A5075828752- Multiple Myeloma Research and Treatments
- Platelet Disorders and Treatments
- Blood groups and transfusion
- Chronic Lymphocytic Leukemia Research
- Acute Myeloid Leukemia Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Blood properties and coagulation
- Hemoglobinopathies and Related Disorders
- Lymphoma Diagnosis and Treatment
- Blood Coagulation and Thrombosis Mechanisms
- Peptidase Inhibition and Analysis
- Blood disorders and treatments
- Complement system in diseases
- Immunodeficiency and Autoimmune Disorders
- Acute Lymphoblastic Leukemia research
- Kruppel-like factors research
- GDF15 and Related Biomarkers
- Neutropenia and Cancer Infections
- Renal Diseases and Glomerulopathies
- Advanced Glycation End Products research
- Systemic Lupus Erythematosus Research
- S100 Proteins and Annexins
- Mycobacterium research and diagnosis
- Erythrocyte Function and Pathophysiology
- Autoimmune Bullous Skin Diseases
Kocaeli Üniversitesi
2015-2024
Sağlık Bilimleri Üniversitesi
2020-2021
Bolu Abant İzzet Baysal University
2021
TUBITAK BILGEM
2020
Palmetto Hematology Oncology
2013
The purpose of the study was to evaluate plasminogen activator inhibitor-1 (PAI-1) levels and PAI-1 activity in young lean women with PCOS compare controls matched for age weight. Thirty two 25 weight age-matched healthy participated this study. Patients were evaluated clinically by pelvic ultrasound fasting blood samples taken hematological biochemical tests. Fasting insulin, glucose, lipid profile, FSH, LH, PRL, testosterone, SHBG, 17-hydroxyprogesterone, androstenedione, antigen;...
Immune thrombocytopenia (ITP) is an autoimmune disease characterized by dysregulation of T cells. Programmed death (PD) 1 and programmed ligand (PD-L1) are cosignaling molecules, the major role PD-1 pathway inhibition self-reactive cells to protect against diseases. We measured levels serum soluble PD (sPD-1) PD-L1 (sPD-L1) in 67 patients with ITP (24 newly diagnosed [ndITP], 43 chronic [cITP]) 21 healthy controls (HCs). determined decreased sPD-1 both ndITP cITP when compared HC. Moreover,...
Abstract Objectives Hepcidin plays a regulatory role in systemic iron homeostasis. GDF ‐15 has been found to be expressed from matured erythroblasts and very high levels of suppresses hepcidin secretion. In this study, we evaluated polycythemia vera ( PV ) essential thrombocythemia ET ). Methods The study included 29 patients 21 healthy controls. patient group 13 with 16 . Serum were measured at the time diagnosis, before initiation any therapy. Results did not differ significantly chronic...
<b><i>Background/Aims:</i></b> Multiple myeloma (MM) is a hematological cancer associated with increased clonal malignant plasma cells. Growth differentiation factor 15 (GDF 15) protein that highly expressed in the bone marrow mesenchymal stem cells of patients MM. This study investigated whether clinical stage disease, treatment response and survival are affected by pretreatment serum GDF levels. <b><i>Methods:</i></b> Serum levels were...
Background: IL-6, IL1-β, TNF-α and IL-21 have been identified in the growth, progression dissemination of multiple myeloma. To dte, there is no published data about serum levels patients with In present study we investigated circulating cytokines, such as IL-1β, TNF-α, association these disease stage newly diagnosed myeloma patients. Materials Methods: Twenty healthy controls 44 were evaluated. Patients classified according to Durie-Salmon criteria, international staging system (ISS) bone...
Abstract Introduction Hodgkin lymphoma (HL) is unusual among malignancies, with inflammation playing such a prominent role in its pathogenesis. S100A8/A9 (calprotectin) heterodimeric protein, which has the inflammatory response and oncogenesis. In this study HL patients, correlation between serum levels treatment responses was investigated along whether marker correlated other markers. Materials Methods Thirty‐three patients 20 healthy volunteers were included. Demographic clinical...
Objective:The aim of the present study was to evaluate efficacy and safety eltrombopag, an oral thrombopoietin receptor agonist, in patients with chronic immune thrombocytopenia (ITP). Materials Methods:A total 285 ITP (187 women, 65.6%; 98 men, 34.4%) followed 55 centers were enrolled this retrospective cohort.Response treatment assessed according platelet count (/mm 3 ) defined as complete (platelet >100,000/mm ), partial (30,000-100,000/mm or doubling after treatment), unresponsive...
GDF15, hepcidin and mitoferrin-1 (mfrn-1) are proteins involved in systemic iron regulation. There no studies the literature demonstrating serum mfrn-1 levels polycythemia vera (PV) essential thrombocythemia (ET) patients. The aim of this study was to investigate PV ET patients.Materials methods: Ten PV, 17 patients, 27 healthy controls (HCs) were enrolled. values measured with enzyme-linked immunosorbent assay (ELISA).Results: GDF15 higher myeloproliferative neoplasm (MPN) group (P =...
Background: Eltrombopag (EPAG), an oral thrombopoietin receptor agonist, is approved in the Middle East Turkey, Asia and Australia for treatment of thrombocytopenia adults with chronic immune (cITP) insufficient response to prior therapy, such as corticosteroids immunoglobulins. To date, real‐world data on EPAG use patients (pts) cITP have not been collected a systematic manner most countries outside US Europe. CITE prospective non‐interventional study (targeted recruit ∼300 pts from June...
Amaç: Bu çalışmada, kemik iliğindeki (Kİ) blast oranı >%30 olan olguları da içeren akut miyeloid lösemili (AML) yaşlı hastalarda, azasitidinin (AZA) etkinliğinin ve güvenliğinin araştırılmasını amaçladık.Gereç Yöntemler: geriye dönük, çok merkezli çalışmaya, yoğun kemoterapi için uygun olmayan ya konvansiyonel tedavilere rağmen hastalığı ilerleyen ≥60 yaştaki 130
Abstract CITE was a prospective, noninterventional study in adult patients with chronic immune thrombocytopenia treated eltrombopag under routine clinical care Asia-Pacific, the Middle East, and Turkey. Data to assess usage, compliance, outcomes were collected from May 2017 December 2020. Platelet response defined as platelet count ≥50 × 103/μL absence of rescue medications splenectomy. Quality life evaluated using Functional Assessment Chronic Illness Therapy-Fatigue (FACIT-F)...
Two-thirds of newly diagnosed patients with multiple myeloma (MM) are over 65 yr and/or physically unfit. Such not eligible for high-dose chemotherapy or stem cell transplantation. The treatment aims in these should be to prolong survival by obtaining the best possible response, while maintaining good tolerability. aim our study was evaluate response and treatment-related toxicities treated conventional novel protocols.The records 138 elderly (≥65 yr) MM were retrospectively evaluated.The...
Background: Tumor lysis syndrome (TLS) is a potentially fatal complication of cancer therapy characterized by severe electrolyte and metabolic abnormalities such as hyperphosphatemia, hyperkalemia, hypocalcaemia. TLS usually occurs in aggressive hematologic malignancies Burkitt lymphoma acute leukemia. has rarely been observed multiple myeloma (MM). Case report: We present 2 patients with relapsed MM who developed after the first cycle carfilzomib treatment. Conclusion: Carfilzomib...
Vascular events are a common complication in patients with polycythemia vera (PV) and essential thrombocythemia (ET). This study aimed to analyze the association between PAI-1 4G/5G ACE I/D gene polymorphisms, leukocytosis thrombosis PV ET.In total, 64 ET were evaluated. Arterial or venous thrombosis, such as cerebral transient ischemic attack, stroke, myocardial infarction, peripheral arterial deep pulmonary embolism, defined vascular event. DNA samples screened for mutations via reverse...
Anticonvulsant hypersensitivity syndrome is a fatal, idiosyncratic drug reaction that caused by aromatic antiepileptic drugs. This cutaneous also called pseudolymphoma because of its clinical and histological similarities with malignant lymphoma. The primary findings are fever, skin rashes, enlarged lymph nodes, single or multiple internal organ involvement hematological abnormalities. Typically, anticonvulsant occurs 1-8 weeks after administration. We herein present the case patient who had...
Immune thrombocytopenia (ITP) is an autoimmune disease characterized by peripheral thrombocyte destruction. In some disorders, heat-shock proteins (HSP) are suggested to be important antigenic factor. this study, we demonstrated the serum free levels of HSP60, HSP70, anti-HSP60, and anti-HSP70 in ITP patients healthy controls. Twenty-eight newly diagnosed patients, 35 chronic phase, 25 controls were enrolled study. Serum determined ELISA method. HSP60 significantly decreased when compared...