A5100423548- Microbial Community Ecology and Physiology
- Genomics and Phylogenetic Studies
- Polar Research and Ecology
- Neuroscience and Neuropharmacology Research
- SARS-CoV-2 and COVID-19 Research
- Computational Drug Discovery Methods
- Bacteriophages and microbial interactions
- Parallel Computing and Optimization Techniques
- Plant Stress Responses and Tolerance
- Viral Infections and Vectors
- Embedded Systems Design Techniques
- RNA Interference and Gene Delivery
- Real-Time Systems Scheduling
- Cannabis and Cannabinoid Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Radiopharmaceutical Chemistry and Applications
- Advanced biosensing and bioanalysis techniques
- Air Quality and Health Impacts
- Plant Pathogens and Fungal Diseases
- Topic Modeling
- Domain Adaptation and Few-Shot Learning
- Cancer therapeutics and mechanisms
- Protist diversity and phylogeny
- Seed Germination and Physiology
- DNA and Nucleic Acid Chemistry
Wuhan Institute of Virology
2021-2025
Chinese Academy of Sciences
2021-2025
Huazhong University of Science and Technology
2013-2025
Nanjing Medical University
2024-2025
Nanjing Brain Hospital
2024-2025
Mianyang Third People's Hospital
2025
Tianjin Anding Hospital
2025
The First People's Hospital of Changzhou
2025
Nanjing Normal University
2025
Wuhan University
2015-2024
Abstract The ongoing pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome 2 (SARS-CoV-2) urgently needs an effective cure. 3CL protease (3CL pro ) is a highly conserved cysteine proteinase that indispensable for replication, providing attractive target developing broad-spectrum antiviral drugs. Here we describe the discovery myricetin, flavonoid found in many food sources, as non-peptidomimetic and covalent inhibitor SARS-CoV-2 . Crystal structures...
In this paper, we present a two-phase framework that integrates task assignment, ordering and voltage selection (VS) together to minimize energy consumption of real-time dependent tasks executing on given number variable processors. Task assignment in the first phase strive maximize opportunities can be exploited for lowering levels during second phase, i.e., selection. formulate VS problem as an Integer Programming (IP) solve IP efficiently. Experimental results demonstrate our is very...
Peroxynitrite toxicity is a major cause of neuronal injury in stroke and neurodegenerative disorders. The mechanisms underlying the neurotoxicity induced by peroxynitrite are still unclear. In this study, we observed that TPEN [ N,N,N ′, N ′-tetrakis (2-pyridylmethyl)ethylenediamine], zinc chelator, protected against exogenous as well endogenous (coadministration NMDA nitric oxide donor, diethylenetriamine NONOate) peroxynitrite. Two different approaches to detecting intracellular release...
Accumulation evidence shows that β-amyloid (Aβ) is a neurotoxic and accumulation of Aβ responsible for the pathology Alzheimer's disease (AD). However, it currently not fully understood what makes toxic accumulated. Previous studies demonstrate suitable substrate glycation, producing one form advanced glycation endproducts (AGEs). We speculated Aβ-AGE formation may exacerbate neurotoxicity. To explore whether more than authentic to understand molecular mechanisms, we synthesized glycated by...
Raffinose and its precursor galactinol accumulate in plant leaves during abiotic stress. RAFFINOSE SYNTHASE (RAFS) catalyzes raffinose formation by transferring a galactosyl group of to sucrose. However, whether RAFS contributes drought tolerance and, if so, what mechanism remains unclear. In this study, we report that expression from maize (or corn, Zea mays) (ZmRAFS) is induced drought, heat, cold, salinity stresses. We found zmrafs mutant plants completely lack hyper-accumulate are more...
Summary Raffinose is thought to play an important role in plant tolerance of abiotic stress. We report here that maize HEAT SHOCK FACTOR A2 (Zm HSFA 2) and BINDING PROTEIN 2 HSBP physically interact with each other antagonistically modulate expression GALACTINOL SYNTHASE ( Zm GOLS ) raffinose biosynthesis transformed protoplasts Arabidopsis plants. Overexpression increased the At 1 , RS 5 RAFFINOSE ), content leaves enhanced heat stress tolerance. Contrary overexpression decreased reduced...
Abstract Respiratory disease caused by coronavirus infection remains a global health crisis. Although several SARS-CoV-2-specific vaccines and direct-acting antivirals are available, their efficacy on emerging coronaviruses in the future, including SARS-CoV-2 variants, might be compromised. Host-targeting provide preventive therapeutic strategies to overcome resistance manage future outbreak of coronaviruses. Cathepsin L (CTSL) calpain-1 (CAPN1) host cysteine proteases which play crucial...
Glutamate transporters maintain low synaptic concentrations of neurotransmitter by coupling uptake to flux other ions. After cotransport glutamic acid with Na+, the cycle is completed countertransport K+. We have identified an amino residue (glutamate 404) influencing ion in a domain transporter implicated previously kainate binding. Mutation this aspartate (E404D) prevents both forward and reverse transport induced Sodium-dependent transmitter exchange transporter-mediated chloride...
In this paper, we present a two-phase framework that integrates task assignment, ordering and voltage selection (VS) together to minimize energy consumption of real-time dependent tasks executing on given number variable processors. Task assignment in the first phase strive maximize opportunities can be exploited for lowering levels during second phase, i.e., selection. formulate VS problem as an Integer Programming (IP) solve IP efficiently. Experimental results demonstrate our is very...
Rhamnolipids are a mixture of the homologs species due to variations in rhamnose units and β-hydroxy fatty acid moieties, mainly including Rha-C10-C10, Rha-Rha-C10-C10, Rha-C10. In this study, strain P. aeruginosa YM4 was selected for its capacity efficiently produce di-rhamnolipid (Rha-Rha-C10-C10) as predominant component with soybean oil glycerol carbon source, accounting 64.8% 85.7% total products, respectively. The critical micelle concentration (CMC) rhamnolipid products varies content...
Streptococcus agalactiae (Group B Streptococcus, GBS) is a multi-host pathogen, even causing life-threatening infections in newborns. Vaccination with GBS crossed serotypes vaccine one of the best options for long-term infection control. Here we built comprehensive silico epitope-prediction workflow pipeline to design multivalent multiepitope-based subunit containing 11 epitopes against (MVSA). All MVSA came from proteins which were antigenic-confirmed, virulent-associated, surface-exposed...
Abstract Since 2019, SARS-CoV-2 has evolved rapidly and gained resistance to multiple therapeutics targeting the virus. Development of host-directed antivirals offers broad-spectrum intervention against different variants concern. Host proteases, TMPRSS2 CTSL/CTSB cleave spike play a crucial role in two alternative pathways viral entry are characterized as promising pharmacological targets. Here, we identify compounds that show potent inhibition these proteases determine their complex...
Abstract Oxidative injury to premyelinating oligodendrocytes (preOLs) in developing white matter has been implicated the pathogenesis of periventricular leukomalacia, lesion underlying most cases cerebral palsy premature infants. In this study, we investigated pathways OL death induced by intracellular glutathione (GSH) depletion. We found that lipoxygenase (LOX) inhibitors AA‐861 and BMD‐122 (N‐benzyl‐N‐hydroxy‐5‐phenylpentamide; BHPP), but not cyclooxygenase (COX) inhibitor indomethacin,...
Glutamate transporters remove this neurotransmitter from the synaptic cleft by a two-stage electrogenic process, in which glutamate is first cotransported with three sodium ions and proton. Subsequently, cycle completed translocation of potassium ion opposite direction. Recently, we have identified an amino acid residue transporter GLT-1 (Glu-404) that influences coupling. We now analyzed effect seven other residues highly conserved region surrounding site. One these residues, Tyr-403, also...
The neurotoxicity of glutamate in the central nervous system is restricted by several (Na + K )-coupled transporters for this neurotransmitter. astroglial transporter GLT-1 only subtype that exhibits high sensitivity to nontransportable analogue dihydrokainate. A marked reduction blocker observed when serine residues 440 and 443 are mutated glycine glutamine, which, respectively, occupy these positions other homologous transporters. They located ascending limb recently identified...