A5040240835- Peroxisome Proliferator-Activated Receptors
- Microbial Natural Products and Biosynthesis
- Cancer therapeutics and mechanisms
- Cholesterol and Lipid Metabolism
- Drug Transport and Resistance Mechanisms
- Tuberculosis Research and Epidemiology
- Cardiac Health and Mental Health
- Inflammatory mediators and NSAID effects
- Cardiovascular and exercise physiology
- Natural product bioactivities and synthesis
- RNA and protein synthesis mechanisms
- Bioactive Compounds and Antitumor Agents
- Atherosclerosis and Cardiovascular Diseases
- Cardiovascular Function and Risk Factors
- Chemical Synthesis and Analysis
- Anesthesia and Neurotoxicity Research
- Eicosanoids and Hypertension Pharmacology
- Synthesis and bioactivity of alkaloids
- Pharmacogenetics and Drug Metabolism
- Geomagnetism and Paleomagnetism Studies
- Heart Failure Treatment and Management
- Calcium signaling and nucleotide metabolism
- Bacterial Genetics and Biotechnology
- Animal Nutrition and Physiology
- Pneumocystis jirovecii pneumonia detection and treatment
China Tobacco
2025
Duke Medical Center
2024
Guangdong Provincial Hospital of Traditional Chinese Medicine
2006-2024
Guangzhou University of Chinese Medicine
2024
North Sichuan Medical University
2024
Duke University Hospital
2024
China Agricultural University
2007-2024
The Affiliated Yongchuan Hospital of Chongqing Medical University
2024
Chongqing Medical University
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2011-2023
Diminished apoptosis, a critical event in tumorigenesis, is linked to down-regulated 15-lipoxygenase-1 (15-LOX-1) expression colorectal cancer cells. 13-S-hydroxyoctadecadienoic acid (13-S-HODE), which the primary product of 15-LOX-1 metabolism linoleic acid, restores apoptosis. Nonsteroidal antiinflammatory drugs (NSAIDs) transcriptionally up-regulate induce Peroxisome proliferator-activated receptors (PPARs) are nuclear for and arachidonic metabolites. PPAR-delta promotes colonic...
Abstract Bacterial magnetosomes (BMs) are commonly used as vehicles for certain enzymes, nucleic acids and antibodies, although they have never been considered drug carriers. To evaluate the clinical potential of BMs extracted from Magnetospirillum gryphiswaldense in cancer therapy, doxorubicin (DOX) was loaded onto purified at a ratio 0.87 ± 0.08 mg/mg using glutaraldehyde. The DOX‐coupled (DBMs) exhibited uniform sizes morphology evaluated by TEM. diameters DBMs obtained AFM were 71.02...
The beta-carboline alkaloids present in medicinal plants, such as Peganum harmala and Eurycoma longifolia, have recently drawn attention due to their antitumor activities. Further mechanistic studies indicate that derivatives inhibit DNA topoisomerases interfere with synthesis. Moreover, some compounds are specific inhibitors of cyclin dependent kinases (CDKs). In this study we used budding yeast a model system investigate the mechanism drugs. We found DH334, derivative, inhibits growth...
A better way to treat complex diseases such as cancer is aim for several targets at once. Beta-carboline derivatives have been shown anticancer activity, but these compounds may target enzymes required cell division. Polo-like kinases (PLKs) are well conserved serine/threonine and PLK1 plays multiple roles in proliferation. Thus, one of the attractive mitotic drugs. We found that DH166, a beta-carboline derivative, inhibits growth cdc5-2 temperature-sensitive mutant more profoundly than...
Tuberculosis is a serious global health problem. Its paradigms are shifting through time, especially in rapidly developing countries such as China. Health providers China at the forefront of battle against tuberculosis; however, there few empirical studies on providers' perspectives challenges they face tuberculosis control county level This study was conducted among to explore their experiences with order identify bottlenecks and emerging controlling rural China.A qualitative approach used....
Abstract Aurora kinases have emerged as promising targets for cancer therapy because of their critical role in mitosis. These are well-conserved all eukaryotes, and IPL1 gene encodes the single kinase budding yeast. In a virtual screening attempt, 22 compounds were identified from nearly 15,000 microbial natural products potential small-molecular inhibitors human Aurora-B kinase. One compound, Jadomycin B, inhibits growth ipl1-321 temperature-sensitive mutant more dramatically than wild-type...
Capreomycin is a second-line drug for multiple-drug-resistant tuberculosis (TB). However, with increased use in clinics, the therapeutic efficiency of capreomycin decreasing. To better understand TB resistance to capreomycin, we have done research identify molecular target capreomycin. Mycobacterium ribosomal proteins L12 and L10 interact each other constitute stalk 50S subunit, which recruits initiation elongation factors during translation. Hence, L12-L10 interaction considered be...
The ATP-binding cassette transporter A1 (ABCA1) is a membrane that directly contributes to high-density lipoprotein (HDL) biogenesis by mediating the cellular efflux of cholesterol and phospholipids lipid-poor apolipoprotein A-I.Therefore, identification novel upregulator ABCA1 would be beneficial for atherosclerosis prevention and/or therapy because its pivotal role in homeostasis HDL metabolism.In this study, high-throughput assay method upregulators was developed used screening synthetic...
Chronic alcohol users often exhibit an increased minimum alveolar concentration (MAC) of sevoflurane, yet the specific mechanism remains unclear. It has been reported that ethanol exposure can upregulate protein expression and enzyme activity cytochrome P450 2E1 (CYP2E1). CYP2E1 is a key converts 2-5% sevoflurane into equimolar amounts hexafluoroisopropanol (HFIP) F
Mycobacterium tuberculosis kills about 2 million people annually and antibiotic resistance is a cause of increased mortality. Therefore, development new antituberculosis drugs urgent for the control widespread infections. For this purpose, we performed an innovative screen to identify agents that disrupt function ribosomes in M. . Two bacterial ribosomal proteins L12 L10 interact with each other constitute stalk 50S subunit, which recruits initiation elongation factors (EFs) during...
Abstract Objectives Drug-resistant Mycobacterium tuberculosis poses a great threat to human health. Tyrosyl-tRNA synthetase (TyrRS) is one of the aminoacyl tRNA synthetases that catalyse attachment amino acids their cognate tRNAs and are essential for protein synthesis. There several distinctive differences between bacterial TyrRS therefore it could be potential target developing antimicrobial agents. This study aimed identify new anti-TB agent targeting M. (MtTyrRS). Methods We first used...
We report the identification and characterization of a new ischemia/reperfusion-inducible protein (IRIP), which belongs to SUA5/YrdC/YciO family. IRIP cDNA was isolated in differential display analysis an ischemia/reperfusion-treated kidney RNA sample. Mouse mRNA expressed all tissues tested, highest level being testis, secretory, endocrine organs. Besides ischemia/reperfusion, endotoxemia also activated expression liver, lung, spleen. The transporter regulator RS1 identified as...
Abstract Background C-1027, produced by Streptomyces globisporus is one of the most potent antitumoral agents. The biosynthetic gene cluster previously cloned and sequenced, contains at least three putative regulatory genes, i.e. sgcR1 , sgcR2 sgcR3 . predicted products these genes share sequence similarities to StrR, regulators AraC/XylS family TylR. purpose this study was investigate role in C-1027 biosynthesis. Results Overexpression S. resulted a 30–40% increase production. Consistent...