Soft liner materials in oral cavity environments are easily colonized both by fungi and dental plaque. These factors the cause of mucosal infections. The microorganism that most frequently colonizes soft is Candida albicans. Colonization occurs on surface within materials. A solution to this problem might involve modification with silver nanoparticles (AgNPs). In article, we present results showing antifungal efficacy silicone lining modified AgNPs. process was conducted dissolving material...

Prostate cancer is a commonly diagnosed in men. The ethanolic extract of propolis (EEP) and its phenolic compounds possess immunomodulatory, chemopreventive antitumor effects. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL/APO2L) naturally occurring anticancer agent that preferentially induces apoptosis cells not toxic to normal cells. We examined the cytotoxic apoptotic effects EEP isolated from combination with TRAIL on two prostate cell lines, hormone-sensitivity LNCaP...

The aim of this study was to investigate the chemical composition and anti-inflammatory effect ethanolic extract Brazilian green propolis (EEP-B) on LPS + IFN- γ or PMA stimulated J774A.1 macrophages. identification quantification phenolic compounds in were performed using HPLC-DAD UPLC-Q-TOF-MS methods. cell viability evaluated by MTT LDH assays. radical scavenging ability determined DPPH • ABTS •+ . ROS RNS generation analyzed chemiluminescence. NO concentration detected Griess reaction....

The aim of this study was to evaluate the activity fluconazole against 32 clinical strains fluconazole-resistant Candida albicans , and C. ATCC 10231 reference strain, after their exposure sublethal concentrations tea tree oil (TTO) or its main bioactive component terpinen-4-ol. For all tested TTO terpinen-4-ol minimal inhibitory (MICs) were low, ranging from 0.06% 0.5%. 24-hour with dose enhanced these strains. Overall, 62.5% isolates classified as susceptible, 25.0% exhibited intermediate...

Background/Objectives: Plaque-associated gingivitis is widely regarded as a local inflammatory condition initiated by the accumulation of non-specific dental biofilm in interaction with host immune system. The initial symptom noticed patient bleeding gums. use mouthwash can serve to supplement mechanotherapy. However, there an increasing interest mouthwashes comprising natural ingredients, including cannabidiol (CBD) and spilanthol. objective this study was evaluate effect oral rinse...

Propolis-based therapeutic agents represent this potential for the development of new drugs in dental care. The aim a clinical-cohort study was to determine influence application toothpaste enriched with Brazilian extract propolis (EEP) on health status oral cavity. Laboratory analysis conducted order assess chemical composition EEP including total phenolic compounds, DPPH (1,1-diphenyl-2-picrylhydrazyl) radical scavenging activity, ABTS cation and FRAP assay. Clinical research involved two...

Betulin derivatives containing a 1,2,3-triazole ring possess wide spectrum of biological activities, including antiviral, anticancer, and antibacterial activity. A series novel triazoles were prepared by the 1,3-dipolar cycloaddition reaction between alkyne betulin organic azides. The chemical structures obtained compounds defined ¹H 13C NMR, IR, high-resolution mass spectrometry (HR-MS) analysis. target screened for their antiviral activity against DNA RNA viruses. cytotoxic 5a-k 6a-h was...

The soft and periodontal tissues surrounding dental implants are particularly susceptible to bacteria invasion inflammatory reactions due complex histological structures. This study was carried out investigate the influence of a propolis-containing hygienic agent on selected oral health parameters, microflora, condition health. Sixteen subjects who underwent an rehabilitation with were randomly assigned into two groups, which received newly formulated toothpaste (3% (CA)) or negative control...

Secondary caries is one of the important issues related to using dental composite restorations. Effective prevention cariogenic bacteria survival may reduce this problem. The aim study was evaluate antibacterial activity and physical properties materials with silver sodium hydrogen zirconium phosphate (SSHZP). filler introduced at concentrations 1%, 4%, 7%, 10%, 13%, 16% (w/w) into model material consisting methacrylate monomers silanized glass silica fillers. in vitro reduction number...

Artepillin C (3,5-diprenyl-4-hydroxycinnamic acid) is the main bioactive component of Brazilian green propolis. The aim this study was to investigate anti-inflammatory effect artepillin on LPS + IFN- γ - or PMA-stimulated RAW264.7 macrophages. cell viability evaluated by MTT and LDH assays. radical scavenging ability determined using DPPH(•) ABTS(•+). ROS RNS generation analyzed chemiluminescence. NO concentration detected Griess reaction. release various cytokines activated cells measured...

TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) is an endogenous ligand, which plays role in immune surveillance and anti-tumor immunity. It has ability to selectively kill tumor cells showing no toxicity normal cells. We tested the apoptotic cytotoxic activities of xanthohumol, a prenylated chalcone found Humulus lupulus on androgen-sensitive human prostate adenocarcinoma (LNCaP) combination with TRAIL. Cytotoxicity was measured by...

Maintenance of proper oral hygiene by dental plaque elimination is one the most important factors affecting healing process in postoperative wounds. Propolis a substance produced bees. Ethanolic extract propolis has bactericidal, fungicidal, anti-inflammatory, and antioxidative properties. Moreover, it can scavenge free radicals. The purpose this paper to demonstrate efficacy gel containing 3% ethanolic Brazilian green (EEP-B) when used for maintaining patients with mucosal was assessed...

A significant problem related to the functioning of resin-based composites for dental fillings is secondary or recurrent caries, which reason need repeated treatment. The cross-linked quaternary ammonium polyethylenimine nanoparticles (QA-PEI-NPs) have been shown be a promising antibacterial agent against different bacteria, including cariogenic ones. However, little known about properties dimethacrylate polymer-based enriched with QA-PEI-NPs. This research was carried out on experimental...

Few reports have been published on the early microbiota in infants with various types of cleft palate. We assessed formation oral complete lip and palate (CLP n = 30) or soft (CSP 25) neonatal period (T1 time) again gum pad stage (T2 time). Culture swabs from tongue, palate, and/or margin at T1 T2 were taken. analysed prevalence given bacterial species (the percentage) proportions which tongue colonised by each microorganism. At T1, Streptococcus mitis (S. mitis) most frequently detected...

The study was based on the use of a toothpaste with antiphlogistic activity, containing Australian Melaleuca alternifolia oil (tea tree oil-TTO) and ethanolic extract Polish propolis (EEP). Fifty-one patients varying conditions gingiva were divided into two groups. group received TTO EEP, while control same but without EEP. Approximal plaque index (API), simplified oral hygiene (OHI-s) modified sulcus bleeding (mSBI) assessed in three subsequent stages. During each examination, swabs...

The aim of this study was to evaluate the effect toothpaste containing natural tea tree essential oil (TTO) and ethanolic extract propolis (EEP), on microflora selected indicators oral health in patients using removable acrylic partial dentures. Fifty with varying conditions hygiene were divided into two groups. group received TTO EEP, while control same but without EEP. At first visit, prostheses carried out. Control visits took place 7 28 days later compared baseline. Indexes like API...

The anti-inflammatory and antibacterial action of preparations used during oral hygiene procedures is particularly important in patients with cleft. Few reports have been published assessing the influence natural products on state cavity aim this study was to assess effect toothpaste containing Polish propolis plant oils health cleft treated orthodontically. A total 50 aged 9–16 years old (20 females, 23 males) were selected randomly assigned into two groups. Group (A) received propolis, tea...

Colonization of temporary denture soft linings and underlying tissues by yeast-like fungi is an important clinical problem due to the negative influence on process prosthetic treatment. Typical hygienic procedures are often insufficient prevent fungal infections, so in this study, antimicrobial filler (silver sodium hydrogen zirconium phosphate) was introduced into acrylic liner at concentrations 1, 2, 4, 6, 8 10% (w/w). The effect modification antifungal properties against Candida albicans,...

The colonizing of temporary soft lining materials in the oral cavity by yeast-like fungi, particularly Candida albicans, poses a significant risk complications during prosthetic treatment. Various experimental incorporating antimicrobial additives, such as drugs, natural oils, and inorganic particles, have been tested. However, these components are not chemically bonded to polymer network, making them prone being easily released into surrounding environment. This study aimed evaluate...

Synthetic polymers belonging to the aliphatic polyester group have become highly promising biomaterials for reconstructive medicine. The purpose of present work is a biological evaluation lactide-glycolide co-polymer (PLGA) and its composites with carbon fibers (PLGA+CF) or hydroxyapatite (PLGA+HA). cytotoxicity evaluated materials towards hFOB 1.19 human osteoblast-like cells was assessed. Moreover, during one-year contact assessed living osseous tissue, progress bone formation analyzed...

The aim of this study was to evaluate the influence 3% ethanol extract propolis (EEP) on hygiene, gingival and microbiological status oral cavity in patients with cleft lip palate treated fixed orthodontic appliances. included forty-one nonsyndromic complete unilateral bilateral subjects appliance at least 10 teeth. Twenty-one were instructed brush their teeth three times a day using toothpaste propolis. Control group twenty who asked without API, OPI, GI, supragingival bacterial plaque...

The colonization of poly(methyl methacrylate) (PMMA) denture base materials by pathogenic microorganisms is a major problem associated with the use prostheses, and incorporation antimicrobial fillers method improving properties these materials. Numerous studies have demonstrated initial in vitro effectiveness this type material; however, reports demonstrating stability over longer periods are not available. In study, silver sodium hydrogen zirconium phosphate was introduced into powder...

The aim of this study was to investigate the influence a topically administered hygienic preparation containing 3% ethanolic extract Brazilian green propolis (EEP-B) on oral microflora spectrum changes in group patients who underwent common surgery procedures. Two gel samples were compared: tested an active ingredient, that is, EEP-B (gel GA), and placebo as negative control GC). collection microbiological material included 14 requiring surgical extraction wisdom molars short endosseous...