A5078572190- Alzheimer's disease research and treatments
- Genetics and Neurodevelopmental Disorders
- Trace Elements in Health
- Parkinson's Disease Mechanisms and Treatments
- Pesticide Exposure and Toxicity
- Nerve injury and regeneration
- Autophagy in Disease and Therapy
- Cancer-related Molecular Pathways
- Genomics and Rare Diseases
- Neurological diseases and metabolism
- Microtubule and mitosis dynamics
- RNA regulation and disease
- Neuroinflammation and Neurodegeneration Mechanisms
- Heavy Metal Exposure and Toxicity
- Neuroscience and Neuropharmacology Research
- Coenzyme Q10 studies and effects
- Cancer-related cognitive impairment studies
- Neurogenetic and Muscular Disorders Research
- Neurogenesis and neuroplasticity mechanisms
- Neurological disorders and treatments
- Tryptophan and brain disorders
- Cholinesterase and Neurodegenerative Diseases
- Computational Drug Discovery Methods
- MicroRNA in disease regulation
- Pain Mechanisms and Treatments
Institute of Genomics and Integrative Biology
2017-2025
Academy of Scientific and Innovative Research
2018-2025
Council of Scientific and Industrial Research
2022-2025
National Institute of Neurological Disorders and Stroke
2014-2019
National Institutes of Health
2013-2019
Centre for Chronic Disease Control
2015
Public Health Foundation of India
2015
Post Graduate Institute of Medical Education and Research
2010-2012
With the advent of next-generation sequencing, large-scale initiatives for mining whole genomes and exomes have been employed to better understand global or population-level genetic architecture. India encompasses more than 17% world population with extensive diversity, but is under-represented in sequencing datasets. This gave us impetus perform analyze genome 1029 healthy Indian individuals under pilot phase 'IndiGen' program. We generated a compendium 55,898,122 single allelic variants...
Long non-coding RNAs (lncRNAs) are emerging as key regulators of endothelial cell function. Here, we investigated the role a novel vascular endothelial-associated lncRNA (VEAL2) in regulating permeability. Precise editing veal2 loci zebrafish (veal2gib005Δ8/+ ) induced cranial hemorrhage. In vitro and vivo studies revealed that competes with diacylglycerol for interaction protein kinase C beta-b (Prkcbb) regulates its activity. Using PRKCB2 bait, identified functional ortholog humans from...
Abstract Background In recent years, several lines of evidence have shown an increase in Parkinson's disease prevalence rural environments where pesticides are heavily used. Although, the underlying mechanism for neuronal degeneration sporadic PD remains unknown, mitochondrial dysfunction, oxidative stress and proteasomal dysfunction proposed as contributing factors. this study rats were chronically continuously exposed to pesticide, dichlorvos identify molecular nigrostaital degeneration....
Multiple lines of evidence link the incidence diabetes to development Alzheimer's disease (AD). Patients with have a 50 75% increased risk developing AD. Cyclin dependent kinase 5 (Cdk5) is serine/threonine protein kinase,
The objective of this study was to elucidate an association between Apo- Eε4 allele and CSF biomarkers Aβ42 tau for the diagnosis Alzheimer's Disease (AD) patients. protein concentrations in were measured by using ELISA assays. levels found be decreased where as increased AD Moreover patients Apo-Eε4 carriers have shown low (328.86 ± 99.0 pg/ml) compared non-carriers (367.52 5 7.37 pg/ml), while higher (511 44.67 (503.75 41.08 pg/ml). Combination resulted sensitivity 75.38% specificity...
Parkinson’s disease (PD) is a chronic neurodegenerative disorder characterized by the loss of dopamine neurons in substantia nigra, decreased striatal levels, and consequent extrapyramidal motor dysfunction. Recent evidence indicates that cyclin-dependent kinase 5 (Cdk5) inappropriately activated several conditions, including PD. To date, strategies to specifically inhibit Cdk5 hyperactivity have not been successful without affecting normal activity. Previously we reported TFP5 peptide has...
It has been reported that cyclin-dependent kinase 5 (cdk5), a critical neuronal kinase, is hyperactivated in Alzheimer’s disease (AD) and may be, part, responsible for the hallmark pathology of amyloid plaques neurofibrillary tangles (NFTs). proposed by several laboratories hyperactive cdk5 results from overexpression p25 (a truncated fragment p35, normal regulator), which, when complexed to cdk5, induces hyperactivity, hyperphosphorylated tau/NFTs, amyloid-β plaques, death. previously shown...
Wilson disease (WD) is one of the most prevalent genetic diseases with an estimated global carrier frequency 1 in 90 and a prevalence 30,000. The owes its genesis to Kinnier who described disease, caused by accumulation Copper (Cu) various organs including liver, central nervous system, cornea, kidney, joints cardiac muscle which contribute characteristic clinical features WD. A number studies have reported variants ATP7B gene from diverse ethnic geographical origins. recent advent...
Background Advances in Next Generation Sequencing have made rapid variant discovery and detection widely accessible. To facilitate a better understanding of the nature these variants, American College Medical Genetics Genomics Association Molecular Pathologists (ACMG-AMP) issued set guidelines for classification. However, given vast number variants associated with any disorder, it is impossible to manually apply all known variants. Machine learning methodologies offer way classify large...
Abstract Background Genomic variations associated with dystonia in Asian Indians remain largely unknown. Objectives To identify genomic alterations the Indian population using next generation sequencing approaches. Methods From September 2018 to December 2023, we enrolled 745 individuals including probands and family members, Movement Disorder Registry Biobank. Clinical demographic data were captured on a REDCap platform. We performed whole exome (WES) DNA specimens obtained from 267...
Type 2 diabetes (T2D) is a metabolic disorder commonly linked with cognitive decline, increasing patients' susceptibility to dementia. Alzheimer's disease (AD) has strong connection hyperglycemia and insulin dysregulation. Interestingly, certain anti-diabetic drugs have shown potential in reducing T2D-induced impairment. Previous studies, including ours, highlighted the dysregulation of cyclin-dependent kinase 5 (Cdk5) activity both T2D AD, which may contribute pathological changes these...
Abstract Background One of the pathological hallmarks Alzheimer's disease (AD) is deposition ~4 kDa amyloid β protein (Aβ) within lesions known as senile plaques. Aβ also deposited in walls cerebral blood vessels many cases AD. A substantial proportion that accumulates AD brain Amyloid, which highly insoluble, proteinaceous material with a β-pleated-sheet conformation and extracellularly form 5-10 nm wide straight fibrils. As γ-secretase catalyzes final cleavage releases Aβ42 or 40 from...
Abstract Cyclin-dependent kinase 5 (Cdk5) is a key neuronal that upregulated during inflammation, and can subsequently modulate sensitivity to nociceptive stimuli. We conducted an in silico screen for Cdk5 phosphorylation sites within proteins whose expression was enriched nociceptors identified the chemo-responsive ion channel Transient Receptor Potential Ankyrin 1 (TRPA1) as possible substrate. Immunoprecipitated full length TRPA1 shown be phosphorylated by this interaction blocked TFP5,...