A5066799379- Vitamin C and Antioxidants Research
- Advanced Glycation End Products research
- Sepsis Diagnosis and Treatment
- Cardiovascular Function and Risk Factors
- Cardiac Ischemia and Reperfusion
- Cardiovascular Disease and Adiposity
- Healthcare Systems and Technology
- Cardiac Fibrosis and Remodeling
- MicroRNA in disease regulation
- Immune Response and Inflammation
- Cardiovascular and exercise physiology
- Folate and B Vitamins Research
- Phytochemistry Medicinal Plant Applications
- Antioxidant Activity and Oxidative Stress
- Healthcare Regulation
- Circular RNAs in diseases
- Cardiac pacing and defibrillation studies
- Adipose Tissue and Metabolism
- Diet and metabolism studies
- Liver Disease and Transplantation
- Cardiovascular Effects of Exercise
- Atherosclerosis and Cardiovascular Diseases
- Heart Failure Treatment and Management
- Anesthesia and Neurotoxicity Research
- Biochemical effects in animals
Universidade Federal do Rio Grande do Sul
2013-2024
Hospital de Clínicas de Porto Alegre
2015-2024
Hospital de Clínicas
2021
Universidade do Extremo Sul Catarinense
2003-2010
University of Rio Grande and Rio Grande Community College
2010
Pontifícia Universidade Católica do Rio Grande do Sul
2005
Pontifícia Universidade Católica de Minas Gerais
2001
Oxidative stress plays an important role in the development of multiple organ failure and septic shock. Here we have evaluated effects a combination antioxidants (N-acetylcysteine plus deferoxamine) murine model polymicrobial sepsis induced by cecal ligation puncture (CLP).Prospective, randomized, controlled experiment.Animal basic science laboratory.Male Wistar rats, weighing 300-350 g.Rats subjected to CLP were treated with either N-acetylcysteine (20 mg/kg, 3 hrs, 6 12 18 24 hrs after...
Interleukin-6 (IL-6) plays a central role in atherosclerosis and inflammation. It may improve risk prediction patients at intermediate cardiovascular risk. To analyze the impact of serum IL-6 predicting early angiographic coronary artery disease with chest pain. In cross-sectional study, referred for angiography due to suspected (CAD) were included. Coronary was defined as presence least 30% stenosis one or more artery. Severity CAD classified by anatomic burden score. Performance assay...
The association between physical exercise and oxidative damage in the skeletal musculature has been focus of many studies literature, but balance superoxide dismutase catalase activities its relation to is not well established. Thus, aim present study was investigate regular treadmill exercise, antioxidant defenses muscle rats. Fifteen male Wistar rats (8-12 months) were randomly separated into two groups (trained n=9 untrained n=6). Trained treadmill-trained for 12 weeks progressive...
Objectives: Interventions that reduce the generation or effects of reactive oxygen species exert controversial in animal models lung injury, and these could be secondary to pro-oxidant antioxidants generally by their interaction with iron. We here describe N-acetylcysteine, deferoxamine, both treatment acute injury induced intratracheal lipopolysaccharide injection. Design: Prospective, randomized, controlled experiment. Setting: Animal basic science laboratory. Subjects: Male Wistar rats,...
Background MicroRNAs (miRs) are a class of small non-coding RNAs that regulate gene expression. Studies transgenic mouse models have indicated deregulation single miR can induce pathological cardiac hypertrophy and failure. The roles miRs in the genesis physiological left ventricular (LVH), however, not well understood. Objective To evaluate global expression an experimental model exercise-induced LVH. Methods Male Balb/c mice were divided into sedentary (SED) exercise (EXE) groups....
Interleukin-6 (IL-6) is an inflammation-related cytokine associated with elevated risk of cardiovascular events. In a previous study, we demonstrated that increased IL-6 was predictive sub-clinical atherosclerotic coronary disease in intermediate-risk patients undergoing angiography. the present investigated whether serum events high-risk patients.In this observational consecutive referred for elective angiography due to stable chest pain/myocardial ischemia had measured immediately before...
Carbon tetrachloride (CCl4) is a lipid-soluble potent hepatotoxic; thus, it widely used as an animal model of severe hepatic failure. Treatment with antioxidants may modulate the toxic effects CCl4 on liver, generally drug administration before CCl4, which can restrict its use in clinical setting. We here describe N-acetylcysteine, deferoxamine, or both treatment CCl4-induced failure.Prospective, randomized, controlled experiment.Animal basic science laboratory.Male Wistar rats, weighing...
Objective: To investigate serum levels and genetic polymorphisms of matrix metalloproteinases (MMPs) -1, -3 -9 in patients submitted to carotid endarterectomy.
Context: Elevated plasmatic microRNAs (miRs) are observed in heart failure (HF). However, the cardiac origin of these miRs remains unclear.Objective: We calculated transcoronary gradients miR-29b, miR-133a and miR-423-5p 17 outpatients with stable systolic HF controls without structural disease.Materials methods: MicroRNAs were measured by quantitative real-time polymerase chain reaction.Results: Positive miR patients but not (p = 0.03). B-type natriuretic peptide (BNP) moderately correlated...
Several new therapeutic strategies have been described for the treatment of sepsis, but to date none are related alterations in bombesin/gastrin-releasing peptide (GRP) receptor pathways.To determine effects a selective GRP antagonist, RC-3095, on cytokine release from macrophages and its vivo cecal ligation puncture (CLP) model sepsis acute lung injury induced by intratracheal instillation LPS.We determined RC-3095 CLP LPS. In addition, we tumor necrosis factor-alpha (TNF-alpha),...
MicroRNAs are associated with myocardial damage and heart failure (HF). The present study investigated whether the plasma levels of microRNA (miR)‑21, ‑126 ‑423‑5p alter according to (de)compensated state patients HF all‑cause mortality. In 48 admitted emergency room for an episode acute decompensation, blood samples were collected measure miR B‑type natriuretic peptide within 24 h hospital admission, at time discharge, a number weeks post‑discharge (chronic stable compensated state). Levels...