Lei Cheng

ORCID: 0000-0003-0856-5359
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About
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Research Areas
  • Spine and Intervertebral Disc Pathology
  • Nerve injury and regeneration
  • Spinal Fractures and Fixation Techniques
  • Cervical and Thoracic Myelopathy
  • Bone Tissue Engineering Materials
  • Mesenchymal stem cell research
  • MicroRNA in disease regulation
  • Medical Imaging and Analysis
  • Circular RNAs in diseases
  • Pain Mechanisms and Treatments
  • Error Correcting Code Techniques
  • Oral microbiology and periodontitis research
  • Advanced Algorithms and Applications
  • Advanced Wireless Communication Techniques
  • Graphene and Nanomaterials Applications
  • Venous Thromboembolism Diagnosis and Management
  • Central Venous Catheters and Hemodialysis
  • Salivary Gland Disorders and Functions
  • Autophagy in Disease and Therapy
  • Tissue Engineering and Regenerative Medicine
  • Dental Health and Care Utilization
  • Endoplasmic Reticulum Stress and Disease
  • Power Transformer Diagnostics and Insulation
  • Pluripotent Stem Cells Research
  • Cancer-related molecular mechanisms research

Qilu Hospital of Shandong University
2015-2025

Stomatology Hospital
2019-2025

Sichuan University
2007-2025

State Key Laboratory of Oral Diseases
2020-2025

National Clinical Research
2025

Zhejiang Provincial People's Hospital
2025

China Three Gorges University
2022-2025

Wuhan Academy of Agricultural Sciences
2025

Lu'an First People's Hospital
2025

Anhui Medical University
2025

Purpose To evaluate incidence and risk factors of peripherally inserted central catheter (PICC)-related complications in cancer patients. Methods A prospective, multicenter, cohort study patients with PICC insertion was performed from February 1, 2013 to April 24, 2014. All were monitored clinic until PICCs removed. The primary endpoint removal due complications. Patient-, catheter- insertion-related analyzed univariable multivariable logistic regression analysis identify significant...

10.5301/jva.5000670 article EN The Journal of Vascular Access 2017-02-17

Low back pain and sciatica caused by intervertebral disc (IVD) disease are associated with inflammatory responses. The cytokine interleukin 17 (IL-17) is elevated in herniated degenerated IVD tissues acts as a regulator of inflammation. objective this study was to investigate the involvement IL-17A response explore mechanisms underlying response. Cells were isolated from nucleus pulposus (NP) collected patients undergoing surgeries for degeneration. concentrations COX2 PGE2, well select...

10.1186/s12967-016-0833-9 article EN cc-by Journal of Translational Medicine 2016-03-17

Zinc (Zn) alloys provide a new generation for orthopedic applications due to their essential physiological effects and promising degradation properties. However, excessive release of Zn ions (Zn2+ ) during the severe inflammatory microenvironment are not conducive osseointegration, which is determined by characteristics implant surface. Therefore, it modulate rate surface modification technology endow them with anti-inflammatory osteogenic effects. In this study, two kinds phosphate chemical...

10.1002/adhm.202202537 article EN Advanced Healthcare Materials 2022-12-18

The method of Support Vector Machine (SVM) based on Dissolved Gas Analysis (DGA) has been studied in the field power transformer fault diagnosis. However, there are still some shortcomings, such as fuzzy boundaries DGA data, and SVM parameters difficult to determine. Therefore, this paper proposes a diagnosis Kernel Principal Component (KPCA) hybrid improved Seagull Optimization Algorithm optimize (TISOA-SVM). Firstly, KPCA is used extract features from feature quantities. In addition, TISOA...

10.1109/access.2021.3127164 article EN cc-by IEEE Access 2021-11-10

The current standard of care for cervical myopathy is anterior discectomy and fusion (ACDF). Although well tolerated in the short term, this treatment might ultimately result progressive degeneration adjacent motion segments. Artificial disc arthroplasty offers theoretical advantage preservation at operative level with consequent stress reduction levels.We compared function, radiographic measures, incidence complications 3-year followup after Bryan(®) prosthesis ACDF patients...

10.1007/s11999-011-2039-z article EN Clinical Orthopaedics and Related Research 2011-10-13

Haptic feedback plays a key role in surgeries, but it is still missing component robotic Minimally Invasive Surgeries. This paper proposes dynamic model-based sensorless grip force estimation method to address the haptic perception problem for commonly used elongated cable-driven surgical instruments. Cable and cable-pulley properties are studied modeling; forces, along with driven motor gripper jaw positions velocities jointly estimated Unscented Kalman Filter only encoder readings output...

10.1109/icra.2016.7487605 article EN 2016-05-01

p204 is a member of the interferon-inducible p200 family proteins in mice. The has been reported to be multifunctional regulators cell proliferation, differentiation, apoptosis and senescence. Interferon-inducible protein 16 (IFI16) regarded as human ortholog several studies. This possibly due similarity their structures. However consistency functions still elusive. Currently, an emerging focus placed upon role sensors for microbial DNA innate immune responses provides new insights into...

10.1016/j.gendis.2014.10.003 article EN cc-by-nc-nd Genes & Diseases 2014-11-01

Abstract A major pathological basis for low back pain is intervertebral disk degeneration, which primarily caused by the degeneration of nucleus pulposus cells due to imbalances in extracellular matrix (ECM) anabolism and catabolism. The phenotype macrophages local immune microenvironment greatly influences balance ECM metabolism. Therefore, control over macrophage promising repair degeneration. Herein, preparation an injectable nanocomposite hydrogel reported embedding...

10.1002/advs.202304480 article EN cc-by Advanced Science 2023-11-08

The Shenyu River, as the tributary of Jinsha River closest to Wudongde Hydropower Station, has had seven landslides developed on its right bank, forming an interconnected landslide group system. evolution and future development trends have a significant impact safe operation Station. Using geological field surveys exploration data, we studied analyzed formation mechanism bank in reservoir area main conclusions are follows: local structure study is mainly composed north–south faults folds,...

10.3390/w17040505 article EN Water 2025-02-11

Dairy cow mastitis is a common and prevalent disease arose by various complicated pathogeny, which poses serious threat to the health of cows, safety dairy product economic benefits for pastures. Due high stealthiness long incubation period, subclinical (SM) cows causes enormous losses. Besides infection exogenous pathogenic microorganisms, previous studies demonstrated that gastrointestinal microbial dysbiosis one crucial occurrence development based on theory entero-mammary axis. Whereas,...

10.1186/s12866-025-03810-1 article EN cc-by-nc-nd BMC Microbiology 2025-03-04

The cervical spine's mobility affects the compression level of cord which varies with dynamic positioning. High signal on MRI T2-weight imaging (MRI-T2WI) indicates a poorer prognosis. This study investigates relationship between high-signal intensity MRI-T2WI and change using kinematic MRI. objective this was to explore changes in degree spinal during flexion-extension motions identify risk factors linked occurrence high signals. We collected data patients who underwent surgical treatment...

10.1186/s13018-025-05715-1 article EN cc-by-nc-nd Journal of Orthopaedic Surgery and Research 2025-04-09

Currently, emerging dynamic therapy has gradually become a frequently used strategy for treating infectious bone defects via rise in reactive oxygen species (ROS) levels, which can bring about oxidative harm to bacteria. However, ROS be generated only under conditions of exogenous energy, limited by energy penetration or dependence on the existence internal O2/H2O2. Thus, we designed Na2S2O8-decorated polyetheretherketone implants activated Fe2+ infected defects. In vitro experiments show...

10.1021/acsnano.5c04147 article EN ACS Nano 2025-05-11

ABSTRACT Background The liver often serves as the principal site for metastatic spread from a variety of solid tumors, and metastasis to markedly diminishes patient survival. Single‐cell RNA sequencing (scRNA‐seq) has helped uncover complexity tumor metastasis. However, key cellular subtypes breast cancer pancreatic ductal adenocarcinoma (PDAC) with their mechanisms action are unclear, making treatment difficult. Methods We used integrated scRNA‐seq data dissect metastasis‐specific...

10.1002/cam4.70904 article EN cc-by Cancer Medicine 2025-05-01
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