A5086594236- Cancer-related molecular mechanisms research
- Allergic Rhinitis and Sensitization
- Gastric Cancer Management and Outcomes
- Pharmacological Effects of Natural Compounds
- Dysphagia Assessment and Management
- Helicobacter pylori-related gastroenterology studies
- Natural product bioactivities and synthesis
- Traditional Chinese Medicine Analysis
- Plant-based Medicinal Research
- Obstructive Sleep Apnea Research
- Sinusitis and nasal conditions
- Nasal Surgery and Airway Studies
- Cancer, Lipids, and Metabolism
- Infant Nutrition and Health
- Head and Neck Surgical Oncology
- Otolaryngology and Infectious Diseases
- Dermatology and Skin Diseases
- Cancer survivorship and care
- Mycobacterium research and diagnosis
- Medicinal Plants and Bioactive Compounds
- Complementary and Alternative Medicine Studies
- Respiratory and Cough-Related Research
- Breastfeeding Practices and Influences
- Eosinophilic Esophagitis
- Reproductive Health and Contraception
Chang Gung University
2020-2024
Chiayi Chang Gung Memorial Hospital
2015-2024
Weatherford College
2021
Memorial Hospital of South Bend
2015
Danshen (salvia miltiorrhiza Bunge) is widely used in traditional Chinese medicine. However, it definite clinical effort and mechanism on breast cancer unclear. In our study, we the real-world database to investigate vivo protective of danshen patients through using population-based data from Taiwan National Health Insurance Research Database (NHIRD). vitro, human cells (MCF-7 MDA-MB-231 cells) were effect underlying XTT assay, flow cytometry, glutathione peroxidase (GPX) activity GSH...
Breast cancer is the most common in women and affects 1.38 million worldwide per year. Antiestrogens such as tamoxifen, a selective estrogen receptor (ER) modulator, are widely used clinics to treat ER-positive breast tumors. However, remissions of often followed by resistance tamoxifen disease relapse. Despite increasing understanding mechanisms, effective regimens for treating tamoxifen-resistant limited. Antrodia cinnamomea traditional medicinal mushroom native only Taiwan. In this study,...
Chinese herbal products (CHPs) have been frequently used among patients with chronic diseases including hypertension; however, the co-prescription pattern of formulae and single herbs remain uncharacterized. Thus, this large-scale pharmacoepidemiological study evaluated frequency CHPs for treating hypertension in Taiwan from 2003 to 2009.The database traditional medicine (TCM) outpatient claims was obtained National Health Insurance Taiwan. Patients during period were defined according...
Background: Numerous studies have revealed that statins antitumor effects in vivo and vitro. However, few explored the relationship between statin use mortality of gastric cancer (GC) patients after treatments. This study examines overall survival (OS) GC surgery adjuvant chemotherapy, using data from nationwide cohort database Taiwan. Methods: All newly diagnosed with 1999 to 2008 Taiwan were identified Registry Catastrophic Illness Patients Database. Through propensity score matching,...
Glycyrrhiza glabra, a family of licorice and traditional Chinese medicine with sweet taste favorable smell, has anti-inflammatory, anti-allergic immunomodulatory functions. Aim the study: We developed extract (LE) by using glycyrrhiza glabra administered it through nasal irrigation to treat allergic rhinitis (AR). LE was prepared into powder, anti-inflammatory effect evaluated calcium ionophore-induced activated mast cell model (in vitro). Then, local passive anaphylaxis assays were applied...
Background. Gastric cancer remains a major globally. More than half of patients with gastric undergo surgery in Taiwan; however, few large nationwide studies have investigated the effects traditional Chinese medicine (TCM) on management after surgery. This study aimed to evaluate effect TCM following and adjuvant chemotherapy Taiwan its prescription trends. Methods Materials. The cohort sampling data set was obtained from Registry Catastrophic Illness Patient Database, research database...
Background: Mastitis is a common disorder among postpartum women. The discomfort and pain caused by mastitis may lead to the discontinuation of breastfeeding. Large-scale epidemiological studies examining are limited. Accordingly, present study used nationwide population-based database collect information about all women in Taiwan determine incidence related factors for mastitis. Materials Methods: This retrospective National Health Insurance Research Database records patients with during...
To date, treating nasal polyps (NPs) is still a medical challenge. However, we have developed an innovative therapy using licorice extract (LE: Glycyrrhiza glabra) to treat rhinitis and sinusitis via irrigation discovered that it significantly affects treatment of NPs.This study investigated the mechanism LE on NPs.NPs were collected from three patients tissue biopsies before 2 weeks after with for histopathological analysis. Additionally, NPs two collected, polyp-derived fibroblasts (NPDF)...
The Chiehyuan herbal oral protection solution (GB-2) is a mixture commonly utilized in Taiwan for combating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) as per traditional Chinese medicine practices. This study assessed the clinical impact of GB-2 through prospective trials. With twice-daily use week, was shown to diminish expression angiotensin-converting enzyme (ACE2) mucosal cells. Moreover, after two weeks use, it could reduce transmembrane protease, serine (TMRPSS2)...
Allergic rhinitis (AR) is correlated with diseases including allergic laryngitis, chronic obstructive pulmonary disease (COPD), asthma, and rhinosinusitis (CRS). The unified airway model suggests that inflammation can spread in both lower upper respiratory tracts. Moreover, some voice problems—laryngeal edema, dysphonia, vocal nodules—have been associated AR. We examined the association between AR laryngeal pathology. investigated 51,618 patients 1 January 1997 31 December 2013, along...
(1) Background: Sleep apnea may be a risk factor for deep neck infection (DNI). The objective of this study was to investigate the effects sleep on DNI. (2) Methods: In first nationwide retrospective cohort apnea–DNI correlation, we obtained data from Longitudinal Health Insurance Database 2005, subset Taiwan National Research Database. Patients who were newly diagnosed with between 1997 and 2012 identified, patients without matched at 1:4 ratio in age, sex, socioeconomic status,...
Abstract Objective The association between gastroesophageal reflux disease (GERD) and laryngeal disorders remains debatable, although it has been the focus of extensive clinical laboratory research. We conducted this study to obtain evidence on association. Study Design Population‐based cohort study. Setting Taiwan National Health Insurance Research Database (NHIRD). Methods Using data from Taiwan's NHIRD (January 2000 December 2018), we performed a population‐based analysis estimate risk in...
<title>Abstract</title> Background Traditional Chinese medicine (TCM) is widely applied in assisted reproductive technology (ART). However, TCM drug utilization and prescription patterns reproduction remain unclear. This study was conducted to analyze these patterns. Methods Using data from Taiwan’s Artificial Reproductive Database National Health Insurance Research Database, we analyzed the frequency of prescriptions proportions which different herbal formulae individual herbs were...
Vocal fold nodules (VFNs) are the most frequent cause of hoarseness. The management comprised medical, surgical and physical therapy but effectiveness is not always satisfactory. In this study, we try to figure out an alternative treatment from our clinical experience summary. We retrospectively reviewed VFNs patients who received traditional Chinese medicine (TCM) treatments July 2018 August 2020 traced their Voice Handicap Index-10 (VHI-C10) multidimensional voice program (MDVP) analysis...
Chronic rhinosinusitis (CRS) affects the quality of life many people worldwide and can cause comorbidities. Our previous research proved that Sjogren's syndrome (SS) is a predisposing factor for CRS, with 2.5-fold associated risk. Antibiotics are important in CRS treatment; however, there paucity on pathogenic bacteria SS-CRS past. We conducted this study to investigate difference non-SS-CRS aimed give clinicians references when selecting antibiotics treat SS-CRS.A total 14,678 patients...
To determine whether exposure to antidepressants (ATDs) results in improved overall survival (OS) of patients with gastric cancer (GC) after surgery, we conducted a large cohort study and considered confounding factors that might affect the research outcomes.Patients who received new diagnosis GC surgery chemotherapy between 1999 2008 were recruited classified into different groups based on ATD level used. The association OS levels use, hazard ratio comorbidities at use compared.According...
Abstract Background: Vocal fold nodules (VFN) are one of the main causes hoarseness. In this study, we try to figure out an alternative treatment from our clinical experience summary. Methods: We retrospectively reviewed VFN patients who received traditional Chinese medicine (TCM) treatments July 2018 August 2020 and traced their Voice Handicap Index-10 (VHI-C10) multidimensional voice program (MDVP) analysis results. Also, induce inflammatory response porcine vocal epithelial (PVFE) cells...