A5100658344- Thyroid Cancer Diagnosis and Treatment
- Thyroid and Parathyroid Surgery
- Clinical practice guidelines implementation
- Global Healthcare and Medical Tourism
- Parathyroid Disorders and Treatments
- Head and Neck Anomalies
- Cancer Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Multiple and Secondary Primary Cancers
- MicroRNA in disease regulation
- Management of metastatic bone disease
- Hernia repair and management
- Cancer-related gene regulation
- Colorectal Cancer Surgical Treatments
- Renal and Vascular Pathologies
- RNA modifications and cancer
- BRCA gene mutations in cancer
- Esophageal and GI Pathology
- Genetic Syndromes and Imprinting
- Cardiac, Anesthesia and Surgical Outcomes
- Ferroptosis and cancer prognosis
- S100 Proteins and Annexins
- Wnt/β-catenin signaling in development and cancer
- Pancreatic and Hepatic Oncology Research
- Circular RNAs in diseases
Shanghai Jiao Tong University
2016-2025
Shanghai Sixth People's Hospital
2016-2025
Northwest University
2025
Northwestern University
2018-2024
University of Southern California
2018-2023
Chongqing Medical University
2017
Sun Yat-sen University
2015
Fujian Medical University
2015
Kunming Medical University
2015
China Medical University
2015
Background/Aims: Micro-RNA (miR)-146b-5p is overexpressed in papillary thyroid carcinoma (PTC) and associated with extrathyroidal invasion advanced tumor stage. In the present study, we showed that miR-146b-5p upregulated PTC lymph node metastasis. Methods: A computational search luciferase assay identified zinc RING finger 3 (ZNRF3), a negative regulator of Wnt/β-catenin signaling, as direct target PTC. Results: MiR-146b-5p promoted migration invasiveness induced epithelial-mesenchymal...
MicroRNAs (miRNAs) are strongly implicated in many cancers, including papillary thyroid carcinoma (PTC), which is the most common malignancy tissue. Recently, miRNA-155 (miR-155) has been proved to play a substantial role liposarcoma and breast cancer, but its functions context of PTC remain unknown. The objective was investigate potential involvement miR-155 PTC. Expression levels were assessed via quantitative real-time PCR 20 pairs human adjacent normal tissues 4 cell lines. Lentiviral...
microRNAs (miRNAs) are involved in the pathogenesis of diverse human cancers through its target genes, including papillary thyroid cancer (PTC). However, there few studies regarding associations between clinicopathological features PTC with expression specific miRNAs and potential genes. In present study, analysis miRNA was integrated mRNA profiles aggressive PTC. gene arrays were used to identify a subset differentially expressed mRNAs non-aggressive PTCs. These further validated by qPCR...
The incidence rate of medullary thyroid carcinoma (MTC) continues to grow, along with its mortality in the USA. However, subgroup trends MTC have not yet been established. This population-based retrospective cohort study was based on Surveillance, Epidemiology, and End Results (SEER) 17/12 registry database. Subgroup analysis performed through clinicopathological treatment-related characteristics. Annual average percentage change (AAPC) calculated using joinpoint regression analysis. A total...
// Wangwang Qiu 1, * , Zhili Yang Youben Fan 1 Qi Zheng Department of General Surgery, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, 200233, P.R. China These authors contributed equally to this work Correspondence to: Zheng, email: zhengqi1957@aliyun.com Keywords: papillary thyroid cancer, miR-613, SphK2, cell growth, invasion Received: January 18, 2016 Accepted: April 26, Published: May 21, 2016 ABSTRACT MicroRNAs (miRNAs) have emerged...
Anaplastic thyroid cancer (ATC) is associated with poor prognosis and often untreatable. MicroRNA 483-3p (miR-483) partitioning-defective 3 (Pard3), a member of the Pard family, have functions regulatory mechanisms in ATC. The abnormal regulation miR-483 may play an important role tumorigenesis, Par3 known to regulate cell polarity, migration, division. Tumor proliferation promoted by miRNA expression can be regulated upregulating transforming growth factor-β1 (TGF-β1), which thought...
Abstract Objective To define somatic variants of parathyroid adenoma (PA) and to provide novel insights into the underlying molecular mechanism sporadic PA. Methods Basic clinical characteristics biochemical indices 73 patients with PA were collected. Whole-exome sequencing was performed on matched tumor-constitutional DNA pairs detect alterations. Functional annotation carried out by ingenuity pathway analysis afterward. The protein expression variant gene confirmed immunohistochemistry,...
Despite extensive research, the papillary thyroid carcinoma (PTC) ecosystem is poorly characterized and, in particular, locoregional progression. Available evidence supports that single-cell transcriptome sequencing (Sc-RNA seq) can dissect tumor ecosystems.Tissue samples from one PTC patient, including matched primary (Ca), lymph node (LN) metastasis, and paracancerous tissue (PCa), were subjected to Sc-RNA seq with 10×Genomics. Dual-label immunofluorescence immunohistochemistry used...
Angiogenesis is essential for tumour growth and metastasis necrosis factor (TNF)-alpha a potent angiogenic factor. Invasive micropapillary carcinoma of the breast (IMPC), rare subtype cancer, possesses lymphotropic nature with high incidence lymph node poor prognosis. The aim was to evaluate role TNF-alpha its receptor TNFRII in vascular development IMPC.One hundred cases IMPC 97 invasive ductal carcinoma, not otherwise specified (IDC) were studied parallel by immunohistochemistry TNFRII,...
Abstract Introduction Near‐infrared autofluorescence imaging (NIFI) can be used to identify parathyroid gland (PG) during surgery. The purpose of the study is establish a new model, help surgeons better identify, and protect PGs. Methods Five hundred twenty three NIFI images were selected. PGs recorded by marked with artificial intelligence (AI) model. recognition rate for was calculated. Analyze differences between different years experience AI recognition, evaluate diagnostic therapeutic...
Few studies have investigated the impact of primary tumor resection (PTR) on patients with distant metastasis medullary thyroid carcinoma (DMMTC). This population-based study aims to assess application PTR in DMMTC patients, ascertain its benefits, and identify optimal surgical indications. Patients diagnosed between 2010 2020 were included through Surveillance, Epidemiology, End Results (SEER) program. Logistic regression analysis identified driving factors decision-making. Propensity score...
No prior studies have described or stratified the difficulty of transoral and submental thyroidectomy (TOaST). We aimed to investigate preoperative factors as indicators difficult TOaSTs develop a predictive model accordingly. This retrospective study included 255 eligible DTC patients who underwent total central neck dissection (CND) via endoscopic approach between February 2021 April 2024. These were randomized into training validation groups in 7:3 ratio. Procedures categorized normal...
Secondary hyperparathyroidism (SHPT) is characterized by parathyroid hyperplasia, persistently elevated hormone levels, and disturbances in mineral metabolism. Currently, a considerable amount of literature has consistently shown that thermal ablation effective maintaining levels within an appropriate range, normalizing calcium phosphorus improving clinical symptoms, reducing the volume glands. However, there are currently no established guidelines regarding its utilization. The Asian...