A5044813333- Pesticide Residue Analysis and Safety
- Antibiotics Pharmacokinetics and Efficacy
- Pharmaceutical and Antibiotic Environmental Impacts
- Pharmacological Effects and Assays
- Insect and Pesticide Research
- Analytical Methods in Pharmaceuticals
- Helminth infection and control
- Bacterial Identification and Susceptibility Testing
- Plant Toxicity and Pharmacological Properties
- Salmonella and Campylobacter epidemiology
- Analytical chemistry methods development
- Phytochemicals and Antioxidant Activities
- Animal Nutrition and Physiology
- Adenosine and Purinergic Signaling
- Pesticide Exposure and Toxicity
- Forensic Toxicology and Drug Analysis
- Viral gastroenteritis research and epidemiology
- Pneumonia and Respiratory Infections
- Milk Quality and Mastitis in Dairy Cows
- Analytical Chemistry and Chromatography
- Essential Oils and Antimicrobial Activity
- Neurotransmitter Receptor Influence on Behavior
- Pain Mechanisms and Treatments
- Phytoestrogen effects and research
- Identification and Quantification in Food
Ministry of Agriculture, Livestock, and Food Supply
2014-2024
Ministério da Agricultura
2013-2024
Abcam (United States)
2021
Universidade Federal de Roraima
2021
Universidade Federal do Rio Grande do Sul
2005-2017
Instituto Nacional de Investigaciones Agropecuarias
2013
Universidade Federal do Rio Grande
2012
Universidade Federal de Sergipe
2010
Antibiotics are widely used in veterinary medicine mainly for treatment and prevention of diseases. The aminoglycosides one the antibiotics classes that have been extensively employed animal husbandry bacterial infections, but also as growth promotion. European Union has issued strict Maximum Residue Levels (MRLs) several origin products including bovine milk, bovine, swine poultry muscle. This paper describes a fast simple analytical method determination ten (spectinomycin, tobramycin,...
In residue analysis of veterinary drugs in foodstuff, matrix effects are one the most critical points. This work present a discuss considering approaches used to estimate, minimize and monitoring bioanalytical methods. Qualitative quantitative methods for estimation such as post-column infusion, slopes ratios analysis, calibration curves (mathematical statistical analysis) control chart discussed using real data. Matrix varying wide range depending analyte sample preparation method:...
A fast and simple method was developed to determine pyrrolizidine alkaloids (PAs) in honey using liquid chromatography tandem mass spectrometry (LC- MS/MS) with electrospray ionization (ESI). An efficient extraction procedure carried out by simply diluting water, without the need of any additional clean-up steps. full validation performed according Commission Decision 2002/657/EC. The linear 050 μg kg−1 range presented satisfactory intra-day inter-day precision relative standard deviations...
Citronellal is a monoterpene reported to be major component of the essential oils in various aromatic species plants. The present study evaluated central nervous system depressant and antinociceptive properties citronellal through behavioral experimental models. Following intraperitoneal injection, induced reduction spontaneous activity, ataxia, analgesia, sedation. In pentobarbital-induced hypnosis, CTL (citronellal) at 50, 100, 200 mg/kg (i.p.) significantly increased sleeping time (88.0 ±...
A simple and inexpensive sample preparation method based on solvent extraction, followed by low temperature cleanup, was demonstrated to be applicable for the determination of avermectin milbemycin residues in bovine muscle liquid chromatography-tandem mass spectrometry (LC-MS/MS) chromatography with fluorescence (LC-FL) detection. The analytical methodology validated according Commission Decision 2002/657/EC, using LC-MS/MS confirmatory LC-FL quantitative purposes. Mean recovery between...
The goal of this work is to study the presence 17 different pyrethroids and chlorpyrifos in animal origin food samples, including chicken, beef, fish, eggs milk. samples were analyzed by GC/NCI-MS/MS order determine their insecticide concentration levels, relation between amount insecticides lipid content, as well isomeric composition. Bifenthrin, cypermethrin, cyhalothrin, permethrin, deltamethrin have been detected real samples. highest levels find verified for (45.7 μg L−1, 17.5 kg−1 ww)...
This study presents the development and validation of a simple method for detection quantification six β-lactam antibiotics residues (ceftiofur, penicillin G, V, oxacillin, cloxacillin dicloxacillin) in bovine milk using fast liquid-liquid extraction (LLE) sample preparation, followed by liquid chromatography-electrospray-tandem mass spectrometry (LC-MS/MS). LLE consisted addition acetonitrile to sample, sodium chloride, centrifugation direct injection an aliquot into LC-MS/MS system....
Antibacterials are widely used in veterinary medicine. Residues of these drugs can remain food animal origin, including bovine liver. This paper describes a fast and simple analytical method for the determination quinolones fluoroquinolones, tetracyclines sulfonamides liver samples. Deuterated enrofloxacin, sulfapyridine demeclocycline were as internal standards. The homogenised samples extracted with acidified acetonitrile. Steps non-solid-phase extraction (SPE) clean-up concentration...
A multiresidue and multiclass method based on liquid chromatography-tandem mass spectrometry for the determination of antibacterials was developed validated screening purposes. This can be applied to commonly used drugs in veterinary medicine such as tetracyclines, quinolones sulfonamides. Sample preparation consists cell disruption with sand (previously purified washed EDTA 100 mM) followed by protein precipitation acidified acetonitrile. Validation conducted accordance European Union...
A reliable, simple and sensitive liquid chromatography–electrospray ionisation-tandem mass spectrometry (LC–ESI-MS/MS) confirmation method has been developed for chloramphenicol (CAP) determination in honey, fish prawns. For samples were extracted with ethyl acetate, an aliquot was evaporated to dryness re-dissolved mobile phase. prawns, tissues acetonitrile chloroform. The organic layer the residue re-constituted water: (90:10). LC separation achieved on a C18 column gradient elution using...
Abstract Schizophrenia (SCZ) response to pharmacological treatment is highly variable. Quetiapine (QTP) administered as QTP lipid core nanocapsules (QLNC) has been shown modulate drug delivery the brain of SCZ phenotyped rats (SPR). In present study, we describe concentration–effect relationship after administrations a solution or QLNC SPR and naïve animals. A semimechanistic pharmacokinetic (PK) model describing free concentrations in was linked pharmacodynamic (PD) correlate kinetics...