A5068072218- Metabolism and Genetic Disorders
- Diet and metabolism studies
- Folate and B Vitamins Research
- Neuroscience and Neuropharmacology Research
- Mitochondrial Function and Pathology
- Urinary Tract Infections Management
- COVID-19 Clinical Research Studies
- Amino Acid Enzymes and Metabolism
- Palliative and Oncologic Care
- Birth, Development, and Health
- SARS-CoV-2 and COVID-19 Research
- Diet, Metabolism, and Disease
- Healthcare during COVID-19 Pandemic
- Muscle and Compartmental Disorders
- Long-Term Effects of COVID-19
- Semantic Web and Ontologies
- Biochemical effects in animals
- Plant Virus Research Studies
- Reproductive System and Pregnancy
- Adipose Tissue and Metabolism
- Fatty Acid Research and Health
- Blood donation and transfusion practices
- Acute Myeloid Leukemia Research
- Effects and risks of endocrine disrupting chemicals
- Coenzyme Q10 studies and effects
Universidade Federal de Ciências da Saúde de Porto Alegre
2015-2024
Universidade Luterana do Brasil
2002-2009
Universidade Federal do Rio Grande do Sul
1999-2009
Universidade Federal de Santa Catarina
2007-2009
Fundação Faculdade de Medicina
2007-2008
Pontifícia Universidade Católica do Rio Grande do Sul
2002
Ocní klinika
1992
S100B is a 21-kDa calcium-binding protein produced and released primarily by astrocytes in the central nervous system (CNS), where it exerts neurotropic gliotropic actions (1). Several studies have investigated potential role of as peripheral biochemical marker neural injury, including reactive gliosis, astrocytic death, and/or blood-brain barrier dysfunction (2). Increased cerebrospinal fluid (CSF) serum has been reported several acute chronic injuries, traumatic brain injury (3), stroke...
Background P.1 lineage (Gamma) was first described in the State of Amazonas, northern Brazil, end 2020, and has emerged as a very important variant concern (VOC) SARS-CoV-2 worldwide. been linked to increased infectivity, higher mortality, immune evasion, leading reinfections potentially reduced efficacy vaccines neutralizing antibodies. Methods The samples 276 patients from Amazonas were sent central referral laboratory for sequencing by gold standard techniques, through Illumina MiSeq...
Abstract: The aim of the present study was to investigate effect intraperitoneal administration caffeic acid (0.5, 1, 2, 4 or 8 mg/kg) on elevated plus‐maze and open field tasks in rats its possible neuroprotection/neurotoxicity using comet assay. Caffeic at 1 mg/kg increased number entries time spent arms plus‐maze, suggesting an anxiolytic‐like when used lower doses without affecting locomotion exploration field. Furthermore, a protective against hydrogen peroxide‐induced oxidative damage...
Abstract Background Our goal was to analyze the association of fat mass and obesity- associated (FTO) gene rs9939609 variant (T/A) with anthropometric dietary intake phenotypes related obesity in Brazilian children. Methods We analyzed this single nucleotide polymorphism (SNP) accumulation body a cohort 348 children followed from time birth until 8 years old then replicated main findings an independent schoolchildren sample (n = 615). Results At age 4, we observed significant between A/A...
To evaluate urinalysis parameters useful for identifying mixed cultures in urine culture using an automated urinary particle analyzer to assess quality indicators (QIs) sample contamination.
Many studies have demonstrated that DNA damage may be associated with type 2 diabetes mellitus (T2DM) and its complications. The goal of this study was to evaluate the effects potential relationship between fat (thermolyzed) intake, glucose dyshomeostasis injury in rats. Biochemical parameters related metabolism (i.e., blood levels, insulin tolerance tests, tests cell oxidation) general health body weight, retroperitoneal epididymal adipose tissue) were evaluated rats after a 12-month...
The ketogenic diet (KD), characterized by high fat and low carbohydrate protein contents, has been proposed to be beneficial in children with epilepsy disorders not helped conventional anti-epileptic drug treatment. Weight loss inadequate growth is an important drawback of this metabolic causes are well characterized. aim study was examine body weight variation during KD feeding for 6 wk Wistar rats; mass adipocyte cytosolic phosphoenolpyruvate carboxykinase (PEPCK) activity were also...
Recent studies indicate that caloric restriction (CR) protects the central nervous system from several pathological conditions. The impairment of astroglial cell function, including glutamate uptake, glutamine synthetase (GS) activity and S100B secretion, may contribute to progression neurological disorders. present study aimed evaluate hippocampal astrocytic changes in response CR diet, measuring parameters, such as GS immunocontent GFAP S100B. Blood biochemical parameters were also...
S100B is a calcium-binding protein expressed and secreted by astrocytes, playing neurotrophic role in neighboring cells. A protective of the against glutamate-induced excitotoxicity has recently been proposed. We investigated secretion rat hippocampal astrocytes exposed to high concentrations glutamate during serum deprivation (stimulated condition) or not (basal condition), for 30 min. Glutamate at 1 mM had no effect on basal S100B, but it decreased serum-deprived after h. Secretion was...
Almost a year after the COVID-19 pandemic had begun, new lineages (B.1.1.7, B.1.351, P.1, and B.1.617.2) associated with enhanced transmissibility, immunity evasion, mortality were identified in United Kingdom, South Africa, Brazil. The previous most prevalent state of Rio Grande do Sul (RS, Southern Brazil), B.1.1.28 B.1.1.33, rapidly replaced by P.1 P.2, two B.1.1.28-derived harboring E484K mutation. To perform genomic characterization from metropolitan region Porto Alegre, we sequenced...
Nutrition during pregnancy and lactation can program an offspring's metabolism with regard to glucose lipid homeostasis. A suboptimal environment fetal, neonatal infant development is associated impaired tolerance, type 2 diabetes insulin resistance in later adult life. However, studies on the effects of a low protein diet imposed from beginning gestation until adulthood are scarce. This study's objective was investigate gestational period 4 months age parameters tolerance responsiveness...
Acute and chronic kidney dysfunction is common in patients with end-stage liver disease. Differentiation between acute injury (AKI) due to hepatorenal syndrome (HRS) or tubular necrosis (ATN) remains difficult, however urine cast scoring systems using renal epithelial cells (RTECs) granular casts (GCs) can help identify intrinsic diseases. The objective of this study was evaluate the sediment profile disease hyperbilirubinemia/hyperbilirubinuria use a system most score AKI high bilirubin...