A5100375333- Statistical Methods and Inference
- Statistical Methods in Clinical Trials
- COVID-19 epidemiological studies
- Statistical Methods and Bayesian Inference
- Advanced Causal Inference Techniques
- Point processes and geometric inequalities
- COVID-19 diagnosis using AI
- Acute Myeloid Leukemia Research
- Immune Cell Function and Interaction
- Non-Invasive Vital Sign Monitoring
- Immunodeficiency and Autoimmune Disorders
- Differential Equations and Boundary Problems
- Navier-Stokes equation solutions
- Differential Equations and Numerical Methods
- Cancer Genomics and Diagnostics
- Statistical Distribution Estimation and Applications
- Pharmacological Effects of Medicinal Plants
- Immunotherapy and Immune Responses
- COVID-19 and Mental Health
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Pandemic Impacts
- Blood disorders and treatments
- Lung Cancer Diagnosis and Treatment
- Health Systems, Economic Evaluations, Quality of Life
- Cancer Immunotherapy and Biomarkers
Shanghai Jiao Tong University
2013-2025
Shanghai Mental Health Center
2025
Case Western Reserve University
2020-2024
Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine
2024
Chongqing Normal University
2023
Medical College of Wisconsin
2023
Stanford University
2017-2022
Yan'an Hospital Affiliated To Kunming Medical University
2022
Western University of Health Sciences
2020-2022
University School
2022
A new wave of portable biosensors allows frequent measurement health-related physiology. We investigated the use these devices to monitor human physiological changes during various activities and their role in managing health diagnosing analyzing disease. By recording over 250,000 daily measurements for up 43 individuals, we found personalized circadian differences parameters, replicating previous findings. Interestingly, striking particular environments, such as airline flights (decreased...
Abstract Early detection of infectious diseases is crucial for reducing transmission and facilitating early intervention. In this study, we built a real-time smartwatch-based alerting system that detects aberrant physiological activity signals (heart rates steps) associated with the onset infection implemented in prospective study. cohort 3,318 participants, whom 84 were infected severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), generated alerts pre-symptomatic asymptomatic...
ObjectiveTo estimate the economic cost of coronavirus disease 19 (COVID-19) in 31 provincial-level administrative regions and total, China.Methods We used data from government reports, clinical guidelines other publications to main components COVID-19 during 1 January-31 March 2020.These were: identification diagnosis close contacts; suspected cases confirmed COVID-19; treatment cases; compulsory quarantine contacts productivity losses for all affected residents.Primary outcomes were total...
Abstract CTLA-4 is an important regulator of T-cell function. Here, we report that expression this immune-regulator in mouse B-1a cells has a critical function maintaining self-tolerance by regulating these early-developing B express repertoire enriched for auto-reactivity. Selective deletion from results mice spontaneously develop autoantibodies, T follicular helper (Tfh) and germinal centers (GCs) the spleen, autoimmune pathology later life. This impaired immune homeostasis cell...
Abstract The large amount of biomedical data derived from wearable sensors, electronic health records, and molecular profiling (e.g., genomics data) is rapidly transforming our healthcare systems. increasing scale scope not only generating enormous opportunities for improving outcomes but also raises new challenges ranging acquisition storage to analysis utilization. To meet these challenges, we developed the Personal Health Dashboard (PHD), which utilizes state-of-the-art security...
Increasing evidence suggests that intratumoral inflammation has an outsized influence on antitumor immunity. Here, we report IL-17, a proinflammatory cytokine widely associated with poor prognosis in solid tumors, drives the therapeutic failure of anti-PD-L1. By timing deletion IL-17 signaling specifically cancer-associated fibroblasts (CAFs) late-stage show immune exclusion by activating collagen deposition program murine models cutaneous squamous cell carcinoma (cSCC). Ablation CAFs...
Abstract Wearable devices digitally measuring vital signs have been used for monitoring health and illness onset high potential real-time disease detection. As such they are potentially useful during public crises, as the current COVID-19 global pandemic. Using smartwatch data from 31 infected individuals identified a cohort of over 5000 participants, we investigated use wearables early, presymptomatic detection COVID-19. From physiological activity data, first demonstrate that infections...
Abstract The individual infectiousness of coronavirus disease 2019 (COVID-19), quantified by the number secondary cases a typical index case, is conventionally modelled negative-binomial (NB) distribution. Based on patient data 9120 confirmed in China, we calculated variation infectiousness, i.e., dispersion parameter k NB distribution, at 0.70 (95% confidence interval: 0.59, 0.98). This suggests that probably low, thus COVID-19 infection relatively easy to sustain population and more...
The novel coronavirus disease (COVID-19) poses a serious threat to global public health and economics. Serial interval (SI), time between the onset of symptoms primary case secondary case, is key epidemiological parameter. We estimated SI COVID-19 in Shenzhen, China based on 27 records transmission chains. adopted three parametric models: Weibull, lognormal gamma distributions, an interval-censored likelihood framework. models were compared using corrected Akaike information criterion...
Abstract The functions of non-coding regulatory elements (NCREs), which constitute a major fraction the human genome, have not been systematically studied. Here we report method involving libraries paired single-guide RNAs targeting both ends an NCRE as screening system for Cas9-mediated deletion thousands NCREs genome-wide to study their in distinct biological contexts. By using K562 and 293T cell lines embryonic stem cells, show that can redundant functions, many ultra-conserved silencer...
Abstract Death represents the end of all living organisms. The pattern brain activity disappearance following death, however, has not been fully elucidated. Here we investigated dynamics cardiac arrest using ultra‐high field 11.7 T magnetic resonance imaging (MRI) in longitudinal approach and multi‐modal analyses. Initially, functional connectivity (FC) analysis revealed a non‐linear trajectory whole‐brain network disassembly. Subsequently, through dynamic FC analysis, identified two...
Even though postoperative chemotherapy can eliminate residual tumor cells in patients with colorectal cancer (CRC), severe adversity, weakened immunity and drug resistance are still problems. Adjuvant cytokine-induced killer (CIK) cell therapy is an alternative to CRC after surgery. The present study investigated the efficacy of adjuvant CIK combined patients.This retrospective analysis included 137 patients, including 71 who received alone (control group) 66 immunotherapy based on (CIT...
To provide biologic insights into mechanisms underlying myelodysplastic syndromes (MDS) we evaluated the CD34+ marrow cells transcriptome using high-throughput RNA sequencing (RNA-Seq). We demonstrated significant differential gene expression profiles (GEPs) between MDS and normal identified 41 disease classifier genes. Additionally, two main clusters of GEPs distinguished patients based on their major clinical features, particularly those whose remained stable versus who transformed acute...
Objective. The aim of this study was to compare the accuracy and efficacy sonographically guided lumbar periradicular injections through in-plane or out-of-plane approach techniques for patients with unilateral lower radicular pain. feasibility these were studied by means computed tomography (CT). Methods. A total 46 chronic pain recruited randomly assigned either injection group. mixture 3 mL 1% lidocaine 7 mg betamethasone injected. visual analog scale (VAS) used assess before after...
A pterygium is generally believed to be a chronic inflammatory lesion caused by external stimuli that develops from the conjunctiva and grows onto cornea. Simple bare sclera excision most commonly used method treat pterygium. However, high postoperative recurrence rate of remains persistent challenge. Mitomycin C (MMC) an antineoplastic antibiotic inhibits DNA, RNA, protein synthesis. In recent years, although MMC has proven useful for treatment pterygium, its application been controversial...
ABSTRACT We develop a method for hybrid analyses that uses external controls to augment internal control arms in randomized controlled trials (RCTs) where the degree of borrowing is determined based on similarity between RCT and patients account systematic differences (e.g., unmeasured confounders). The represents novel extension power prior discounting weights are computed separately each compatibility with data. using predictive distribution derived via posterior time-to-event parameters...
Increased autoantibody reactivity in plasma from Myelodysplastic Syndromes (MDS) patients may provide novel disease signatures and possible early detection. In a two-stage study we investigated Immunoglobulin G MDS, Acute Myeloid Leukemia post MDS healthy cohort. exploratory Stage I utilized high-throughput protein arrays to identify 35 high-interest proteins showing increased patient subgroups compared controls. validation II designed new focusing on 25 of the identified expanded initial We...