A5016274180- Analytical chemistry methods development
- Renal Diseases and Glomerulopathies
- Electrochemical Analysis and Applications
- Electrolyte and hormonal disorders
- Renal Transplantation Outcomes and Treatments
- Industrial Vision Systems and Defect Detection
- Parvovirus B19 Infection Studies
- Liver Disease and Transplantation
- Extraction and Separation Processes
- Analytical Chemistry and Sensors
- Polyomavirus and related diseases
- Viral gastroenteritis research and epidemiology
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Radioactive element chemistry and processing
- Animal Virus Infections Studies
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Renal cell carcinoma treatment
- Advanced Operator Algebra Research
- Drug Transport and Resistance Mechanisms
- Hepatitis Viruses Studies and Epidemiology
- Water Quality Monitoring and Analysis
- Advanced Topics in Algebra
- Ultrasonics and Acoustic Wave Propagation
- Enzyme Structure and Function
- Cholesterol and Lipid Metabolism
Ministry of the Environment
2025
Indiana University – Purdue University Indianapolis
2016-2024
Fujitsu (China)
2023-2024
Kyoto University
2016-2024
Fujitsu (United States)
2021-2024
JES & Co
2023
Hitachi (Japan)
1976-2020
Kyoto University Hospital
2016-2020
University of Michigan
2019
Hitachi (United Kingdom)
2017
It has been shown recently that immunotherapy for advanced melanoma is effective. However, in order to improve the efficacy of immunotherapy, identification more specific melanoma-associated antigens urgently needed. Kinesin family member 20A (KIF20A) reported be a promising immunotherapeutic target pancreatic cancer. To investigate expression KIF20A melanoma, we performed quantitative reverse transcript (RT)-PCR and western blotting analyses cell lines. We also investigated primary...
Background and objectives Human hepatitis E virus ( HEV ) is prevalent worldwide. Iatrogenic has recently been identified based on the reports of transfusion‐transmitted cases. The detection rate ‐ RNA seroprevalence ‐IgG/IgM have regionally evaluated in Japan, donor plasma collected Hokkaido currently screened by nucleic acid amplification testing. However, blood donors Japan outside not reported. Materials Methods A total 620 140 qualified samples from Japanese regions excluding were...
We assessed the utility of two forms osteopontin (OPN), OPN full and its cleaved form (OPN N-half), in plasma urine as markers disease activity lupus nephritis (LN). Samples were collected from patients with systemic erythematosus (SLE) (LN: N = 29, non-LN: 27), IgA nephropathy (IgAN) (N 14), minimal change nephrotic syndrome (MCNS) 5), diabetic (DN) 14) healthy volunteers (HC) 17). While there was no significant difference concentration between groups, N-half significantly higher LN than HC...
Nitric oxide is synthesized in diverse mammalian tissues by a family of calmodulin-dependent nitric synthases (NOS). Caveolin, the principal structural protein caveolae, interacts with endothelial NOS (eNOS) leading to enzyme inhibition reversible process modulated Ca++ -calmodulin. The aim present study was examine localizations eNOS and caveolin-1 at level normal human liver tissue, how expressions are altered cirrhotic liver.Fresh specimens were obtained from hepatic surgeries. Normal...
The antibiotic concanamycin B was found to inhibit oxidized‐low‐density‐lipoprotein(LDL)‐induced accumulation of lipid droplets in the macrophage J774 at a concentration 5–10 nM. Concanamycin inhibited cholesteryl‐ester synthesis from [ 14 C]oleate by 50% nM without affecting triacylglycerol and polar lipids. Degradation internalized oxidized 125 I‐LDL about 80% cells treated with 25 B, while cell‐surface binding 4°C, uptake surface‐bound microsomal acyl‐CoA: cholesterol acyltransferase...
Abstract Virus filtration with nanometer size exclusion membranes (“nanofiltration”) is effective for removing infectious agents from biopharmaceuticals. While the virus removal capability of filters typically evaluated based on calculation logarithmic reduction value (LRV) infectivity, knowledge exact mechanism(s) retention remains limited. Here, human parvovirus B19 (B19V), a small (18–26 nm), was spiked into therapeutic plasma protein solutions and filtered through Planova™ 15N 20N in...
A defect in TCR-proximal signaling is a major characteristic of CD4 T cells systemic lupus erythematosus; however, it not fully known how defects TCR lead to lupus-like autoimmunity characterized by germinal center development and autoantibody production against nuclear Ags. In this study, we show that SKG mice, which develop autoimmune arthritis BALB/c background due defective Zap70 mutation, disease the C57BL/6 (B6) (B6SKG mice). B6SKG mice showed multiorgan inflammation with immune...
A number of peptides with different lengths corresponding to various regions human pulmonary surfactant protein SP-C were synthesized and their activity evaluated improve in vitro surface activities situ lung pressure-volume characteristics a ternary lipid mixture composed dipalmitoylphosphatidylcholine, phosphatidylglycerol palmitic acid (75:25:10, w/w). (1-35), synthetic peptide the entire length SP-C, some other its partial sequences remarkably active. All these shared common core...