A5071421716- Viral gastroenteritis research and epidemiology
- Genomics and Phylogenetic Studies
- Gut microbiota and health
- Livestock and Poultry Management
- Bacteriophages and microbial interactions
- Helicobacter pylori-related gastroenterology studies
- Antibiotic Resistance in Bacteria
- RNA and protein synthesis mechanisms
- Antimicrobial Resistance in Staphylococcus
- Veterinary medicine and infectious diseases
- Reproductive tract infections research
- Microbial infections and disease research
- Animal Nutrition and Physiology
- Biochemical and Structural Characterization
- Preterm Birth and Chorioamnionitis
- Viral Infections and Immunology Research
- Vibrio bacteria research studies
- Salmonella and Campylobacter epidemiology
- Diet and metabolism studies
- Urinary Tract Infections Management
- Animal Disease Management and Epidemiology
- Bacterial biofilms and quorum sensing
- Nutritional Studies and Diet
- Probiotics and Fermented Foods
- Clostridium difficile and Clostridium perfringens research
COMSATS University Islamabad
2016-2025
University of California, Davis
2019
SUNY Upstate Medical University
2019
Balochistan University of Information Technology, Engineering and Management Sciences
2018
University of the Punjab
2011-2018
Technical University of Munich
2012-2013
WWF-India
2011
Natural antimicrobial agents, particularly essential oils present an excellent alternative to current antibiotics due their potent and broad-spectrum potential, unique mechanisms of action low tendency induce resistance. However potential as a viable therapeutic is greatly compromised hydrophobic volatile nature. The objective the research was explore anti-pathogenic in bio-based nano-carrier system. Six different were tested on multi-drug resistant bacterial pathogens. However, cardamom oil...
Type 2 diabetes mellitus (T2DM) accounts for 90% of cases worldwide. The majority T2DM patients are obese. Dysbiosis in the gut microflora is strongly associated with pathogenesis obesity and T2DM; however, microbiome obese-T2DM individuals Pakistani population remains unexplored. microbiota signature 60 adults was studied using 16S rRNA sequencing targeting V3–V4 hypervariable regions. sequence analysis revealed that bacteria from Firmicutes were predominant along those Clostridia...
Microbial lipases are an important group of biotechnologically valuable enzymes, because the versatility their applied properties and ease mass production. Lipases microbial origin widely diversified in enzymatic substrate specificity, which make them very attractive for industrial applications. This review describes applications detergents. Enzymes can reduce environmental load detergent products as chemicals used conventional detergents reduced; they biodegradable, non-toxic leave no...
Abstract Avian pathogenic E. coli (APEC) is associated with local and systemic infections in poultry, ducks, turkeys, many other avian species, leading to heavy economical losses. These APEC strains are presumed possess zoonotic potential due common virulence markers that can cause urinary tract humans. The prophylactic use of antibiotics the poultry sector has led rapid emergence Multiple Drug Resistant (MDR) act as reservoirs put human populations at risk. This calls for consideration...
Abstract Objective Multi-drug resistance (MDR) has notably increased in community acquired uropathogens causing urinary tract infections (UTIs), predominantly Escherichia coli . Uropathogenic E. causes 80% of uncomplicated UTIs, particularly pre-menopausal women. Considering this high prevalence and the potential to spread antimicrobial resistant genes, current study was conducted investigate presence clinically important strains Pakistani women having cystitis pyelonephritis. Women...
The enzyme urease is an essential colonizing factor of the notorious carcinogenic pathogen Helicobacter pylori (H. pylori), conferring acid resistance to bacterium. Recently, antibiotic resistant strains have emerged globally with little no alternative treatment available. In this study we propose novel inhibitors capable controlling infection by H. and other pathogenic bacteria. We employed hierarchal computational approaches screen new from commercial chemical databases followed in vitro...
Mastitis is considered one of the most widespread infectious disease cattle and buffaloes, affecting dairy herds. The current study aimed to characterize Staphylococcus aureus isolates recovered from subclinical mastitis animals in Pothohar region country. A total 278 milk samples 17 different farms around two districts region, Islamabad Rawalpindi, were collected screened for sub clinical using California Test. Positive processed isolation mannitol salt agar. analyzed their antimicrobial...
Pakistan is a multi-ethnic society where there disparity between dietary habits, genetic composition, and environmental exposures. The microbial ecology of healthy Pakistani gut in the context anthropometric, sociodemographic, patterns holds interest by virtue it being one most populous countries, also Lower Middle Income Country (LMIC). 16S rRNA profiling microbiome normo-weight individuals from different regions residence performed with additional meta-data collected through filled...
Water filtration plants are a main source of drinking water for local populations in almost all big cities Pakistan but these ineffective eliminating contaminants from water. This study was conducted to evaluate quality with specific focus on physicochemical parameters and bacterial contamination including occurrence multidrug-resistant bacteria collected (N = 64) the twin Pakistan. Physicochemical were analyzed following American Public Health Association standard guidelines total coliform...
The confounding consequences of Helicobacter bilis infection in experimental mice populations are well recognized, but the role this bacterium human diseases is less known. Limited data available on virulence determinants species. In pylori, γ-glutamyltranspeptidase (γGT) contributes to colonization gastric mucosa and pathogenesis peptic ulcer. γGT H. infections remains unknown. annotated genome sequence revealed two putative ggt genes our aim was characterize these paralogues. We performed...
Abstract Worldwide, breast cancer has an eminent morbidity and mortality rate, as it is a neoplastic disease among females. The query of the prospective danger bovine leukemia virus (BLV) to humans old but exceedingly topical focus scientific debate. objective current study was determine possible relationship between BLV cancer. A total 2710 formalin-fixed paraffin-embedded (FFPE) samples were selected regardless age, ethnicity, or municipality origin subjects. presence in human determined...
SPECIALTY GRAND CHALLENGE article Front. Syst. Biol., 17 June 2024Sec. Integrative Systems Microbiology Volume 4 - 2024 | https://doi.org/10.3389/fsysb.2024.1432791
Helicobacter bilis (H. bilis) infection is associated with cases of inflammatory bowel Disease, thyphlocolitis, hepatitis and cholecystitis. However, little known about the bacterial virulence determinants or molecular mechanisms involved. Recently, H. γ-glutamyltranspeptidase (HBgGT) was shown to be a factor decreasing host cell viability. Bacterial gGTs play key role in synthesis degradation glutathione enables bacteria utilize extracellular glutamine as sources glutamate. gGT-mediated...
Due to the rapid emergence of multidrug-resistant isolates, Campylobacter jejuni (C. jejuni) has been classified as a member priority pathogens group. This study aimed determine prevalence, antibiotic resistance patterns and source tracking clinical C. isolates from paediatric diarrhoeal patients in Pakistan. A total 150 stool samples children were processed for presence using culture, biochemical tests species-specific PCR. Antibiotic susceptibility was determined by disc diffusion method,...
Antimicrobial resistance (AMR) is a major global public health concern mainly affecting low- and middle-income countries (LMICs) due to lack of awareness, inadequate healthcare sanitation infrastructure, other environmental factors. In this study, we aimed link microbial assembly covariates (body mass index, smoking, use antibiotics) gut microbiome structure correlate the predictive antimicrobial gene prevalence (piARG) using PICRUSt2. We examined gastrointestinal oral profiles healthy...
A new species of scorpions the genus Orthochirus (Buthidae) is described from Jalna, Maharashtra, India.