A5071575769- Synthesis and biological activity
- Enzyme function and inhibition
- Synthesis and Characterization of Heterocyclic Compounds
- Peptidase Inhibition and Analysis
- Microbial Applications in Construction Materials
- Cassava research and cyanide
- Maternal and fetal healthcare
- Maternal and Perinatal Health Interventions
- Politics and Conflicts in Afghanistan, Pakistan, and Middle East
- Morinda citrifolia extract uses
- Moringa oleifera research and applications
- Agricultural pest management studies
- Genital Health and Disease
- Macrophage Migration Inhibitory Factor
- vaccines and immunoinformatics approaches
- Animal Disease Management and Epidemiology
- Nonlinear Optical Materials Research
- ATP Synthase and ATPases Research
- Foreign Body Medical Cases
- Brucella: diagnosis, epidemiology, treatment
- Digestive system and related health
- Pelvic floor disorders treatments
- Phytase and its Applications
- Edible Oils Quality and Analysis
- Glutathione Transferases and Polymorphisms
Government College University, Lahore
2020-2023
University of Lahore
2018-2023
University of Sargodha
2023
Forman Christian College
2023
Filamer Christian University
2020
University of Agriculture Faisalabad
2013-2018
The enzyme urease is an essential colonizing factor of the notorious carcinogenic pathogen Helicobacter pylori (H. pylori), conferring acid resistance to bacterium. Recently, antibiotic resistant strains have emerged globally with little no alternative treatment available. In this study we propose novel inhibitors capable controlling infection by H. and other pathogenic bacteria. We employed hierarchal computational approaches screen new from commercial chemical databases followed in vitro...
The development of novel scaffolds that can increase the effectiveness, safety, and convenience medication therapy using drug conjugates is a promising strategy. As result, are an active area research in medicinal chemistry. This demonstrates acetamide–sulfonamide scaffold preparation after conjugation ibuprofen flurbiprofen with sulfa drugs, these were then screened for urease inhibition. newly designed confirmed by spectroscopic techniques such as IR, 1HNMR, 13CNMR, elemental analysis....
Derivative synthesis has been a crucial method for altering the effects of already-approved medications, especially to lessen adverse and enhance results. Making use this multi-target approach, series naproxen-sulfa drug conjugates was designed synthesized. The newly were confirmed by spectroscopic techniques like IR, 1HNMR, 13CNMR, elemental analysis. screened anti-inflammatory, urease, cyclooxygenase-2 (COX-2) inhibition. Naproxen conjugated with sulfanilamide, sulfathiazole,...
The search for novel drug scaffolds that can improve effectiveness and safety through conjugates is a promising approach. Consequently, constitute dynamic field of study advancement within medicinal chemistry. This research demonstrates the conjugation diclofenac mefenamic acid with sulfa drugs their screening urease inhibition. These conjugates' structural confirmation was performed using elemental analysis spectroscopic methods, including IR, 1H NMR, 13C NMR. Diclofenac conjugated...
When an infection, trauma or inflammation occurs due to any reason disease, it causes acute phase response.A lot of pathophysiological responses occur including pyrexia, pain, leukocytosis, removal pathogen causative agent minimizing the tissue damage and increasing repairing process.Acute proteins (APPs) are produced by hepatic extrahepatic sources.Liver production protein is regulated pro-inflammatory cytokines.Liver produces positive negative, both types APPs.The that plays significant...
Brucella melitensis is a facultative intracellular bacterial pathogen that causes abortion in goats and sheep Malta fever humans. In humans, chronic infection occurs through contact with infected animals or their waste products.The subtractive genomic approach considered as powerful useful method for the identification of potential drug vaccine targets. this study, an attempt has been made proteomic strategy to identify novel targets strains. Total 2604 core proteins 56 strains B. were...
Urease has become an important therapeutic target because it stimulates the pathogenesis of many human health conditions, such as pyelonephritis, development urolithiasis, hepatic encephalopathy, peptic ulcers, gastritis and gastric cancer. A series alkyl chain-linked thiourea derivatives were synthesized to screen for urease inhibition activity. Structure elucidation these compounds was done by spectral studies, IR,
Prebiotic yogurt (PY) with improved galacto-oligosaccharides (GalOS) was produced through transgalactosylation of lactose followed by physico-chemical and organoleptic evaluation. The chemical composition fresh prebiotic milk statistically (p > .05) similar except for which reduced from 4.8% in control to 1.9% milk. Lactose PY (1.44 ± 0.01%) as compared (3.4 0.02%), while other parameters, that is, fat, protein, pH, acidity were similar. (60%) bio-converted producing 0.9 g GalOS, glucose...
Retained surgical items are an uncommon complication for operations, with estimated incidence of 1 in 5500 to 18 000 operations. sponges the most common retained items, accounting nearly 70%. In 1884, Wilson reported first foreign body after laparotomy.A 22-year-old woman was referred our hospital complaining a feeling abdominal bloating and heaviness associated pain, fever, fatigue, severe stink vaginal discharges. Past history included cesarean section followed by laparotomy remove left...
Penile fracture, resulting from trauma to an erect penis, is a rare urogenital injury with potentially serious complications including erectile dysfunction. This case report emphasizes the significance of prompt recognition, accurate diagnosis, and timely surgical management optimize patient outcomes. The involves 34-year-old male presenting acute pain, swelling, visibly deformed penis following sexual intercourse. Clinical examination confirmed diagnosis penile leading repair tunica...
For environment-friendly, safe and nonpersistent chemical control of a significant polyphagous insect pest, Helicoverpa armigera, discovery growth-regulating xenobiotics can offer sustainable alternative to conventional insecticides. this purpose, chemically synthesized compounds inhibit sterol carrier protein (SCP-2) function using in silico vivo assays were evaluated estimate their impact on the survivals lifetable indices H. armigera. From nine compounds, OA-02, OA-06 OA-09 selected for...
Education has a tremendous impact on woman's capacity to build relationships with others based shared interests and experience the essential social benefit of self-esteem. Pakistan one lowest schooling rates in South Asia, which limits its human resources makes reforming country more difficult. Patriarchal ideas heavily influence societal structure Pakistan. for young men is favored over education women. The Human Development Report lists as having "low advancement" country's growth...