on use l-tryptophan analogue a-methyl-l-tryptophan ( a-MTrp), which converted into a-methylserotonin a-M5HT). Since a-M5HT not a substrate for monoamine oxidase, it accumulated brain tissue. Data are presented confirm time-dependent conversion a-MTrp dorsal raphe nucleus and also pineal body, organ outside blood–brain barrier. It has been shown that washing slices 10%...
✓ Effects of intracarotid infusion prostaglandins (PG) E 1 and F 2 a on the circulation to dog brain were examined by fluorescein angiography, measuring diameter changes in epicerebral vessels, microregional cerebral blood flow with 133 xenon lithium-drift silicon detectors. PGE at doses 0.5 µg/min constricted arteries 700 µ or less diameter, arrested dye injected into carotid system, reduced rCBF 42% increase collateral vertebrobasilar system. This effect was not obtained which 0.08%...
✓ The circulation through an arteriovenous malformation and the microcirculation of surrounding brain were examined during craniotomy by fluorescein angiography microregional blood flow measurements using xenon 133 Neohydrin-Hg 197 . evidence indicates that occluding arterial supply to angioma obliterated cerebral steal reducing shunt or non-nutritional improving perfusion cortical microcirculation. features characterizing syndrome are described.
Abstract Twelve patients were studied within 48 hours of stroke using positron emission tomography to determine cerebral blood flow (CBF), metabolic rate for oxygen (CMRo 2 ), extraction fraction, volume, pH (CpH), and glucose (CMRGlc), the last calculated published normal constants (CMRGlc[N]) those severe ischemia. In these studies, a cortical region ischemia (I) was outlined, its perfusion properties evaluated, length measured. The contralateral uninvolved rim (C) in 5 older used...
Abstract: In vivo measurements by positron emission tomography of the brain serotonin synthesis rates in normal dog, dog with increased plasma tryptophan concentration, and under different arterial oxygen tensions are described. The method described here permits repeated same for first time. An increase concentration from 16.6 to 191.5 then 381 μ M resulted close a linear rate. When P O 2 was raised 76 ± 106 1 mm Hg, rate 39 8 54 10 pmol g −1 min . estimates Michaelis‐Menten constants, K app...
Positron emission tomography was used to measure cerebral perfusion and metabolism in 7 patients with severe carotid stenosis. None of the had sustained a major stroke, all normal neurological examination except 1 patient mild deficit from capsular lacuna. Cerebral blood flow (CBF), volume, flow/cerebral volume ratio, oxygen metabolism, fractional extraction by brain were measured cortex both hemispheres anterior middle artery distributions, borderzone regions between arteries (anterior...
✓ A branch of the middle cerebral artery on convexity dog brain was occluded to produce an area focal ischemia which could then be defined by fluorescein angiography brain. Repeated and measurement microregional blood flow xenon 133 injected into carotid monitored miniature lithium-drifted silicon detectors for gamma activity demonstrated that ischemic zone reduced in size better collateral when animals were allowed breathe 5% carbon dioxide 95% oxygen. Conversely, hyperventilation reducing...
Type 2 diabetes is associated with sarcopenia. Resistance training and appropriate nutritional therapy are reported to be effective for muscle strength mass. This study aimed evaluate the effect of resistance using elastic bands at home combined a leucine-rich amino acid supplement on strength, physical function, mass in elderly type diabetes. We conducted 48-week prospective single-center randomized controlled trial 60 patients who were randomly allocated one three groups: control (C),...
Regional cerebral blood volume (CBV) can be calculated using data obtained during the kinetic analysis of 18 F-labeled 2-fluoro-2-deoxy-d-glucose (FDG) uptake measured by positron emission tomography (PET). As a result influence vascular activity upon determination FDG rate constants minimized. The method is investigated simulation experiments and PET studies on seven older, healthy human volunteers aged 52–70 years. accuracy k 1 , 2 3 either omitting early portion curve or explicit...
THOUGH many radioactive isotopes have been tried for brain scanning, the most widely used arsenic 74 and iodine 1~1 tagged onto serum albumin (RISA). With these agents a variety of scanning methods satisfactory detection has reported in 80 per cent or more patients who subsequently proved to intracranial tumours. 2,4,~,9 But each radioisotopes, despite its usefulness, certain disadvantages. Arsenic 74, although applied successfully over past 10 years, remains costly is difficult obtain...
Triple-tracer autoradiography was used to measure topographic changes in local cerebral blood flow, tissue pH, and glucose utilization hyperglycemic normoglycemic rats, all of which had undergone occlusion the middle artery. More severe extensive reduction three variables observed than rats. In seven significant flow (p less 0.025) ischemic but not contralateral nonischemic side at lateral portion caudate nucleus neocortex. Tissue pH significantly lower only side. No differences were when...
Seventeen patients with an intracranial arteriovenous malformation were studied positron emission tomography. Cerebral blood flow, cerebral volume, oxygen extraction fraction, and glucose metabolism evaluated in both hemispheres, excluding the area of itself. Patients divided into three groups according to size their malformation, results obtained compared studies healthy volunteers. The was significantly (p less than 0.01) decreased ipsilateral hemisphere all patients. volume increased...
"Blood Flow Patterns in the Cerebral Vessels and Cortex Man Studied by Intracarotid Injection of Radioisotopes Coomassie Blue Dye" published on Jul 1965 Journal Neurosurgery Publishing Group.
Primary macronodular adrenal hyperplasia (PMAH) is a rare type of Cushing or subclinical syndrome and associated with bilateral multinodular formation. ARMC5 one the responsible genes for PMAH.This study was performed to identify genotype-phenotype correlation in cohort Japanese patients.Fourteen patients clinically diagnosed PMAH family members selected were studied gene alteration clinical phenotype. The nonadrenal tumor tissues also studied.Of fourteen PMAH, 10 had pathogenic likely...
We examined the rate of glucose utilization and valine incorporation into proteins using 2-[ 18 F]fluoro-2-deoxyglucose L-[1- 14 C]-valine in a rat brain tumor model by quantitative double-tracer autoradiography. found that implanted was about 22 times 1.5 contralateral cortex. (In ipsilateral cortex, had profound effect on but no proteins.) Our findings suggest it is more useful to measure protein synthesis than assess effectiveness antitumor agents their toxicity normal tissue. compared...
Lumped and transfer rate constants in ischemic brain tissue must be measured to estimate accurately cerebral glucose utilization by the deoxyglucose method. We studied bilateral middle artery occlusion model 17 cats, 5 with a 1-hour occlusion, 4-hour 7 sham operation. The time course of radioactivity (Ci*(t)) was monitored external coincidence counting during programmed infusion [18F]-2-deoxy-2-fluoro-d-glucose (18F-2-FDG). Arterial plasma concentration (Cp*(t)) tracer kept constant first 45...
Abstract: The effect of treatment with acute fluoxetine, a serotonin reuptake inhibitor, on the rate synthesis in rat brain was studied through autoradiography following intravenous administration α‐methyl‐ l ‐[ 3 H]tryptophan. fluoxetine‐treated rats compared measured sham‐treated (saline injection). Results showed significant increase majority cerebral structures examined. greatest (given as percentage rates control animals) observed substantia nigra compacta (344%), hippocampus‐CA3...