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Contact & Profiles
A5098757942
Research Areas
- RNA and protein synthesis mechanisms
- Advanced biosensing and bioanalysis techniques
- CRISPR and Genetic Engineering
Leiden University Medical Center
2024
Abstract The functions of non-coding regulatory elements (NCREs), which constitute a major fraction the human genome, have not been systematically studied. Here we report method involving libraries paired single-guide RNAs targeting both ends an NCRE as screening system for Cas9-mediated deletion thousands NCREs genome-wide to study their in distinct biological contexts. By using K562 and 293T cell lines embryonic stem cells, show that can redundant functions, many ultra-conserved silencer...
10.1038/s41551-024-01204-8
article
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Nature Biomedical Engineering
2024-05-22
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