A5047110909- Gambling Behavior and Treatments
- Blood Pressure and Hypertension Studies
- Ovarian function and disorders
- Sperm and Testicular Function
- Personality Disorders and Psychopathology
- Assisted Reproductive Technology and Twin Pregnancy
- Dialysis and Renal Disease Management
- Prenatal Screening and Diagnostics
- Thyroid Disorders and Treatments
- Impact of Technology on Adolescents
- Pituitary Gland Disorders and Treatments
- Pharmacological Effects and Toxicity Studies
- Workaholism, burnout, and well-being
- Pharmacogenetics and Drug Metabolism
- Fetal and Pediatric Neurological Disorders
- Eating Disorders and Behaviors
- Chronic Kidney Disease and Diabetes
- Coenzyme Q10 studies and effects
- Prenatal Substance Exposure Effects
- Eicosanoids and Hypertension Pharmacology
- Ectopic Pregnancy Diagnosis and Management
- Therapeutic Uses of Natural Elements
- Cardiovascular Health and Risk Factors
- Hernia repair and management
- Pharmacological Receptor Mechanisms and Effects
IRCCS Policlinico San Donato
2024
University of Campania "Luigi Vanvitelli"
2007-2024
Farmaceutici Damor (Italy)
2024
Dompé (Italy)
2024
Hôpital Foch
2021-2023
Hôpital Antoine-Béclère
2017-2020
Assistance Publique – Hôpitaux de Paris
2017-2020
Université Paris-Sud
2017-2019
Université Libre de Bruxelles
2019
Virbac (France)
2019
Multiple modifiable risk factors for late complications in patients with diabetic kidney disease (DKD), including hyperglycemia, hypertension and dyslipidemia, increase the of a poor outcome. DKD is associated very high cardiovascular risk, which requires simultaneous treatment these by implementing an intensified multifactorial approach. However, efficacy intervention on major fatal/non-fatal events (MACEs) has been poorly investigated.
In a previous paper it was demonstrated that Coenzyme Q10, lipidic molecule with important antioxidant properties, is present at remarkable levels in human seminal fluid, and shows direct correlation parameters (sperm count motility). patients varicocele, on the contrary, sperm motility lacking higher proportion of Q10 found plasma. study, cell pellet spermatozoa, obtained after centrifugation semen, were evaluated. nonvaricocele subjects observed concentration (expressed as ng per million...
To evaluate in twin pregnancy the utility of non-invasive prenatal testing using circulating cell-free fetal DNA (cfDNA) screening for three main autosomal trisomies.cfDNA was offered to 492 patients with a without ultrasound anomaly as first-line test or after routine serum screening. Data were collected prospectively and retrospective analysis performed. cfDNA performed by massively parallel sequencing. The fetal-fraction threshold used evaluation 8%. Regression investigate effect on...
Background. The role of white coat hypertension (WCH) in the poor control blood pressure (BP) chronic kidney disease (CKD) is ill defined. Methods. We measured systolic clinical (CBP) and ambulatory (ABP) 290 consecutive patients with non-dialysis CKD [glomerular filtration rate (GFR) <60 ml/min/1.73 m2]. defined normotension (NOR) if CBP daytime ABP <130 mmHg, sustained (SH) when both BP ≥130 WCH only masked (MH) mmHg. Results. NOR were 15.5%, 31.7%, SH 46.9% MH 5.9%. Due to high prevalence...
Women with type 2 diabetes experience higher cardiovascular and mortality risk than men possibly because of a sub-optimal cardio-protective treatment. We evaluated whether an intensive multifactorial therapy (MT) produces similar protective effect on development adverse outcomes in women men. Nephropathy Diabetes study is open-label cluster randomized trial comparing the Usual Care (UC) or MT main factors (blood pressure < 130/80 mmHg, HbA1c 7%, LDL 100 mg/dL, total cholesterol 175 mg/dL)...
Coenzyme Q10 in seminal fluid shows a direct correlation with parameters except patients varicocele. To evaluate whether surgical treatment of varicocele could revert CoQ10 abnormalities, we have studied distribution thirty-three VAR patients, before and 6-8 months after varicocelectomy, twenty idiopathic oligozoospermia, eleven isolated asthenozoospermia sixteen normal fertile men. was assayed total fluid, plasma or cell pellet by HPLC. A significantly higher proportion vs. controls (mean...
Introduction Diabetic retinopathy (DR) is a microvascular complication of diabetes in which neurodegeneration has been recently identified as driving force. In the last years, mesenchymal stromal cells (MSCs) and neurotrophins like Nerve Growth Factor (NGF), have garnered significant attention innovative therapeutic approaches targeting DR-associated neurodegeneration. However, delivering neurotrophic factors directly eye remains challenge. Hence, this study evaluated effects MSCs from human...
Objectives: The goal of this study was to assess the effect unilateral salpingectomy on number mature follicles in ipsilateral ovary during an assisted reproductive technology (ART) stimulation cycle, as compared contralateral ovary. Methods: This a retrospective, single-center, case-control cohort conducted from 2017 2022. Patients 18 43 years old who underwent at least one ART cycle before and after were included. recruited follicles, including (≥16 mm) intermediate (13-15.5 mm), side...
Pathological gambling (PG) disorder occurs when a person gambles repetitively despite severe negative effects on important aspects of life. PG tends to be heterogonous in which patients differ with respect type and intensity behavior, psychiatric comorbidity, family history, age at onset gender. Gamblers may accordingly classified into three subtypes: the "impulsive", "obsessive-compulsive" "addicted" subtypes. characterize sample Italian pathological gamblers assess prevalence various...
There is substantial evidence indicating that pharmacological treatments targeting glutamatergic transmission are of potential utility in the treatment drug addiction. The aim this study was to evaluate long-term outcome patients with pathological gambling. Fifteen fulfilling criteria for gambling and receiving drugs effects on (amantadine, N-acetylcysteine, gabapentin, pregabalin topiramate) were enrolled. Gambling craving (Gambling Symptom Assessment Scale, G-SAS, visual analogue scale,...
Abstract Background In Italy, cardiovascular disease (CVD) remains the leading cause of death among women. Raising awareness women about their main health threats still an unmet goal. Purpose To assess determinants, including sociodemographic and clinical variables lifestyle patterns, in Lombardy region (Italy) relationships to CVD awareness. Methods Women (≥18 years age) living were invited from September 2022 November 2023 complete a web survey created with SurveyMonkey® software. The...
Abstract Background Despite strides in prevention, diagnosis, and treatment of cardiovascular disease (CVD), CVD remains the leading cause death (LCOD) women. While global initiatives aim to enhance awareness, recent studies reveal deficiencies, particularly Europe where misconceptions prevail, hindering women’s understanding severity. Purpose To describe determinants affecting awareness as LCOD among women Lombardy region, Italy. Methods A web-based survey (the ‘Call for Women’ Project) was...
Thyrotropin releasing hormone (TRH) administration is known to induce a greater TSH response in normal subjects than obese subjects. In obesity even GH and PRL various stimuli are blunted, presumably because of an augmented somatostatinergic tone Further studies have shown that pyridostigmine (Pyr), acetylcholinesterase inhibitor, capable augmenting by means somatostatin inhibition. order evaluate the possible interference increased on secretion, we studied TRH bolus 5 children with or...
Frequent and increasing relations among psychiatric substance dependence disorders, have made, to date, more complex the treatment of this dependence, especially when patient is facing difficult task maintaining abstinence, which requires a work self-awareness, motivation change active modification dysfunctional lifestyles. Our study has aim detect patients' changes in personality between beginning rehabilitative therapy its end, trying get information on aspects addiction affects most....
Introduction and Aims: Hemoglobin (Hb) stability with C.E.R.A. once-monthly (QM) was evaluated in high risk patients chronic kidney disease (CKD) on dialysis switched from shorter-acting erythropoiesis-stimulating agents (ESAs).Methods: Adult CKD were converted to QM achieve a target Hb of 10.0-12.0g/dL (5 studies), 10.5-12.5 g/dL (3 11.0-12.5 11-13 (one study each).High (HR) low (LR) subgroups defined the basis therapy parameters before switching: epoetin or darbepoetin alfa dose (=8000 IU...
Previous studies have indicated different abnormalities of PRL secretion in patients with primary empty sella (PES). Since it is known that endogenous opiates and dopamine interact modulating secretion, we studied the effect an opiate receptor blockade (with Naloxone, NAL, 1.6 mg/h as a continuous infusion) on anterior pituitary hormones responsiveness to metoclopramide (MCP), 10 premenopausal normoprolactinemic PES, follicular phase, order investigate neurotransmitter present such syndrome....