A5028297592- Neuroinflammation and Neurodegeneration Mechanisms
- Advanced Glycation End Products research
- Alzheimer's disease research and treatments
- Immune cells in cancer
- Parkinson's Disease Mechanisms and Treatments
- Tryptophan and brain disorders
- Anesthesia and Neurotoxicity Research
- Retinoids in leukemia and cellular processes
- Stress Responses and Cortisol
- Heavy Metal Exposure and Toxicity
- Retinal Development and Disorders
- Immune Response and Inflammation
- Nuclear Receptors and Signaling
- Biochemical effects in animals
- Mercury impact and mitigation studies
- Phytochemicals and Antioxidant Activities
- Renal function and acid-base balance
- Cholesterol and Lipid Metabolism
- Biochemical and biochemical processes
- Nerve injury and regeneration
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Neuroblastoma Research and Treatments
- Healthcare Regulation
- Heat shock proteins research
- Fermentation and Sensory Analysis
Universidade Federal do Rio Grande do Sul
2015-2024
Patients recovering from sepsis have higher rates of CNS morbidities associated with long-lasting impairment cognitive functions, including neurodegenerative diseases. However, the molecular etiology these sepsis-induced impairments is unclear. Here, we investigated role receptor for advanced glycation end products (RAGE) in neuroinflammation, neurodegeneration-associated changes, and dysfunction arising after recovery. Adult Wistar rats underwent cecal ligation perforation (CLP), serum...
Abstract The receptor for advanced glycation endproducts (RAGE) is a pattern-recognition associated with inflammation in most cell types. RAGE up-regulates the expression of proinflammatory mediators and its own via activation NF-kB. Recent works have proposed role Parkinson’s disease (PD). In this study, we used multimodal blocker FPS-ZM1, which has become available recently, to selectively inhibit substantia nigra (SN) rats intracranially injected 6-hydroxydopamine (6-OHDA). FPS-ZM1 (40 μg...
Abstract Astrogliosis comprises a variety of changes in astrocytes that occur context‐specific manner, triggered by temporally diverse signaling events vary with the nature and severity brain insults. However, most mechanisms underlying astrogliosis were described using animals, which fail to reproduce some aspects human astroglial signaling. Here, we report an vitro model study human‐induced pluripotent stem cells (iPSC)‐derived replicate intertwined reactive vivo. We analyzed time course...
Abstract We aim to characterize the kinetics of early and late microglial phenotypes after systemic inflammation in an animal model severe sepsis effects minocycline on these phenotypes. Rats were subjected CLP, some animals treated with (10 ug/kg) by i.c.v. administration. Animals killed 24 hours, 5, 10 30 days induction, serum hippocampus collected for subsequent analyses. Real‐time PCR was performed M1 M2 markers. TNF‐α, IL‐1β, IL‐6, IL‐10, CCL‐22 nitrite/nitrate levels measured....
Systemic inflammation induces transient or permanent dysfunction in the brain by exposing it to soluble inflammatory mediators. The receptor for advanced glycation endproducts (RAGE) binds distinct ligands mediating and increasing processes. In this study we used an LPS-induced systemic model rats investigate effect of blocking RAGE serum, liver, cerebrospinal fluid (CSF) (striatum, prefrontal cortex, ventral tegmental area substantia nigra). Intraperitoneal injection antibody (50μg/kg) was...
Obesity is a health problem that has been associated with neuroinflammation, decreased cognitive functions and development of neurodegenerative diseases. Parkinson's disease (PD) chronic condition characterized by motor non-motor abnormalities, increased brain inflammation, α-synuclein protein aggregation dopaminergic neuron loss levels tyrosine hydroxylase (TH) in the brain. Diet-induced obesity global epidemic its role as risk factor for PD not clear. Herein, we showed 25 weeks on high-fat...
Familial hypercholesterolemia (FH) is a genetic disorder caused by dysfunction of low density lipoprotein receptors (LDLr), resulting in elevated plasma cholesterol levels. FH patients frequently exhibit cognitive impairment, finding recapitulated LDLr deficient mice (LDLr -/- ), an animal model FH. In addition, are more vulnerable to the deleterious memory impact amyloid-β (Aβ), peptide linked Alzheimer’s disease. Here, we investigated whether expression proteins involved Aβ metabolism...
Carvacrol (CARV) presents valuable biological properties such as anti-inflammatory and antioxidant activities. However, pharmacological uses of CARV are largely limited due to disadvantages related solubility, bioavailability, preparation storage processes. The complexation monoterpenes with β-cyclodextrin (β-CD) increases their stability, solubility oral bioavailability. Here, the protective effect treatment CARV/β-CD complex (25 μg/kg/day) against dopaminergic (DA) denervation induced by...
Sepsis is characterized by a severe and disseminated inflammation. In the central nervous system, sepsis promotes synaptic dysfunction permanent cognitive impairment. Besides sepsis-induced neuronal dysfunction, glial cell response has been gaining considerable attention with microglial activation as key player. By contrast, astrocytes’ role during acute still underexplored. Astrocytes are specialized immunocompetent cells involved in brain surveillance. this context, potential communication...
HSP70 is one of the main molecular chaperones involved in cellular stress response. Besides its chaperone action, also modulates immune Increased susceptibility to toxic insults intra- and extracellular environments has been associated with insufficient amounts inducible adult neurons. On other hand, exogenous administration demonstrated neuroprotective effects experimental models age-related disorders. In this regard, study investigated an animal model dopaminergic denervation nigrostriatal...
Neuroblastoma is the most common extracranial solid tumour in childhood, originated from cells of neural crest during development Sympathetic Nervous System. Retinoids are vitamin-A derived differentiating agents utilised to avoid disease resurgence high-risk neuroblastoma treatment. Several studies indicate that hypoxia-a feature tumoural environment-is a key player cell differentiation and proliferation. Hypoxia leads accumulation hypoxia-inducible factor-1α (HIF-1α). This work aims...
The receptor for advanced glycation end products (RAGE) is a multi-ligand receptor, which activation amplifies and perpetuates inflammatory reactions. RAGE also strongly stimulates the production of reactive oxygen species, leading an imbalance redox cellular state. extent liver damage caused by inflammation crucial to systemic response during proinflammatory episodes. To investigate role in inflammation, we evaluated effect blocking oxidative stress parameters induced lipopolysaccharide...
Abstract Astrogliosis comprises a variety of changes in astrocytes that occur context-specific manner, triggered by temporally diverse signaling events vary with the nature and severity brain insults. However, most mechanisms underlying astrogliosis were described using animal models, which fail to reproduce some aspects human astroglial signaling. Here, we report an vitro model study induced pluripotent stem cells (iPSC)-derived replicates intertwined reactive vivo . We analyzed time course...