A5101757225- Breast Cancer Treatment Studies
- Breast Lesions and Carcinomas
- HER2/EGFR in Cancer Research
- Cancer Treatment and Pharmacology
- Cancer-related cognitive impairment studies
- Tryptophan and brain disorders
- Advanced Breast Cancer Therapies
- Cancer Diagnosis and Treatment
- Cancer, Stress, Anesthesia, and Immune Response
- Multiple and Secondary Primary Cancers
- Peptidase Inhibition and Analysis
- Thyroid Cancer Diagnosis and Treatment
- Global Cancer Incidence and Screening
- Cancer and Skin Lesions
- Cancer survivorship and care
- Neuroscience and Neuropharmacology Research
- Anesthesia and Pain Management
- Cancer Genomics and Diagnostics
- Neuroendocrine Tumor Research Advances
- Cancer-related Molecular Pathways
- Cancer Cells and Metastasis
- S100 Proteins and Annexins
- Cancer Immunotherapy and Biomarkers
- Colorectal Cancer Treatments and Studies
- Genomic variations and chromosomal abnormalities
Japanese Foundation For Cancer Research
2020-2025
The Cancer Institute Hospital
2022
Nihon University
1990-2018
Ito Hospital
2017
Fujisawa City Hospital
2013-2015
ABSTRACT Background Patients with triple negative breast cancer (TNBC) who have a poor response to neoadjuvant chemotherapy (NAC) worse survival and new treatment strategies need be developed. TNBC is considered subtype in which the cyclic GMP‐AMP synthase (cGAS) linked stimulator of interferon genes (STING) pathway, an innate immune that recognizes cytosolic nucleic acid components, activated when DNA damage occurs, attracting attention as therapeutic target. Methods underwent surgery...
Although advanced thyroid carcinoma patients who cannot be cured by conventional therapy have lacked effective treatment, multitargeted tyrosine kinase inhibitors recently become available. Phase 3 trials of lenvatinib showed a median time to objective response 2 (95 % confidence interval (CI) 1.9-3.5) months, demonstrating that shrinks tumors rapidly. The phenomenon immediate tumor shrink is known as early shrinkage (ETS) which related clinical outcome in other malignancies. However,...
Background Neuromuscular monitoring using the corrugator supercilii muscle is associated with a number of challenges. The aim this study was to assess reversal rocuronium‐induced neuromuscular blockade sugammadex according either or adductor pollicis muscle. We hypothesized that larger dose would be required obtain train‐of‐four ( TOF ) ratio 1.0 than Methods Forty patients aged 20–60 years and 40 ≥ 70 were enrolled. After induction anesthesia, we recorded response facial nerve stimulation...
Abstract Background Trastuzumab emtansine (T-DM1) treatment for human epidermal growth factor receptor-2 (HER2)-positive metastatic breast cancer after taxane with trastuzumab and pertuzumab is standard therapy. However, strategies beyond T-DM1 are still in development insufficient evidence of their effectiveness. Here, we aimed to evaluate real-world choice efficacy treatments HER2-positive cancer. Methods In this multi-centre retrospective cohort study involving 17 hospitals, 325 female...
Abstract Background Li-Fraumeni syndrome (LFS), a hereditary condition attributed to TP53 pathogenic variants,(PV), is associated with high risks for various malignant tumors, including breast cancer. Notably, individuals harboring PVs are more likely (67–83%) develop HER2 + cancer than noncarriers (16–25%). In this retrospective study, we evaluated the associations between variants and phenotype. Methods We conducted review of medical records patients LFS treated at single institution...
MUC1 glycoprotein is overexpressed and its intracellular localization altered during breast carcinoma tumorigenesis. The present study aimed to clarify the relationship of cytoplasmic with cancer subtype correlation 10 molecules associated cell polarity in subtypes. We immunostained 131 formalin-fixed paraffin-embedded specimens an anti-MUC1 antibody (MUC1/CORE). For 48 tumor specimens, laser-assisted microdissection real-time quantitative RT-PCR were performed analyze mRNA levels molecules,...
Abstract Background Trastuzumab and fulvestrant combination therapy is one of the treatment options for patients with hormone receptor- human epidermal growth factor receptor 2 (HER2)-positive metastatic breast cancer; however, there are limited studies evaluating efficacy this therapy. Methods We retrospectively reviewed data women HER2-positive cancer who received trastuzumab between August 1997 2020 at Cancer Institute Hospital. The primary endpoint study was progression-free survival,...
We previously demonstrated the occurrence of cellular swelling during cerebral ischemia in vivo using microdialysis. 14C-Sucrose was pre-perfused into extracellular space (ECS) as an ECS marker, and detected increase concentration 14C-sucrose. In present study, we examined rats time courses FFA relation to swelling, role excitatory amino acids (EAAs) these events. A pair microdialysis probes were placed hippocampus bilaterally. One probe perfused with modified Ringer solution containing...