A5074491565- Pulsars and Gravitational Waves Research
- Gamma-ray bursts and supernovae
- Radio Astronomy Observations and Technology
- Geophysics and Gravity Measurements
- Astrophysical Phenomena and Observations
- Advanced biosensing and bioanalysis techniques
- Astrophysics and Cosmic Phenomena
- CRISPR and Genetic Engineering
- High-pressure geophysics and materials
- DNA Repair Mechanisms
- Particle accelerators and beam dynamics
- Protein Degradation and Inhibitors
- RNA and protein synthesis mechanisms
- Genomics and Chromatin Dynamics
- Stellar, planetary, and galactic studies
- Cosmology and Gravitation Theories
Leiden University Medical Center
2024-2025
Xinjiang Astronomical Observatory
2020-2024
Chinese Academy of Sciences
2021-2024
University of Chinese Academy of Sciences
2020-2022
Xinjiang University
2019
Abstract We report the timing analysis of PSR J1846−0513, a pulsar discovered by Five-hundred-meter Aperture Spherical radio Telescope (FAST) in Commensal Radio Astronomy FAST Survey. The possesses spin period 23.36 ms and spin-down rate ( <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" overflow="scroll"> <mml:mover accent="true"> <mml:mrow> <mml:mi>P</mml:mi> </mml:mrow> <mml:mo>̇</mml:mo> </mml:mover> </mml:math> ) 1.0106(3) × 10 −18 s −1 , it is located an eccentric orbit e...
Abstract The functions of non-coding regulatory elements (NCREs), which constitute a major fraction the human genome, have not been systematically studied. Here we report method involving libraries paired single-guide RNAs targeting both ends an NCRE as screening system for Cas9-mediated deletion thousands NCREs genome-wide to study their in distinct biological contexts. By using K562 and 293T cell lines embryonic stem cells, show that can redundant functions, many ultra-conserved silencer...
CRISPR (clustered regularly interspaced short palindromic repeats) technology has revolutionized both fundamental research and genomic medicine. The need for precise control of SpCas9-based genome editing resulted in a number methods to the function activity Cas9 proteins minimize off-target effects. Proteolysis-targeting chimeras (PROTACs) are an emerging using ubiquitin-proteasome system selectively degrade target proteins. Here, we developed CASPROTAC 6, reversible cell-permeable degrader...
Abstract We present polarization profiles of 23 pulsars exhibiting interpulse (IP) emissions using the Five-hundred-meter Aperture Spherical Radio Telescope. By applying rotating vector model (RVM), we measured inclination and impact angles for 16 pulsars, allowing us to investigate their beam geometries. Our analysis indicates that five IP likely originate from same magnetic pole as main pulse (MP), whereas remaining 11 MP opposite poles. For seven do not conform RVM, are unable determine...
ABSTRACT The follow-up timing observations were carried out for 24 pulsars discovered with the Five-hundred-meter Aperture Spherical radio Telescope (FAST) in Commensal Radio Astronomy FAST Survey. We report their phase-connected ephemeris, polarization pulse profiles, and Faraday rotation measurements. With spin periods spanning from 2.995 ms to 4.34 s, period derivatives determined spread between 7.996(8) × 10−21 9.83(3) 10−15 s s−1, which imply that they have characteristic ages 1.97 106...
Abstract PSR J2150+3427 is a 0.654 s pulsar discovered by the Commensal Radio Astronomy FAST Survey. From follow-up observations, we find that in highly eccentric orbit ( e = 0.601) with an orbital period of 10.592 days and projected semimajor axis 25.488 lt-s. Using 2.7 yr timing data, also measured rate periastron advance <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" overflow="scroll"> <mml:mover accent="true"> <mml:mrow> <mml:mi>ω</mml:mi> </mml:mrow> <mml:mo>̇</mml:mo>...
We report the emission variations in PSR J1047$-$6709 observed at 1369 MHz using Parkes 64 m radio telescope. This pulsar shows two distinct states: a weak state and bright state. detected giant pulses (GPs) for first time. found 75 GPs with pulse width ranging from 0.6 to 2.6 ms. The energy of follows power-law distribution index $\alpha=-3.26\pm0.22$. peak flux density brightest GP is 19 Jy which 110 times stronger than mean profile. polarization properties average profile are similar that...
Abstract Rotating Radio Transients are a relatively new subclass of pulsar characterized by sporadic bursting emission single pulses. Here, we present single-pulse analysis rotating radio transient, RRAT J0139+3336, using Five-hundred-meter Aperture Spherical Telescope at 1250 MHz. Within 3.32 hr continuous observation, 152 pulses were detected in with the pulse rate 45 per hour. We perform spectral on this for first time, finding its mean indices to be −3.2 ± 0.2, which is steeper than most...
Abstract We present phase-connected timing ephemerides, polarization pulse profiles, and Faraday rotation measurements of 12 pulsars discovered by the Five-hundred-meter Aperture Spherical radio Telescope (FAST) in Commensal Radio Astronomy FAST Survey. The observational data for each pulsar span at least 1 yr. Among them, PSR J1840+2843 shows subpulse drifting, five are detected to exhibit nulling phenomena. J0640−0139 J2031−1254 isolated millisecond (MSPs) with stable spin-down rates (...
Abstract We presented observations of PSRs J0614+2229 and J1938+2213 using the Five-hundred-meter Aperture Spherical radio Telescope. PSR shows two distinct emission states, in which state A occurs earlier than that B longitude. The phase offset between average pulse profile peaks states is about 1.°05. polarization properties are different with linear position angle swings. found becomes brighter during transition has never been seen other mode-changing pulsars before. appears to consist a...
The single pulse observation of PSR J1752+2359 at 1250 MHz made using the Five-hundred-meter Aperture Spherical radio Telescope (FAST) is presented. We show that pulsar exhibits two distinct emission states: a normal state with continuous and rotating transient (RRAT)-like sporadic emission. This makes third switching between RRAT-like pulsar-like states. Our data that, during observation, 20 per cent time for this was in 80 state. A quasi-periodic switching, periodicity around 568 spin...
Abstract We present a polarization analysis of PSR J0941–39 and J1107–5907, which exhibit transitions between being pulsars rotating radio transients (RRATs), using the ultrawide-bandwidth low-frequency receiver on Murriyang, Parkes 64 m telescope. The spectral index each pulsar was measured, revealing distinct variations among different states. By vector model, we determined that geometry magnetosphere remains consistent RRAT state for J0941–39, with emissions originating from same height...
In this paper, we presented a detailed single pulse and polarization study of PSR J0614+2229 based on the archived data observed 2019 August 15 (MJD 58710) September 12 58738) using Ultra-wideband Low-frequency Receiver Parkes radio telescope. The single-pulse sequences show that pulsar switches between two emission states, in which state A occurs earlier than B longitude. We found variation relative brightness states is related to time both follow simple power law very well. Based...
Abstract In this paper we present a detailed single-pulse and polarization study of PSR J0614+2229 based on the archived data observed 2019 August 15 (MJD 58710) September 12 58738) using ultra−wide-bandwidth low-frequency receiver Parkes radio telescope. The sequences show that pulsar switches between two emission states, in which state A occurs earlier than B pulse longitude. We found variation relative brightness states varies temporally both follow simple power law very well. Based...
Abstract The chromatins are folded into three-dimensional (3D) structures inside cells, which coordinates the regulation of gene transcription by non-coding regulatory elements. Aberrant chromatin 3D folding has been shown in many diseases, such as acute myeloid leukemia (AML), and may contribute to tumorigenesis. anthracycline topoisomerase II inhibitors can induce histone eviction DNA damage. We performed genome-wide high-resolution mapping chemotherapeutic effects various clinically used...
We present phase-connected timing ephemerides, polarization pulse profiles and Faraday rotation measurements of 12 pulsars discovered by the Five-hundred-meter Aperture Spherical radio Telescope (FAST) in Commensal Radio Astronomy FAST Survey (CRAFTS). The observational data for each pulsar span at least one year. Among them, PSR J1840+2843 shows subpulse drifting, five are detected to exhibit nulling phenomena. J0640$-$0139 J2031$-$1254 isolated MSPs with stable spin-down rates ($\dot{P}$)...
Abstract This paper uses population synthesis to investigate the possible origin of isolated millisecond pulsars as born from coalescence a neutron star and white dwarf. Results show that galactic birth rate is likely lie between 5.8×10 −5 yr −1 2.0×10 −4 , depending on critical variables, such stability mass transfer via Roche lobe value kick velocity. In addition this, this estimates solar can range 1.5 2.0 M ʘ making them more massive than other ‘normal’ pulsars. Finally, majority in our...
We present a polarization analysis of PSR J0941$-$39 and J1107$-$5907, which exhibit transitions between being pulsars rotating radio transients (RRATs), using the ultra-wide bandwidth low-frequency (UWL) receiver on Murriyang, Parkes 64\,m telescope. The spectral index each pulsar was measured, revealing distinct variations among different states. By vector model (RVM), we determined that magnetosphere geometry remains consistent RRAT state for J0941$-$39, with emissions originating from...