A5038387335- Solar Radiation and Photovoltaics
- Computational Physics and Python Applications
- Distributed and Parallel Computing Systems
- Solar and Space Plasma Dynamics
- Protein Degradation and Inhibitors
- Scientific Computing and Data Management
- Ubiquitin and proteasome pathways
- Research on Leishmaniasis Studies
- Tuberculosis Research and Epidemiology
- Trypanosoma species research and implications
- Multiple Myeloma Research and Treatments
- Computational Drug Discovery Methods
- Big Data Technologies and Applications
- Astronomical Observations and Instrumentation
- Bioinformatics and Genomic Networks
- Image Retrieval and Classification Techniques
- interferon and immune responses
- Ultrasonics and Acoustic Wave Propagation
- Welding Techniques and Residual Stresses
- Satellite Image Processing and Photogrammetry
- Big Data and Business Intelligence
- Cloud Computing and Resource Management
- Cytokine Signaling Pathways and Interactions
- Non-Destructive Testing Techniques
- Parasites and Host Interactions
National Cancer Institute
2020-2025
Center for Cancer Research
2020-2025
National Institutes of Health
2021
University of Maryland, College Park
2015-2020
Cancer Genetics (United States)
2019
ORCID
2019
Adnet Systems (United States)
2009
Abstract The goal of the SunPy project is to facilitate and promote use development community-led, free, open source data analysis software for solar physics based on scientific Python environment. achieves this by developing maintaining sunpy core package supporting an ecosystem affiliated packages. This paper describes first official stable release (version 1.0) package, as well organization infrastructure. concludes with a discussion future project.
The cell wall of Mycobacterium tuberculosis is composed unique lipids that are important for pathogenesis. Indeed, the first-ever genetic screen in M. identified genes involved biosynthesis and transport lipid PDIM (phthiocerol dimycocerosates) as crucial survival mice. Here we show evidence a novel molecular mechanism PDIM-mediated virulence We characterized DNA interaction regulon Rv3167c, transcriptional repressor regulation tuberculosis, discovered it controls operon. A loss-of-function...
ABSTRACT The life cycle of the Leishmania parasite in sand fly vector involves differentiation into several distinctive forms, each thought to represent an adaptation specific microenvironments midgut fly. Based on transcriptome sequencing (RNA-Seq) results, we describe first high-resolution analysis dynamics four distinct stages major as they develop a natural vector, Phlebotomus duboscqi . early transformation from tissue amastigotes procyclic promastigotes blood-fed was accompanied by...
Protozoan parasites of the genus Leishmania are etiological agents leishmaniasis, a group diseases with worldwide incidence 0.9-1.6 million cases per year.We used RNA-seq to conduct high-resolution transcriptomic analysis global changes in gene expression and RNA processing events that occur as L. major transforms from non-infective procyclic promastigotes infective metacyclic promastigotes.Careful statistical across multiple biological replicates removal batch effects provided high quality...
Host and parasite gene expression in skin biopsies from Leishmania braziliensis-infected patients were simultaneously analyzed using high throughput RNA-sequencing. Biopsies taken 8 with early cutaneous leishmaniasis 17 late leishmaniasis. Although DNA was found all patient lesions at the time of biopsy, could be stratified into two groups: one lacking detectable transcripts (PTNeg) lesions, another which readily detected (PTPos). These groups exhibited substantial differences host responses...
Small cell lung cancer (SCLC) is a recalcitrant malignancy with limited treatment options. Bromodomain and extraterminal domain inhibitors (BETis) have shown promising preclinical activity in SCLC, but the broad sensitivity spectrum limits their clinical prospects. Here, we performed unbiased high-throughput drug combination screens to identify therapeutics that could augment antitumor activities of BETis SCLC. We found multiple drugs targeting PI-3K–AKT–mTOR pathway synergize BETis, among...
All disciplines that work with image data-from astrophysics to medical research and historic preservation-increasingly require efficient ways browse inspect large sets of high-resolution images. Based on the JPEG 2000 image-compression standard, JHelioviewer solar visualization tool lets users petabyte-scale archives as well locate manipulate specific data sets.
The type I IFNs (IFN-α and -β) are important for host defense against viral infections. In contrast, their role in nonviral pathogens is more ambiguous. this article, we report that IFN-β signaling murine bone marrow-derived macrophages has a cell-intrinsic protective capacity Mycobacterium tuberculosis via the increased production of NO. antimycobacterial effects were mediated by direct through IFN-α/β-receptor (IFNAR), as Ab-mediated blocking IFNAR1 prevented Furthermore, M. able to...
Abstract Multiple myeloma, a hematopoietic malignancy of terminally differentiated B cells, is the second most common hematological after leukemia. While patients have benefited from numerous advances in treatment recent years resulting significant increases to average survival time following diagnosis, myeloma remains incurable and relapse common. To help identify novel therapeutic agents with efficacy against disease search for biomarkers associated differential response treatment,...
Abstract Identification of modules in molecular networks is at the core many current analysis methods biomedical research. However, how well different approaches identify disease-relevant types gene and protein remains poorly understood. We launched “Disease Module DREAM Challenge”, an open competition to comprehensively assess module identification across diverse protein-protein interaction, signaling, co-expression, homology, cancer-gene networks. Predicted network were tested for...
Proteasome subunit hRpn13 is partially proteolyzed in certain cancer cell types to generate hRpn13Pru by degradation of its UCHL5/Uch37-binding DEUBAD domain and retention an intact proteasome- ubiquitin-binding Pru domain. By using structure-guided virtual screening, we identify binder (XL44) solve structure ligated integrated X-ray crystallography NMR reveal targeting mechanism. Surprisingly, depleted myeloma cells following treatment with XL44. TMT-MS experiments a select group...
To maintain homeostasis, macrophages must be capable of assuming either an inflammatory or anti-inflammatory phenotype. better understand the latter, we stimulated human in vitro with TLR ligands presence high-density immune complexes (IC). This combination stimuli resulted a broad suppression mediators and upregulation molecules involved tissue remodeling angiogenesis. Transcriptomic analysis stimulation IC predicted downstream activation AKT inhibition GSK3. Consequently, pretreated...
<ns4:p>Regional Student Groups are groups established and managed by the ISCB-Student Council in different regions of world. The article highlights some initiatives management lessons from our 'top-performing' Spotlight Regional (RSGs), RSG-Argentina RSG-UK, for current year (2016). In addition, it details operational hurdles faced RSGs possible solutions.</ns4:p>
The Journal of Cancer Metastasis and Treatment is an open access journal focused on cancer metastasis treatment, including the occurrence, development, progression, metastasis, treatment oncologic disease. It covers basic, translational clinical research related to cell biology, genomics, precision medicine, oncology internal radiotherapy radiology, obstetrics gynecology, pediatrics, surgery, hematology, neurooncology, etc.
Summary The type I interferons (IFN- α and - β ) are important for host defense against viral infections. In contrast, their role in non-viral pathogens is more ambiguous. Here we report that IFN-β-signaling macrophages has protective capacity Mycobacterium tuberculosis (Mtb) via the increased production of nitric oxide. Furthermore, Mtb able to inhibit IFN-α/β-receptor-mediated cell signaling transcription 309 IFN- stimulated genes which includes associated with innate defense. molecular...
Abstract Purpose SCLC is a recalcitrant malignancy with limited treatment options. BET inhibitors have shown promising preclinical activity in SCLC, but their broad sensitivity spectrum limits clinical prospects this malignancy. Drug combination could be solution. Experimental design We performed high-throughput drug screens cell lines to identify potential therapeutics synergizing inhibitors. Validation was and patient-derived xenograft models. Genome-wide RNA sequencing of tumors determine...