A5068860191- Respiratory viral infections research
- Pneumonia and Respiratory Infections
- Influenza Virus Research Studies
- Antimicrobial Resistance in Staphylococcus
- ATP Synthase and ATPases Research
- Streptococcal Infections and Treatments
- RNA Interference and Gene Delivery
- Clostridium difficile and Clostridium perfringens research
- Bacterial Identification and Susceptibility Testing
- COVID-19 Impact on Reproduction
- Microbial infections and disease research
- Intensive Care Unit Cognitive Disorders
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Viral gastroenteritis research and epidemiology
- Second Language Learning and Teaching
- Frailty in Older Adults
- SARS-CoV-2 and COVID-19 Research
- Rabies epidemiology and control
- Mitochondrial Function and Pathology
- Viral Infections and Immunology Research
- Drug Transport and Resistance Mechanisms
- Bacterial biofilms and quorum sensing
- Porphyrin and Phthalocyanine Chemistry
- Soil and Water Nutrient Dynamics
Skåne University Hospital
2014-2024
Lund University
2012-2024
Uppsala University Hospital
2024
Uppsala University
2024
Malmö University
2008-2010
Ideon Science Park
2007
Smart High Tech (Sweden)
2007
Diagnosis of Mycoplasma pneumoniae (MP) infection is traditionally based on serology, which may require more than two weeks for diagnostic antibodies to develop. PCR-based methods offer earlier diagnosis. During a community outbreak MP infection, we compared semi-nested and real-time PCR oropharyngeal swabs with serology diagnosis at different time points after disease onset. PCR-positive individuals were followed longitudinally assess the persistence DNA in throat secretions. We also...
ABSTRACT Nasal decolonization has a proven effect on the prevention of severe Staphylococcus aureus infections and control methicillin-resistant S. (MRSA). However, rising rates resistance to antibiotics highlight need for new substances nasal decolonization. LTX-109 is broad-spectrum, fast-acting bactericidal antimicrobial drug topical treatment, which causes membrane disruption cell lysis. This mechanism action not associated with cross-resistance low propensity development resistance. In...
Disease severity in Mycoplasma pneumoniae (MP) infection could potentially be related to bacterial factors such as MP genotype (MP1 or MP2; distinguished by different adhesions proteins) load airway secretions. We have compared these parameters patients who were hospitalized for pneumonia, with outpatients mild disease. was measured real-time PCR 45 in- and ("clinical study group") whom DNA had been detected oropharyngeal secretions PCR. In addition, phylogenetic relationships determined....
Men are more severely affected by COVID-19. Testosterone may influence SARS-CoV-2 infection and the immune response. To clinically, epidemiologically, experimentally evaluate effect of antiandrogens on infection. A randomized phase 2 clinical trial (COVIDENZA) enrolled 42 hospitalized COVID-19 patients before safety evaluation. We also conducted a population-based retrospective study 7894 SARS-CoV-2–positive prostate cancer an experimental using air-liquid interface three-dimensional culture...
Abstract Background Numerous papers have been published evaluating the clinical benefits of robot-assisted microsurgery. In this study, we describe incorporation MUSA-2 robot (Microsure, Eindhoven, The Netherlands) into a plastic surgery unit outside its development centre. We aimed to assess implementation timeframes, areas future development, and key learning points for centres considering establishment microsurgery service. Methods identified 12 female patients with upper limb lymphoedema...
This document presents the 2012 evidence based guidelines of Swedish Society Infectious Diseases for in- hospital management adult immunocompetent patients with community-acquired pneumonia (CAP). The prognostic score 'CRB-65' is recommended initial assessment all CAP patients, and should be regarded as an aid decision-making concerning level care required, microbiological investigation, antibiotic treatment. Due to favourable resistance situation in Sweden, narrow-spectrum treatment...
The duration of colonization with methicillin-resistant Staphylococcus aureus (MRSA) is not well known and there debate as to whether a patient colonized MRSA ever can be defined 'MRSA-negative'.Since 2003 all notified cases have been systematically followed in Skåne County, southern Sweden. Cultures are taken from the nares, throat, perineum possible skin lesions. Contact tracing conducted. screening program continues long cultures positive then until 1 y consecutive negative for...
Six vaccine formulations containing AS02V or alum (aluminum phosphate [AlPO4]) adjuvant with pneumococcal proteins, histidine triad D (PhtD), and/or detoxified pneumolysin (dPly), either as a polysaccharide carrier in an 8-valent conjugate (8PCV) free (unconjugated) were evaluated adults -65 to 85 years of age. In this phase I observer-blind study, 167 healthy subjects randomized receive two doses (days 0 and 60) 10 30 μg PhtD-dPly plus alum, 8PCV one dose (day 0) 23-valent (23PPV) control...
Background Both skin and soft tissue infections (SSTI) systemic bacterial are common in people who inject drugs (PWID), but data on incidence risk factors lacking. We compared registered diagnoses for such Swedish criminal justice clients with regard to injecting drug use. Methods Baseline interview from the Prison Probation Service use PWID non-PWID problematic alcohol were linked follow-up national registers hospital and/or death. Associations between later diagnosis of SSTI infection...
Along with the current development of molecular diagnostic methods respiratory viruses, bedside patient sampling techniques need to be evaluated. We here asked question whether addition an oropharynx swab traditional nasopharynx might improve yield multiplex PCR analysis. Ct values from two sites were compared as well tolerability.In emergency department in Malmö, Sweden, 98 adult patients disease sampled both and for virus diagnostics by PCR.Influenza (AH1, AH3, B), human metapneumovirus...
For patients hospitalized with severe influenza A virus infection, morbidity and mortality remain high. MHAA4549A, a human monoclonal antibody targeting the hemagglutinin stalk, has demonstrated pharmacological activity in animal studies challenge study. We evaluated safety efficacy of MHAA4549A plus oseltamivir against infection patients. The CRANE trial was phase 2b randomized, double-blind, placebo-controlled study single intravenous (i.
Both the elderly and individuals with comorbidities are at increased risk of developing influenza-related complications. Novel influenza antivirals required, given limitations current drugs (eg, resistance emergence poor efficacy). Pimodivir is a first-in-class antiviral for A under development these patients.Hospitalized patients infection were randomized 2:1 to receive pimodivir 600 mg plus oseltamivir 75 or placebo twice daily 7 days in this phase 2b study. The primary objective was...
The proportion of Mycoplasma pneumoniae isolates carrying point mutations in the 23S region genome associated with macrolide resistance has increased. We evaluated probability developing M. during treatment.M. strains from initial and follow-up oropharyngeal samples 38 Swedish patients were tested for rRNA by amplifying pyrosequencing gene target region. duration symptoms carriage recorded cases without mutation.Macrolide absent all baseline strains. Twenty-two prescribed macrolides; longest...
Objectives This study aimed to investigate the etiology, clinical features, and outcomes of community-acquired pneumonia (CAP) in adults. Understanding causative pathogens is essential for effective treatment prevention. Design Between 2016–2018, 518 hospitalized adults with CAP 241 controls without symptoms were prospectively enrolled. Urine samples collected pneumococcal urinary antigen tests nasopharyngeal swabs viral bacterial analysis, combined routine diagnostic care. Results Among...
Today the casting structure of stamping tools is dimensioned according to standard guidelines. The main task develop an alternative method manufacturing tools, which takes structural response tool into account produce a lightweight design. This done by performing topology optimization with objective improve stiffness and reduce weight tool. die only part considered in methodology generation. established can be applied any other analogously, after load cases are determined. Two different...
To investigate the prevalence, distribution, and colonization burden of Staphylococcus aureus (S. aureus) MRSA in different body sites among people who inject drugs (PWID) compare it to a control group consisting non-injectors. In this cross-sectional survey, 49 active PWID from needle exchange program (NEP) Malmö, Sweden, 60 non-injecting controls an emergency psychiatric inpatient ward at Malmö Addiction Centre were tested for S. (including MRSA) by culture, PCR, MALDI-TOF. Samples taken...
To study influenza virus shedding during acute infection, viral load was longitudinally measured by quantitative PCR in nasal flocked swabs from patients with seasonal H3N2 at a Swedish emergency department, including both hospitalized and outpatients. Influenza A detected 65/184 patients. Sampling repeated every 3–4 days 45 patients, the aim of continuing sampling until day 12 after disease onset. Home visits were offered. Antibodies on paired sera 95/184 Fifty percent remained polymerase...
Fifty adult emergency room patients with symptoms of respiratory tract infections or acute onset extreme fatigue were sampled by both nasopharyngeal aspirate (NPA) and flocked nasal swab (fNS). Respiratory agents detected a qualitative influenza PCR an 18-valent multiplex in 20 29 clinical diagnosis infection, 3 21 without such diagnosis. A B NPA samples from 11 fNS 10 patients. Little no discomfort was perceived 60% the when 66% fNS. We conclude that equally sensitive for detection PCR, two...
Corticosteroids appears to be beneficial for severe Mycoplasma pneumoniae pneumonia in children but data adults are limited. This study investigated effects of adjunctive corticosteroids hypoxemic with M. pneumonia.