A5064619572- Thyroid Cancer Diagnosis and Treatment
- Reproductive Biology and Fertility
- Ovarian function and disorders
- Thyroid and Parathyroid Surgery
- Ovarian cancer diagnosis and treatment
- Reproductive Physiology in Livestock
- Cancer Cells and Metastasis
- Kruppel-like factors research
- Head and Neck Anomalies
- Angiogenesis and VEGF in Cancer
- Genetic and Kidney Cyst Diseases
- Ferroptosis and cancer prognosis
- Cancer Diagnosis and Treatment
- Radiation Dose and Imaging
- Endoplasmic Reticulum Stress and Disease
- Cancer Risks and Factors
- Cancer-related molecular mechanisms research
- Single-cell and spatial transcriptomics
- BRCA gene mutations in cancer
Shanghai Sixth People's Hospital
2020-2024
Shanghai Jiao Tong University
2020-2024
Zhejiang Cancer Hospital
2020
Medizinische Fakultät Mannheim
2011
Heidelberg University
2011
Memorial Hospital of South Bend
1997
Despite extensive research, the papillary thyroid carcinoma (PTC) ecosystem is poorly characterized and, in particular, locoregional progression. Available evidence supports that single-cell transcriptome sequencing (Sc-RNA seq) can dissect tumor ecosystems.Tissue samples from one PTC patient, including matched primary (Ca), lymph node (LN) metastasis, and paracancerous tissue (PCa), were subjected to Sc-RNA seq with 10×Genomics. Dual-label immunofluorescence immunohistochemistry used...
Surgical, thyroid hormone and radioactive 131I therapy are the standard curative treatments for well differentiated cancer. However, residual, recurrent nodal involvement of cancer, external radiotherapy may be important in preventing distant metastases. The postoperative treatment human cancer with is controversial. We retrospectively reviewed records 699 patients papillary or follicular whom 72 received after surgery. Thirty-two these were at clinical stage 2 3 time diagnosis while 172...
Abstract Chemotherapy-induced ovarian dysfunction is a serious adverse effect in premenopausal patients with cancer. Gonadotrophin-releasing hormone analogs (GnRHa) protect function, but its molecular mechanisms have not yet been determined. In this study, we attempted to determine the previously unknown mechanism by which such protection occurs. Serum anti-Müllerian (AMH) levels were tested tumor-bearing nude mice, series of exploratory experiments conducted. We discovered that GnRHa...
The predictive value of anti-Müllerian hormone (AMH) for ovarian dysfunction postchemotherapy is controversial. This study aimed to evaluate the serum AMH levels clinically and theoretically.We detected estradiol, follicular stimulating (FSH), luteinizing (LH), in 144 premenopausal women with breast cancer receiving cyclophosphamide-based chemotherapy. before were compared; correlations among hormones amenorrhea menstrual recovery analyzed. In addition, randomly 177 normal healthy 36 female...
Abstract PurposesDistant metastasis from papillary thyroid microcarcinoma (PTMC) is extremely rare and the long-term outcome independent prognostic factors remain unclear.The present study aimed to investigate clinicopathological characteristics evaluate outcomes of PTMC patients with distant metastases (DM) who underwent surgery radioactive iodine ( 131 I) treatment.MethodsWe retrospectively reviewed medical records 13,441 cancer (including 1,697 cases PTMC) I treatment at our institution...
Aims: Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. Most tumors are stroma-poor but highly vascularised. Overexpression tip cell marker and Notch ligand delta like 4 (DLL4) has been described in many tumor entities not yet investigated human HCCs. First attempts have made to further characterize vasculature, date no clear data exist about sprouting angiogenesis its relation malignant transformation HCCs (“angiogenic switch“).
Abstract Background The predicting value of AMH for ovarian dysfunction after chemotherapy is controversial. This study designed to evaluate the serum clinically and theoretically. Patients, animals methods We detected estradiol, FSH in 144 pre-menopausal women with breast cancer receiving cyclophosphamide-based chemotherapy. differences hormones before were compared; correlations among amenorrhea, menstrual recovery analyzed. In addition, was randomly 177 normal healthy 36 female C57BL/6J...
Abstract Background The predicting value of AMH for ovarian dysfunction after chemotherapy is controversial. This study designed to evaluate the serum clinically and theoretically. Methods We detected estradiol, FSH in 144 pre-menopausal women with breast cancer receiving cyclophosphamide-based chemotherapy. differences hormones before were compared; correlations among amenorrhea, menstrual recovery analyzed. In addition, was randomly 177 normal healthy 36 female C57BL/6J mice different...