A5006109788- Protease and Inhibitor Mechanisms
- Eicosanoids and Hypertension Pharmacology
- Plant biochemistry and biosynthesis
- Microbial Metabolism and Applications
- Acute Ischemic Stroke Management
- Cholesterol and Lipid Metabolism
- Peptidase Inhibition and Analysis
- Signaling Pathways in Disease
- Antiplatelet Therapy and Cardiovascular Diseases
- Microbial Natural Products and Biosynthesis
- Steroid Chemistry and Biochemistry
- S100 Proteins and Annexins
- Peroxisome Proliferator-Activated Receptors
- Enzyme Production and Characterization
- Biochemical and Structural Characterization
- Inflammatory mediators and NSAID effects
- Traditional and Medicinal Uses of Annonaceae
- Natural product bioactivities and synthesis
- Blood Coagulation and Thrombosis Mechanisms
- Cancer, Hypoxia, and Metabolism
- Marine Sponges and Natural Products
- Neurological Disorders and Treatments
- Drug Transport and Resistance Mechanisms
- Pharmacological Effects of Natural Compounds
- Alcohol Consumption and Health Effects
Tokyo University of Agriculture and Technology
2015-2025
Ryukoku University
2009-2020
Institute of Science Tokyo
1998-2020
Showa University
2011
The Cancer Institute Hospital
2007
Teikyo University
2004
Tokyo Institute of Technology
1998-2001
Hitachi (Japan)
1986-2000
Tokyo Electron (Japan)
1986-2000
Case Western Reserve University
1975
Polyoxomolybdates (PMs) as discrete molybdenum-oxide cluster anions have been investigated in the course of study their medical applications. Here, we show significant antitumour potency polyoxomolybdate [Me3NH]6[H2MoV12O28(OH)12(MoVIO3)4]·2H2O (PM-17), which is a photo-reduced compound [NH3Pri]6[Mo7O24]·3H2O. The effect PM-17 on growth cancer cell lines and xenografts was assessed by viability test analysis tumour expansion rate. Morphological carried out Hoechst staining, flow-cytometric...
Mulberry leaves are rich in 1-deoxynojirimycin (DNJ), an inhibitor of α-glucosidase. We previously showed that DNJ-rich mulberry leaf extract suppressed elevation postprandial blood glucose humans. The objective this study was to evaluate the effects on plasma lipid profiles An open-label, single-group conducted 10 subjects with initial serum triglyceride (TG) level ≥200 mg/dl. Subjects ingested capsules containing at 12 mg three times daily before meals for weeks. Our findings a modest...
Thrombolysis therapy using tissue-type plasminogen activator (t-PA) is occasionally accompanied by harmful outcomes, including intracerebral hemorrhage. We have reported that Stachybotrys microspora triprenyl phenol-7 (SMTP-7), a candidate thrombolytic drug, has excellent therapeutic effect on cerebral infarction in embolic stroke model mice; however, little known regarding whether this agent influences cerebrovascular inflammation following reperfusion. The current study aimed to compare...
SMTP-7 ( Stachybotrys microspora triprenyl phenol-7), a small molecule that promotes plasminogen activation through the modulation of conformation, has excellent therapeutic activity against cerebral infarction in several rodent models. Detailed evaluations primate stroke model are needed for effective, safe drug development. Here we evaluated monkey photochemical-induced thrombotic middle artery (MCA) occlusion n=6), which MCA was followed by recanalization/reocclusion. (10 mg/kg,...
Although ischemic stroke is a major cause of death and disability worldwide, only small fraction patients benefit from the current thrombolytic therapy due to risk cerebral hemorrhage caused by inflammation. Thus, development new strategy combat inflammation during thrombolysis an urgent demand. The molecule SMTP-7 effectively treats in several animal models with reducing hemorrhage. Here we revealed that targeted soluble epoxide hydrolase (sEH) suppress inhibited both two sEH enzyme...
Tissue plasminogen activator (t-PA) has a short therapeutic time window for administration (3 h) and carries risk of promoting intracerebral hemorrhage. The aim the present study was to investigate frequency hemorrhagic region by treatment with Stachybotrys microspora triprenyl phenol-7 (SMTP-7). Thrombotic occlusion induced transfer acetic acid-induced thrombus at right common carotid artery into brain mice. Infarction area, neurological score, edema percentage, regional cerebral blood flow...
Introduction: Approved thrombolytic agents are currently only recommended for acute ischemic stroke (AIS) within 4.5 hours from the last known well (LKW). Hence, there remains an unmet need in treatment of AIS safer and more effective thrombolytics, which can also be administered to a broader population with extended window. JX10 is novel that works by inducing conformational changes plasminogen increase downstream fibrin affinity promote physiological fibrinolysis instead direct activation...
The antibiotic concanamycin B was found to inhibit oxidized‐low‐density‐lipoprotein(LDL)‐induced accumulation of lipid droplets in the macrophage J774 at a concentration 5–10 nM. Concanamycin inhibited cholesteryl‐ester synthesis from [ 14 C]oleate by 50% nM without affecting triacylglycerol and polar lipids. Degradation internalized oxidized 125 I‐LDL about 80% cells treated with 25 B, while cell‐surface binding 4°C, uptake surface‐bound microsomal acyl‐CoA: cholesterol acyltransferase...