A5014567804- Mental Health Treatment and Access
- Treatment of Major Depression
- Mental Health Research Topics
- Digital Mental Health Interventions
- Child and Adolescent Psychosocial and Emotional Development
- Health, psychology, and well-being
- Schizophrenia research and treatment
- Maternal Mental Health During Pregnancy and Postpartum
- Psychosomatic Disorders and Their Treatments
- Health Systems, Economic Evaluations, Quality of Life
- Meta-analysis and systematic reviews
- Long-Term Effects of COVID-19
- Mobile Health and mHealth Applications
- Health Literacy and Information Accessibility
- Sleep and related disorders
- Tryptophan and brain disorders
- Psychiatric care and mental health services
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Adolescent and Pediatric Healthcare
- Chronic Disease Management Strategies
- Mental Health and Psychiatry
- Family Caregiving in Mental Illness
- Autoimmune Neurological Disorders and Treatments
- Stress Responses and Cortisol
- Cardiac Health and Mental Health
University of York
2015-2024
Hull York Medical School
2017-2024
Keele University
2024
Department of Medical Sciences
2020
Newcastle University
2012-2014
Royal Victoria Infirmary
2013
Newcastle upon Tyne Hospital
2012
St. Vincent's University Hospital
2004
Objective To investigate the effectiveness of a complex behavioural intervention, ProLife, on tuberculosis (TB) treatment success, medication adherence, alcohol use and tobacco smoking. Design Multicentre, individual, randomised controlled trial where participants were assigned (1:1) to ProLife intervention or usual care. Setting 27 primary care clinics in South Africa. Participants 574 adults starting for drug-sensitive pulmonary TB who smoked reported harmful/hazardous use. Interventions...
The association between hypothalamic-pituitary-adrenal (HPA)-axis function and cognition has long been investigated. An inverted U-shaped relationship described various measures of HPA-axis neuropsychological performance in animals man. Work with glucocorticoid receptor manipulation corroborated these findings, particular effects observed relation to spatial working memory (SWM). As dysfunction is frequently found patients psychiatric illness, research this area potential implications for...
This study establishes research priorities for medically not yet explained symptoms (MNYES), also known as persistent physical or unexplained symptoms, from the perspective of patients, caregivers and clinicians, in a priority setting partnership (PSP) following James Lind Alliance (JLA) approach. Research into such general has been poorly funded over years so far primarily researcher-led with minimal input clinicians; sometimes controversial.
South Africa is among the seven highest tuberculosis (TB) burden countries. Harmful lifestyle behaviours, such as smoking and alcohol, poor adherence to medication can affect clinical outcomes. Modification of these behaviours likely improve TB treatment outcomes has proven possible using motivational interviewing (MI) techniques or use short message service (SMS) text messaging. There have been no studies assessing effect combined MI SMS interventions on multiple factors outcomes.This a...
Relapse contributes to the clinical and societal burden associated with depression. It is not well understood how relapse risk prevention are managed discussed between patients GPs in primary care. To understand extent which general practice. A qualitative study undertaken practice UK. Participants were recruited through practices. Data generated using semi-structured interviews analysed thematic analysis. Patient public involvement informed all aspects of study. Twenty-three people lived...
There have been suggestions that Long COVID might be purely functional (meaning psychological) in origin. Labelling patients with neurological dysfunction as having disorder (FND) the absence of proper testing may symptomatic line thought. This practice is problematic for patients, motor and balance symptoms reported to occur frequently. FND characterized by presentation seem but lack compatibility symptom a substrate. Although diagnostic classification according ICD-11 DSM-5-TR dependent...
Background Subclinical hypothyroidism (SCH) is a common endocrine problem with prevalence estimates between 4% and 20%. Symptoms are often non-specific but can substantially affect well-being leading to repeated medical consultations. The effect of thyroid hormone replacement therapy (THRT) in patients SCH remains uncertain. Current guidelines, limited by the lack high-quality evidence, have been controversial adherence clinical practice. Methods Three-round modified Delphi method establish...
Most patients who present with depression are treated in primary care by general practitioners (GPs). Relapse of is common (at least 50% for will relapse after a single episode) and leads to considerable morbidity decreased quality life patients. The majority within 6 months, those history more likely the future than no such history. GPs see largely undifferentiated case-mix patients, once reach remission, there limited guidance help stratify according risk relapse. We aim develop prognostic...
ABSTRACT Background Relapse of depression is common and contributes to the overall associated morbidity burden. We lack evidence-based tools estimate an individual’s risk relapse after treatment in primary care, which may help us more effectively target prevention. Objective Develop validate a prognostic model predict care. Methods Multilevel logistic regression models were developed, using individual participant data from seven care-based studies (n=1244), depression. The was internally...
Background Relapse of depression is common and contributes to the overall associated morbidity burden. We lack evidence-based tools estimate an individual’s risk relapse after treatment in primary care, which may help us more effectively target prevention. Objective The objective was develop validate a prognostic model predict care. Methods Multilevel logistic regression models were developed, using individual participant data from seven care-based studies (n=1244), depression. internally...
ABSTRACT Introduction Prediction models are increasingly being used to guide clinical decision making in primary care. There is a lack of evidence exploring the views patients and general practitioners (GPs) care around their use implementation. We aimed better understand perspectives GPs people with lived experience depression prediction communication risk Methods Qualitative methods were used. Data generated over 6 months (April October 2022) through semi‐structured interviews 23 22 GPs. A...
Abstract Background South Africa is among the 7 highest tuberculosis (TB) burden countries. Harmful lifestyle behaviours, such as smoking and alcohol, poor medication adherence can affect clinical outcomes. Modification of these behaviours likely to improve TB treatment outcomes has proven possible using motivational interviewing (MI) techniques or use short message service (SMS) text messaging. There have been no studies assessing effect combined MI SMS interventions on multiple factors...
Sleep problems are a transdiagnostic feature of nearly all psychiatric conditions, and strong risk factor for initial recurrent episodes. However, people with severe mental ill health (SMI) often excluded from general population surveys, as such the extent associates poor sleep in this less well understood. This study explores an SMI sample during COVID-19 pandemic, using multiple regression to identify factors, including daily routine, wellbeing demographics. An existing cohort diagnosis...
Background Cognitive impairment is a major source of morbidity in mood disorders. Sleep disturbance affects 90% patients with these disorders and remains an under-researched, potentially significant contributor to common cognitive deficits. Aims To investigate the association between sleep functions commonly impaired Methods Subjective objective parameters quality were measured using questionnaires overnight study 21 healthy male subjects. Subjects then tested battery neuropsychological...