A5010478003- Saffron Plant Research Studies
- Research in Cotton Cultivation
- Endoplasmic Reticulum Stress and Disease
- Molecular Biology Techniques and Applications
- Plant-Microbe Interactions and Immunity
- Genetic and phenotypic traits in livestock
- Cancer-related molecular mechanisms research
- Genomics and Phylogenetic Studies
- Heat shock proteins research
- Nanoparticles: synthesis and applications
- Insect Pest Control Strategies
- Phytochemical and Pharmacological Studies
- Genetics and Plant Breeding
- Neurobiology and Insect Physiology Research
- Natural Products and Biological Research
- Cocoa and Sweet Potato Agronomy
- Essential Oils and Antimicrobial Activity
- Cancer therapeutics and mechanisms
- Advanced Glycation End Products research
- Ion Transport and Channel Regulation
- Redox biology and oxidative stress
- Genomics, phytochemicals, and oxidative stress
- Synthesis and bioactivity of alkaloids
- Bioactive Compounds and Antitumor Agents
- Nuts composition and effects
Scripps Research Institute
2025
Cotton Research Institute
2021-2024
Chinese Academy of Agricultural Sciences
2016-2024
Beijing Botanical Garden
2024
Institute of Botany
2024
University of Chinese Academy of Sciences
2024
Scripps (United States)
2024
Scripps Institution of Oceanography
2024
Ministry of Agriculture and Rural Affairs
2022
Institute of Special Animal and Plant Sciences
2018-2022
A better way to treat complex diseases such as cancer is aim for several targets at once. Beta-carboline derivatives have been shown anticancer activity, but these compounds may target enzymes required cell division. Polo-like kinases (PLKs) are well conserved serine/threonine and PLK1 plays multiple roles in proliferation. Thus, one of the attractive mitotic drugs. We found that DH166, a beta-carboline derivative, inhibits growth cdc5-2 temperature-sensitive mutant more profoundly than...
Highlights•HTS discovers nutraceutical compounds MPTC and PEITC that restore function in AATD•MPTC regulate cellular redoxstasis to AATD through PDIA4•GP-SCV machine learning captures residue-by-residue responses of AAT MPTC/PEITC•GP-SCV provides an atomic-resolution description regulation AATDSummaryAlpha-1 antitrypsin (AAT) deficiency (AATD) is a monogenic disease caused by misfolding variants resulting gain-of-toxic aggregation the liver loss monomer activity lung leading chronic...
Verticillium wilt (VW) is a typical fungal disease affecting the yield and quality of cotton. The Trichome Birefringence-Like protein (TBL) an acetyltransferase involved in acetylation process cell wall polysaccharides. Up to now, there are no reports on whether
Genetic variation in human populations can result the misfolding and aggregation of proteins, giving rise to systemic neurodegenerative diseases that require management by proteostasis. Here, we define role GRP94, endoplasmic reticulum Hsp90 chaperone paralog, managing alpha-1-antitrypsin deficiency on a residue-by-residue basis using Gaussian process regression-based machine learning profile spatial covariance relationships dictate protein folding arising from sequence variants population....
Cotton is one of the world's most important economic crops. Verticillium wilt a devastating cotton disease caused by
A biological method for synthesising silver nanoparticles (AgNPs) was developed using the callus extracts from Artemisia annua L. under sunlight at 25,000 lx. The AgNPs were characterised transmission electron microscopy, atomic force microscope, X-ray diffraction and Fourier transform infrared spectroscopy. mostly spherical with size of 2.1 to 45.2 nm (average 10.9 nm). Pulse treatments 125, 250 500 mg/l 1 h extended vase life cut carnation (Dianthus caryophyllus cv. Green Land) flowers....
Abstract Sika deer are known to prefer oak leaves, which rich in tannins and toxic most mammals; however, the genetic mechanisms underlying their unique ability adapt living jungle still unclear. In identifying mechanism responsible for tolerance of a highly diet, we have made major advancement elucidation genomics sika deer. We generated first high-quality, chromosome-level genome assembly measured correlation between tannin intake RNA expression 15 tissues through 180 experiments....
The aim of this study was to explore the effect aquaporin on molecular mechanism human diabetic myocardial cell apoptosis. methylthiazolyle tetrazolium assay used detect inhibitory different concentrations growth. rate aquaporin-induced apoptosis detected by flow cytometric analysis Annexin V-fluorescein isothiocyanate/propidium iodide double-stained cells. We also attempted quantify expression Bcl-2, Bax, caspase-3, and survivin in cells western blot analysis. Aquaporin found inhibit...
Locating of important agronomic genes onto chromosome is helpful for efficient development new wheat varieties. Wheat substitution lines between two varieties have been widely used locating because their distinctive advantages in genetic analysis, compared with the aneuploid materials. Apart from substituted chromosome, other chromosomes and recipient parent should be identical, which eases gene practice. In this study, a set cv. Wichita (WI) as Cheyenne (CNN) donor were studied composition...