A5040448271- Chronic Lymphocytic Leukemia Research
- Protein Degradation and Inhibitors
- Streptococcal Infections and Treatments
- Viral Infectious Diseases and Gene Expression in Insects
- Advanced Breast Cancer Therapies
- Phagocytosis and Immune Regulation
- Cardiac Valve Diseases and Treatments
- DNA Repair Mechanisms
- Surgical Sutures and Adhesives
- Histone Deacetylase Inhibitors Research
- PARP inhibition in cancer therapy
- Cancer-related Molecular Pathways
- Cancer-related gene regulation
- Genital Health and Disease
- Wound Healing and Treatments
- CAR-T cell therapy research
- Surgical site infection prevention
- Chronic Myeloid Leukemia Treatments
- Microfluidic and Bio-sensing Technologies
- Entomological Studies and Ecology
- Myasthenia Gravis and Thymoma
- Cardiac Structural Anomalies and Repair
- Urologic and reproductive health conditions
- Biliary and Gastrointestinal Fistulas
- Vascular anomalies and interventions
The Ohio State University
2018-2024
Government Medical College
2018
Boehringer Ingelheim (United States)
2017
Malankara Orthodox Syrian Church Medical College Hospital
2014
Father Muller Medical College Hospital
2005-2007
Achievement of a robust and scalable cell retention device remains challenge in perfusion systems. Of the two filtration systems commonly used, tangential flow (TFF) often have an inferior product sieving profile compared to alternating (ATF) systems, which is typically attributed ATF’s unique flow. Here, we demonstrate that observed performance differences between are function lysis not as previously thought. The peristaltic pump used typical TFF shown be single major contributor shear...
Chronic lymphocytic leukemia (CLL) is effectively treated with targeted therapies including Bruton tyrosine kinase inhibitors and BCL2 antagonists. When these become ineffective, treatment options are limited. Positive transcription elongation factor complex (P-TEFb), a heterodimeric protein composed of cyclin dependent 9 (CDK9) T1, functions to regulate short half-life transcripts by phosphorylation RNA Polymerase II (POLII). These frequently dysregulated in hematologic malignancies;...
Successes with anti-CD20 antibodies in chronic lymphocytic leukemia (CLL) and enhanced activity of Fc-engineered vs unmodified antibody therapy suggest a potentially impactful role for natural killer (NK) cells other innate immune controlling this disease. Stimulated NK have shown promise as cellular therapy, but their application has been constrained by limited expansion capacity low cytotoxic against CLL cells. Here, we demonstrate that both healthy donor-derived patient-derived expand...
Perfusion processes typically require removal of a continuous or semi-continuous volume cell culture in order to maintain desired target density. For fast growing lines, the product loss from this stream can be upwards 35%, significantly reducing overall process yield. As removed is directly proportional growth, ability modulate growth during perfusion production thus becomes crucial. Leveraging existing media components achieve such control without introducing additional supplements most...
Abstract Chronic lymphocytic leukemia (CLL) is a quiescent B-cell malignancy that depends on transcriptional dysregulation for survival. The histone deacetylases are regulators whose role within the regulatory chromatin and consequence CLL transcriptome poorly characterized. Here, we profiled integrated genome-wide occupancy of HDAC1, BRD4, H3K27Ac, H3K9Ac signals with accessibility, Pol2 occupancy, target expression signatures in cells. We identified when HDAC1 was recruited super-enhancers...
Patients with chronic lymphocytic leukemia (CLL) respond well to initial treatment the Bcell lymphoma 2 (BCL2) inhibitor venetoclax. Upon relapse, they often retain sensitivity BCL2 targeting, but durability of response remains a concern. We hypothesize that targeting both and B-cell lymphoma-extra large (BCLXL) will be successful strategy treat CLL, including for patients who relapse on To test this hypothesis, we conducted pre-clinical investigation LP-118, highly potent moderate BCLXL...
Aim: To assess the efficacy of topical negative pressure moist wound dressing as compared to conventional dressings in improving healing process chronic wounds and prove that can be used a much better treatment option management wounds. Materials Methods: This is prospective comparative study data from 112 patients with wounds, which 56 underwent (17 diabetic, 10 sores, nine ischemic, two varicose, post-infective raw areas eight traumatic - six had bone exposed, orthopaedic prosthesis...
The presentation of leukemoid reaction in patients post-cardiac surgery is rare with limited prior reports the English language literature. We report a case raised leukocyte count no evidence infection patient post coronary artery bypass graft surgery. exaggerated inflammatory response by to extra-corporeal circulation was drastically elevated, but fell short leukaemoid definition – so we have defined it as like reaction. A clear correlation between and documented.
Fournier's gangrene is a rare, fulminant, though generally localized disease of the scrotum and penis with occasional extension up abdominal wall. The usual organism an anaerobic streptococcus synergistic some second organism. Our case was unusual in that only involved without involving or Early therapy key, including hospitalization, debridement entire shaft distal to devasted area excising normal skin, parenteral broad-spectrum antibiotics & skin grafting. Only few cases have been reported.
ABSTRACT Aim: To assess the efficacy of topical negative pressure moist wound dressing as compared to conventional dressings in improving healing process chronic wounds and prove that can be used a much better treatment option management wounds. Materials Methods: This is prospective comparative study data from 112 patients with wounds, which 56 underwent (17 diabetic, 10 sores, nine ischemic, two varicose, post-infective raw areas eight traumatic - six had bone exposed, orthopaedic...
BACKGROUND: Treatment of rheumatic mitral stenosis ranges from conservative medical management to closed valvotomy and the more recent balloon valvoplasty.This is a prospective study compare results with percutaneous valvoplasty in 100 cases (50 patients each group) non-calcific stenosis.MATERIALS AND METHODS: From November 2011 March 2012, 50 patient underwent another had valvoplasty.Balloon was performed by Inoue technique carried out through standard anterolateral thoracotomy...
Background: Cyclin dependent kinase 9 (CDK9) controls transcriptional elongation, its inhibition may be effective in controlling cancer. To date, no drugs specifically targeting CDK9 have been approved due to challenges with therapeutic window. VIP152 was designed a highly potent and selective inhibitor favorable pharmacokinetic (PK) pharmacodynamic (PD) effects improve efficacy patients lymphoma. Aims: - demonstrate the safety profile associated profile. utility of for treatment hematologic...
Abstract HDAC1 is a key regulator of gene expression in cancer. We identified critical role for establishing the transcriptional dependencies essential survival chronic lymphocytic leukemia (CLL) by profiling with BRD4, H3K27Ac superenhancers, H4K9Ac, chromatin accessibility signatures, Pol2 measurements and signatures to generate regulatory landscape. Superenhancers marked high levels acetylation BRD4 paradoxically also recruited highest HDAC1. HDAC inhibition poisoned transcription at...
ABSTRACT Fournier′s gangrene is a rare, fulminant, though generally localized disease of the scrotum and penis with occasional extension up abdominal wall. The usual organism an anaerobic streptococcus synergistic some second organism. Our case was unusual in that only involved without involving or Early therapy key, including hospitalization, debridement entire shaft distal to devasted area excising normal skin, parenteral broad-spectrum antibiotics & skin grafting. Only few cases have...