A5106265558- Gastric Cancer Management and Outcomes
- Cancer Treatment and Pharmacology
- Colorectal Cancer Treatments and Studies
- Advanced Breast Cancer Therapies
- Metallurgical Processes and Thermodynamics
- Cancer Immunotherapy and Biomarkers
- Metastasis and carcinoma case studies
- Neuroendocrine Tumor Research Advances
- Peptidase Inhibition and Analysis
- HER2/EGFR in Cancer Research
- Venous Thromboembolism Diagnosis and Management
- Inflammatory Biomarkers in Disease Prognosis
- Lung Cancer Treatments and Mutations
- Pancreatic and Hepatic Oncology Research
- Advanced ceramic materials synthesis
- Marine and fisheries research
- Chemotherapy-induced cardiotoxicity and mitigation
- Underwater Vehicles and Communication Systems
- IgG4-Related and Inflammatory Diseases
- Erosion and Abrasive Machining
- Case Reports on Hematomas
- Airway Management and Intubation Techniques
- Chemotherapy-related skin toxicity
- Recycling and utilization of industrial and municipal waste in materials production
- Effects and risks of endocrine disrupting chemicals
Hyogo Prefectural Cancer Center
2022
Kobe City Medical Center General Hospital
2017-2021
University of Occupational and Environmental Health Japan
2002
Mitsubishi Motors (Japan)
2002
Fukuoka Institute of Health and Environmental Sciences
2001
The neutrophil-to-lymphocyte ratio (NLR) is effective as a predictive factor for lung cancer treated with nivolumab. objective of this study was to determine the effectiveness NLR patients advanced gastric (AGC) nivolumab.This multicenter, retrospective AGC nivolumab from June 2017 December 2017. NLRs were calculated before first cycle (NLRpre) and two weeks after administration (NLRpost).Twenty-six enrolled (males 19, females 7) median age 64 years. overall response rate 15%. PFS 80 days...
We investigated the effects of chlorophyll derived from Chlorella on gastrointestinal absorption seven types polychlorinated dibenzo-p-dioxin (PCDD) and 10 dibenzofuran (PCDF) in Wistar rats. Twenty-eight rats were randomly distributed into groups (n = 4). After overnight food deprivation, given 4 g basal diet or containing 0.01-0.5% one time day 1; each also contained 0.2 mL PCDD PCDF standard solutions. The amounts fecal excretion congeners days 1 to 5 group fed 0.01% 64.8% for...
Inflammatory myofibroblastic tumor (IMT), a rare sarcoma, is primarily treated via resection of the mass. However, in cases recurrence or unresectable tumors, no standard care exists. While crizotinib, an anaplastic lymphoma kinase (ALK) inhibitor, only approved for non-small-cell lung cancer with ALK mutation, it reportedly effective other malignant tumors mutation. We herein report case involving 37-year-old woman retroperitoneal IMT who experienced after complete resection, whom...
Following the ATTRACTION-2 study, nivolumab was approved for advanced gastric cancer in Japan. However, pseudoprogression and hyperprogressive disease have been reported patients treated with immune checkpoint inhibitors. We report a patient who received after radiotherapy only to experience rapid progression within irradiation field first immunotherapy session. A 66-year-old man dysphagia visited our hospital diagnosed stage IV gastroesophageal (human epidermal growth factor receptor-2...
Regorafenib (REG) and trifluridine/tipiracil (FTD/TPI) showed survival benefits in metastatic colorectal cancer patients previously treated with standard chemotherapies; therefore, we compared the efficacy safety of these two treatments. Patients REG or FTD/TPI as a salvage-line therapy from May 2014 to December 2017 were included. We retrospectively analyzed long-term survival, safety, clinical outcomes. Among 134 patients, 57 77 received FTD/TPI, respectively. The group more prior systemic...
Abstract Background Trastuzumab emtansine (T-DM1) treatment for human epidermal growth factor receptor-2 (HER2)-positive metastatic breast cancer after taxane with trastuzumab and pertuzumab is standard therapy. However, strategies beyond T-DM1 are still in development insufficient evidence of their effectiveness. Here, we aimed to evaluate real-world choice efficacy treatments HER2-positive cancer. Methods In this multi-centre retrospective cohort study involving 17 hospitals, 325 female...
Diffuse liver metastasis is a rare pattern of that associated with hepatic failure and poor prognosis. We experienced 2 cases acute due to diffuse could not be detected using computed tomography. In <i>case 1</i>, it was difficult differentiate from alcoholic hepatitis. 2</i>, diagnose because the patient had no history malignancy. When enzyme levels are elevated, necessary consider as potential cause, regardless tomography findings.
FOLFOXIRI plus bevacizumab has a promising efficacy as first-line systemic chemotherapy for metastatic colorectal cancer (mCRC). This study aimed to evaluate the safety and effectiveness of antibodies.Fifty-five patients were enrolled (median age: 60 years, males: 25, females: 30). Twenty-six subjects had RAS mutations 29 wild-type. Anti-VEGF anti-EGFR antibodies administered 38 17 patients, respectively. The most common severe adverse event was neutropenia (51%). overall response rate (ORR)...
Oxaliplatin-based chemotherapy is widely used to treat advanced cancer. Oxaliplatin-induced hyperammonemic encephalopathy rarely reported. Here, we report a case of oxaliplatin-induced occurring after gemcitabine plus oxaliplatin (GEMOX) in patient with pancreatic A 76-year-old man received GEMOX regimen as first-line treatment for adenocarcinoma peritoneal dissemination. consists (1,000 mg/m2) and (100 on day 1, repeated every 2 weeks. The second cycle was administered planned. However, he...
Nowadays many types of pipe such as water pipes, drain and gas are underground. Also pipeline used in places where people cannot enter, atomic power plants chemical plants. Maintenance these pipes pipelines is an important issue to keep our social life safe comfortable. Some maintenance robots have already been developed; but all for medium or large sizes. No robots, which small size with inner diameter one inch less, developed. The authors thus trying develop a screw-principle microrobot,...
Background/Aim: Although direct oral anti - coagulants (DOACs) are as safe and effective conventional anticoagulants for treating venous thromboembolism (VTE), we have insufficient evidence justifying their use in patients with active cancer. We investigated the safety effectiveness of DOACs Patients Methods: To investigate efficacy DOACs, retrospectively extracted 312 consecutive cancer who were prescribed edoxaban, rivaroxaban or apixaban VTE. Results: The most common primary sites lung,...
Erlotinib plus gemcitabine is one of the standard chemotherapies for unresectable pancreatic cancer. Pancreatic cancer has highest frequency KRAS gene mutations among human cancers, and some studies suggest that status might be a predictive biomarker anti-epidermal growth factor receptor treatment. However, reliability this not been confirmed. Here, we evaluated impact in patients treated with first line gemcitabine-based chemotherapy. 23 chemotherapy whose could examined from primary or...
150 Background: The ATTRACTION-2 study showed that nivolumab is effective in treating advanced gastric cancer (AGC). Many studies have examined the effectiveness of predictive factors. We previously suggested neutrophil-to-lymphocyte ratio (NLR) was associated with progression-free survival (PFS) and overall survival. objective this to determine changes NLR for AGC treated nivolumab. Methods: Data on patients from November 2014 December 2017 were collected at two centers. NLRs calculated...
We herein report the first case in which an escalated dose of sunitinib was effective, even after reduction. A 64-year-old man with gastrointestinal stromal tumor small intestine discontinued adjuvant imatinib because interstitial pneumonia. After two years, peritoneal recurrence detected. Sunitinib started at 50 mg/day for 4 weeks every 6 weeks, dosage reduced to 37.5 grade 1 gastritis, stomatitis, and a fever. Four months later, computed tomography showed progressive disease. As adverse...
396 Background: Although nivolumab (NIVO) and irinotecan (IRI) are currently used as third- or later-line therapy for advanced gastric cancer (AGC), few direct comparisons between them have been available. The present study therefore aims to compare the efficacy safety of NIVO with IRI explore clinical factors that predict efficacy. Methods: Patients AGC who underwent treatment November 2016 June 2018 at three institution were retrospectively examined, subsequently evaluating response rates...
Introduction: Trifluridine/tipiracil (TAS-102) and Regorafenib (REG) have shown promising activity in patients with heavily pretreated metastatic colorectal cancer (mCRC). The aim of this study was to compare the efficacy safety TAS-102 REG alone mCRC refractory standard chemotherapies. Methods: From May 2014 December 2017, 135 were treated or as salvage-line therapy. Efficacy, clinical outcomes retrospectively evaluated. Inclusion criteria histologically confirmed adenocarcinoma; intolerant...
Introduction: The ATTRACTION-2 study showed that nivolumab is an effective treatment for advanced gastric cancer (AGC). Many studies have examined the effectiveness of predictive factors, such as programmed death ligand-1, mismatch repaired deficiency, and mutation burden. Several demonstrated neutrophil-to-lymphocyte ratio (NLR) a or prognostic factor lung treated with nivolumab. objective this was to determine NLR AGC monotherapy. Methods: This retrospective in single center we collected...
6552 Background: Today, the chemotherapy is performed in outpatient, but there no research on safety. This study aimed to determine safety of outpatients receiving and points note when they visit emergency room. Methods: We retrospectively collected data from July 2011 October 2018 tertiary referral center visited ER within 3 months administration chemotherapy. Results: Seven hundred thirty-four cases (345 patients) were enrolled (median age, 71 years; male 410, female 324). The median days...
e13019 Background: Since trastuzumab emtansine (T-DM1) was established as a standard treatment option, the strategy of metastatic HER2-positive breast cancer has markedly changed. However, clinical evidence regarding treatments beyond T-DM1 is insufficient. In this study, we attempted to describe real-world selection and efficacy following for cancer. Methods: This multi-center retrospective cohort study conducted in 17 hospitals Japan. Consecutive patients with who had received started...